DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6071 and LNPEP

DIOPT Version :9

Sequence 1:NP_648488.1 Gene:CG6071 / 39308 FlyBaseID:FBgn0036186 Length:962 Species:Drosophila melanogaster
Sequence 2:NP_005566.2 Gene:LNPEP / 4012 HGNCID:6656 Length:1025 Species:Homo sapiens


Alignment Length:926 Identity:199/926 - (21%)
Similarity:382/926 - (41%) Gaps:162/926 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            |.||||.|::...|.|    ..|.|.|:|.::|.|.|..|.|:|....|||. |::...:|..|.
Human   172 VVPLRYELSLHPNLTS----MTFRGSVTISVQALQVTWNIILHSTGHNISRV-TFMSAVSSQEKQ 231

  Fly    87 GALQIKRIIKKTSLIKIVIELP--LRSGEIYTLNMLFSGNLDRSQQYGYFAGYY--DKTPRVFYS 147
            .     .|::.....:|.|..|  |.:|..|||.:.:|.|:. |..||::...|  :...:.:::
Human   232 A-----EILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANIS-SSYYGFYGFSYTDESNEKKYFA 290

  Fly   148 ATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPP 212
            ||:.||..|.:.|||||:|.|:..:.|.::.|.:|.||||||  ::......:..|...|..|..
Human   291 ATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMP--KKSSVVLDDGLVQDEFSESVK 353

  Fly   213 LATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVP---EMTPNLFSKYETLF--AYP 272
            ::|..|.:.:.:::.:  .....|..:::::.|   ||:.:|.   |.|..|...::..|  .||
Human   354 MSTYLVAFIVGEMKNL--SQDVNGTLVSIYAVP---EKIGQVHYALETTVKLLEFFQNYFEIQYP 413

  Fly   273 LPKGADWGGKVDHVVLPRY-TEMYSGQGIMVYGED--IVDSGQNGL---ESLQETLAELVARQWN 331
            |.       |:|.|.:|.: .......|::.:.|:  :.||..:.:   :.:.:.:|..:|.||.
Human   414 LK-------KLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWF 471

  Fly   332 GLLVNLEDSDEEYVRNG---INYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDV 393
            |.||.::..::.::..|   ...|.|::.:..:..:|.  .....|...:..|||.....|::.|
Human   472 GNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYE--DFLDARFKTMKKDSLNSSHPISSSV 534

  Fly   394 KESGH-----QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARR 453
            :.|..     ..|...|...|:.|||..|.:.:|...:..:...::.:|..|.:||:.|.....:
Human   535 QSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQ 599

  Fly   454 SHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYY----QKYLDNSSNDCWWVPV 514
            :      :.:..:|::|..|.||||:|||: ..|::. |.|.|::    .:...:.::..|.:|:
Human   600 T------LDVKRMMKTWTLQKGFPLVTVQK-KGKELF-IQQERFFLNMKPEIQPSDTSYLWHIPL 656

  Fly   515 AYIVRNLTLPQVEWLGCQKNSRDILELSHIANPED--WLLINVDAAVPLRVFYDSYNLQLISEAL 577
            :|:.......:.:.:........::.|:     |:  |:.:|::......|.|...:.:.:...|
Human   657 SYVTEGRNYSKYQSVSLLDKKSGVINLT-----EEVLWVKVNINMNGYYIVHYADDDWEALIHQL 716

  Fly   578 RQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRM 642
            :.:...:.:..|..|:::...|:..|::|.....::|:||.||........||...:.:.:::. 
Human   717 KINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE- 780

  Fly   643 TTGFRIFKL-YM---QKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESP 703
                   || ||   .:|:...||...|.:..:                                
Human   781 -------KLGYMDLASRLVTRVFKLLQNQIQQQ-------------------------------- 806

  Fly   704 DTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQA 768
                                      |.:.:.|.|...|.:.|...||...:..|.|.|.:.|..
Human   807 --------------------------TWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDD 845

  Fly   769 AMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTE----YW 829
            .|....:.|:|.::...|...|.:.  :..|..:...:....::.|::.:|.:|:.:.:    ||
Human   846 WMASNGTQSLPTDVMTTVFKVGAKT--DKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYW 908

  Fly   830 AMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKE---------ILRSKDVKL 885
            .|:..|:.  |:.:..:      ||.::|:...::.|.....|..||         .|.|..::.
Human   909 LMKSSLNG--DNFRTQK------LSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQN 965

  Fly   886 ILTPFINAMSTKAEFS 901
            |:.......|||...|
Human   966 IVAGSTYLFSTKTHLS 981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6071NP_648488.1 GluZincin 25..477 CDD:301352 118/474 (25%)
ERAP1_C 551..929 CDD:288671 63/368 (17%)
LNPEPNP_005566.2 Dileucine internalization motif. /evidence=ECO:0000255 53..54
Dileucine internalization motif. /evidence=ECO:0000255 76..77
Tankyrase binding 96..101
M1_APN_2 175..617 CDD:189008 118/474 (25%)
Substrate binding. /evidence=ECO:0000250 428..432 0/3 (0%)
ERAP1_C 689..1009 CDD:314669 64/369 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155401
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

Return to query results.
Submit another query.