DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and erap1b

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_956500.2	Gene:	erap1b / 393175	ZFINID:	ZDB-GENE-040426-934	Length:	963	Species:	Danio rerio

Alignment Length:	1079	Identity:	242/1079 - (22%)
Similarity:	402/1079 - (37%)	Gaps:	274/1079 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLKILVLFCTLLSAKLAE--SF-------------------VKPLRYNLTILTRLGSEDEQNQF 44
            :||.::||...|.:|...|  ||                   :.||.|||.|...|.|.|    |
Zfish     9 VLLNLIVLPIHLWAAVTPEPTSFPISSSGEPFPWNKMRLPDTISPLHYNLLIHPNLTSLD----F 69

  Fly    45 EGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIGAL------QIKRIIKKTSLIKI 103
            .|.|.|.||..|.|:.|.|:|.|:.||..|......|..:.:..|      ||..:..|..
Zfish    70 TGSVQIQIEVLQDTKTIILHSKNLQISSARLLDANIAQQQPLKVLEYPYFQQIALVSDKAL---- 130

  Fly   104 VIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRV------FYSATRLEPDYAHTVFPC 162
                 |:.|.:|::.:.|:.||..|     |.|:|..|.|.      ..::|:.|...|...|||
Zfish   131 -----LKRGHVYSVELHFAANLSES-----FHGFYKSTYRTSKGDVRVVASTQFEATSARAAFPC 185

  Fly   163 FDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIEN-YVSTTFMGSPPLATQQVMWTLHQLE 226
            ||:|.|:..:::.:..:.|::||||||.:..   .|::| .....|..|..::|..|.:.:....
Zfish   186 FDEPAFKANFSVQIRREAKHIALSNMPKLRT---LELKNGLFEDQFDVSVKMSTYLVAYIVSDFL 247

  Fly   227 KVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLF--AYPLPKGADWGGK------- 282
            .: |..:..|..|:|::.|...::.....:....|...|:..|  .|||||......|
Zfish   248 SI-SKTSQHGVQISVYAVPEKIDQAEFALDAAVKLLDFYDDYFDIPYPLPKQEKPTIKHAKEEFS 311

  Fly   283 ------VDHVVLPRYTEMYSGQ----GIMVYGE-----DIVDSGQNGLESLQETLAELVARQWNG 332
                  ||...:|   :..||.    |:..|.|     |...|..:....:...:|..:|.||.|
Zfish   312 VYIICFVDLAAIP---DFQSGAMENWGLTTYRESALLFDPHKSSASDKLGITMIIAHELAHQWFG 373

  Fly   333 LLVNLEDSDEEYVRNGI-------------------NYYLSVQVMAMDKEAYNTTHLSKTRLDVL 378
            .||.::..::.::..|.                   :|:|.....||:.::.:::|...|.:
Zfish   374 NLVTMQWWNDLWLNEGFAKFMEFVSVNITNPELQVEDYFLGKCFEAMEVDSLSSSHPVSTPV--- 435

  Fly   379 YHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKEL 443
              ::.|:::.:..||...       |..|:| :||:..|..|:|..|:.::.|.|:..:..:..|
Zfish   436 --ENPAQIQEMFDDVSYD-------KGACIL-NMLREFLTPKIFKLGIVKYLKHYSYQNTVNSNL 490

  Fly   444 WEEF-------------------------QRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQR 483
            ||..                         ..||.:.|. ...:.:..:||:|..|.||||:|:..
Zfish   491 WESLTNVCDSDGLDEGRLKGDESCRHSASNTGASKWHS-EDELDVKAMMETWTLQEGFPLITIAV 554

  Fly   484 DDAKQIVTITQSRYYQK-YLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANP 547
            ...:  |.::|.||.:. .|..:|:..|.||:.||..:.|......|   |...|:|.|     |
Zfish   555 KGRE--VRLSQERYLKSDDLSQTSSFLWQVPLTYITSDSTTVHRFLL---KTKTDVLYL-----P 609

  Fly   548 E--DWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVT 610
            |  ||:..|||.:....|.|:......:...|:.:.|.:....|..|:::|..|...|:||.:..
Zfish   610 EEVDWIKFNVDMSGYYIVHYEGSGWDDLITLLKHNHTALSSNDRASLINNAFQLVSVGKLPLDKA 674

  Fly   611 LNVISYLSNETSVLVWETALLNLEKLQSIM---------RMTTGFRIFKLYMQKLIEPAFKTTLN 666
            |::..|||.||.::........|..|..:|         ....|: |.:|: |||||....|...
Zfish   675 LDLTLYLSKETEIMPVTQGFNELVPLYKLMEKRDMVELENQMKGY-ILQLF-QKLIEQQLWTDEG 737

  Fly   667 SLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTE 731
            |:|.:
Zfish   738 SVSER------------------------------------------------------------ 742

  Fly   732 SPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLE 796
                     .|.:.|....|......|:::|.|.|....|...:.|:|.::...|...|.|.  |
Zfish   743 ---------MLRSYLLLFGCVRGHPPCVSNATQLFNLWRDSDGNMSLPNDVTMAVFSVGART--E 796

  Fly   797 VHWIMVRDMFFESENDK---------ERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASL 852
            ..|    |..||...:.         :::::.:.|....::...|.|....:.::.:|..:|
Zfish   797 DGW----DFLFEKYKESMYVSMKSRIKQALMTSPLDHKLKWMMEQSLEGELIKTQDLPYVVT--- 854

  Fly   853 LSAVLRSPLGYYVGKQFLIDHSKEILR-----SKDVKLILTPFINAMSTK---AE----FSALND 905
              :|.|:|..|.....||..:...:::     |..:..::....|..||:   ||    ||.|..
Zfish   855 --SVSRNPKAYKHAWDFLQANWDSLIKKFDLGSHSIAHMVVGVTNQYSTREMLAEVRNFFSLLQP 917

  Fly   906 HLHRNLPSSMVSGLSSTLESGLDRVNWRN-NLYFDLLKA 943
            .....|..     :...:|:..:.:.|.: ||  .||||
Zfish   918 ETGAELRC-----IQQAVENIEENIRWMDKNL--PLLKA 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	126/532 (24%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	74/407 (18%)
erap1b	NP_956500.2	Peptidase_M1	46..453	CDD:279741	105/443 (24%)
		M1_APN_2	54..548	CDD:189008	126/532 (24%)
		ERAP1_C	615..932	CDD:288671	73/403 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850