DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6071 and LTA4H

DIOPT Version :9

Sequence 1:NP_648488.1 Gene:CG6071 / 39308 FlyBaseID:FBgn0036186 Length:962 Species:Drosophila melanogaster
Sequence 2:NP_000886.1 Gene:LTA4H / 4048 HGNCID:6710 Length:611 Species:Homo sapiens


Alignment Length:607 Identity:112/607 - (18%)
Similarity:223/607 - (36%) Gaps:143/607 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 GIVSIDIEATQPT-RVIYLNSLNITISRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELPL 109
            |..::.:::.:.. |.:.|::.::||.:.      ..:|:::.....:|...|.|.::|.:.:.|
Human    37 GTAALTVQSQEDNLRSLVLDTKDLTIEKV------VINGQEVKYALGERQSYKGSPMEISLPIAL 95

  Fly   110 RSGEIYTLNMLFSGN--------LDRSQQYGYFAGYYDKTPRVFYSATRLEPDYAHTVFPCFDDP 166
            ...:...:.:.|..:        |...|..|      .:.|.:|   ::.:..:...:.||.|.|
Human    96 SKNQEIVIEISFETSPKSSALQWLTPEQTSG------KEHPYLF---SQCQAIHCRAILPCQDTP 151

  Fly   167 RFRTPYNITLVHDRKYVALSNM-----PPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQLE 226
            ..:..|...:...::.|||.:.     .|..|.|.::|..::...     |:....:...:..||
Human   152 SVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKV-----PIPCYLIALVVGALE 211

  Fly   227 KVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGAD--WGGKVDHVVLP 289
            ....||     ...|||.....||.|..       ||:.|::.......|..  | |:.|.:|||
Human   212 SRQIGP-----RTLVWSEKEQVEKSAYE-------FSETESMLKIAEDLGGPYVW-GQYDLLVLP 263

  Fly   290 RYTEMYSGQGIMVYGED-----IVDSGQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGI 349
            . :..|.|.      |:     :..:...|.:||...:|..::..|.|.||..:..|..::..|.
Human   264 P-SFPYGGM------ENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGH 321

  Fly   350 NYYLSVQV--------------------MAMDKEAYNTTH-LSKTRLDVLYHDSLAKVKSIATDV 393
            ..||...:                    :....:.:..|| .:|..:|:...|......|:..: 
Human   322 TVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYE- 385

  Fly   394 KESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLP 458
                      |...||.::.::..|.::||..|:.:.::::..|.::.: |::|.....:.   .
Human   386 ----------KGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDD-WKDFLYSYFKD---K 436

  Fly   459 TGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQS--RYYQKYLD------NSSNDCWWVPVA 515
            ..|.......:|:..||.|.:....|     :|:|.:  ...|:::.      ||.|       |
Human   437 VDVLNQVDWNAWLYSPGLPPIKPNYD-----MTLTNACIALSQRWITAKEDDLNSFN-------A 489

  Fly   516 YIVRNLTLPQVEWLGCQKNSRDILELSHIANPED---------------WLLINVDA----AVPL 561
            ..:::|:..|:.....|...|..|.|.||...::               ||.:.:.:    |:||
Human   490 TDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPL 554

  Fly   562 RVFYDSYNLQLISEALRQDFTQ 583
            .       |::.:|..|..||:
Human   555 A-------LKMATEQGRMKFTR 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6071NP_648488.1 GluZincin 25..477 CDD:301352 85/472 (18%)
ERAP1_C 551..929 CDD:288671 9/37 (24%)
LTA4HNP_000886.1 leuko_A4_hydro 6..608 CDD:274120 112/607 (18%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 135..137 0/1 (0%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 267..272 2/10 (20%)
Inhibitor ARM1 binding. /evidence=ECO:0000269|PubMed:24591641 362..365 0/2 (0%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 564..566 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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