Protein Alignment CG6071 and lta4h

DIOPT Version :9

• Sequence 1: NP_648488.1
• Gene: CG6071 / 39308
• FlyBaseID: FBgn0036186
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_998451.1
• Gene: lta4h / 406575
• ZFINID: ZDB-GENE-040426-2477
• Length: 611
• Species: Danio rerio
• Alignment Length: 616
• Identity: 127/616 - (20%)
• Similarity: 228/616 - (37%)
• Gaps: 149/616 - (24%)

  Fly    40 EQNQFEGIVSIDIEATQPT-RVIYLNSLNITISRQRTWIYRWASGR----KIGALQIKRIIKKTS 99
            :::..:|.|::.:|..:.. ..:.|:|.::.||:..      |:|:    ::||   |...|.:.
Zfish    30 DRHVLKGKVALTVEVLEDKFSSLTLDSKDLKISKVS------ANGQAAKFELGA---KHKFKGSP 85

  Fly   100 LIKIVIELPLRSGEIYTLNMLFSGN--------LDRSQQYGYFAGYYDKTPRVFYSATRLEPDYA 156
            | :|.:...|..|:...:.:.:..:        |...|..|      .|.|.:|   ::.:..:.
Zfish    86 L-EITLPFELSRGQHVIVEIEYETSPTATALQWLTPKQTAG------KKHPYLF---SQCQATHC 140

  Fly   157 HTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQVMWT 221
            .|:.||.|.|..:..|...:...|:.|||.:.....::|.....:.|...|....|:.:..:...
Zfish   141 RTMVPCQDTPSVKHTYYAQVSVPRELVALMSALRDGQEPDPSDSSRVIYRFRQPVPMPSYLIAIV 205

  Fly   222 LHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLF--AYPLPKGADWGGKVD 284
            :..||....||.:     .|||.....::.|..       |::.||:.  |..|.....| |:.|
Zfish   206 VGALESREIGPRS-----RVWSEKEYVDEAAYE-------FAETETMLKTAESLAGPYVW-GQYD 257

  Fly   285 HVVLPRYTEMYSG--QGIMVYGEDIVDSGQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRN 347
            .:|||. :..|.|  ...:.:....|.:|.   .||...:|..::..|.|.||.....:..::..
Zfish   258 VLVLPP-SFPYGGMENPCLTFVTPTVLAGD---RSLAGVIAHEISHSWTGNLVTNRTWEHFWLNE 318

  Fly   348 GINYYLSVQV-MAMDKE---------AYNTTHLS---------KTRLDVLYHDSLAKVKSIATDV 393
            |...|:...: ..|:.|         .:...|.|         .|.|....|:         .|.
Zfish   319 GHTVYIERMIARCMEGEQLRQFKGIGGWKELHESVKQFGANNVLTNLVPNLHE---------VDT 374

  Fly   394 KESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLP 458
            .|:......:|...||.|:.::..|.::|:..::.:.:.:|..|.:::| |:.:
Zfish   375 DEAFSSVPYEKGFALLYHLEELMGGPEVFMGFVKSYIQLFAYGSVTTEE-WKNY----------- 427

  Fly   459 TGVSLPTVME------------SWMKQPGFPLLTVQRDD--AKQIVTITQSRYYQKYLDNSS--- 506
                |.|..:            :||..||...:..|.|.  |....::.|.....|..|.:|
Zfish   428 ----LFTYFKDKVDILNKVDWNAWMHTPGMAPVRPQYDTTMADACTSLCQKWVKAKEADLASFTE 488

  Fly   507 NDCWWVPVAYIVRNLTLPQ-VEW-----------LGCQKNSRDILELSHIANPE---DWLLINVD 556
            .|         |:.|..|| :|:           |...|...::.:|::|.|.|   .||.|.|.
Zfish   489 AD---------VKQLNSPQLIEFMALLLQEDPLPLSHVKKMGEVYKLNNIKNAEVRFRWLRICVK 544

  Fly   557 A----AVPLRVFYDSYNLQLISEALRQDFTQ 583
            |    ||||.       |::.:|..|..||:
Zfish   545 AQWEEAVPLA-------LKMATEQGRMKFTR 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	94/484 (19%)
		ERAP1_C	551..929	CDD:288671	13/37 (35%)
lta4h	NP_998451.1	leuko_A4_hydro	18..607	CDD:274120	127/616 (21%)
		M1_LTA4H	18..449	CDD:189006	91/479 (19%)
		Leuk-A4-hydro_C	467..606	CDD:286244	30/118 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900