DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Psa

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster

Alignment Length:	958	Identity:	197/958 - (20%)
Similarity:	388/958 - (40%)	Gaps:	176/958 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            |.|..|.|.:...|    ::..|.|...:.:...:||..|.||:|:|.:.......       :.
  Fly   223 VVPRHYELLLQPNL----KEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHF-------EC 276

  Fly    87 GALQIKRII----KKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKT-PRVFY 146
            ..|:.::|:    .:|:.::...|:|..:..:  |:|.|:|.|:...:..|.:.|:... ...|.
  Fly   277 SKLKPEKIVYSAENETATLEFAQEIPAETQGV--LHMSFTGELNDKMKGFYRSKYFGPNGEERFA 339

  Fly   147 SATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSP 211
            ..|:.|...|...|||:|:|..:..::||||..:..|||||||.::|....  :......|..:|
  Fly   340 GVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLP--DGLRRVRFDRTP 402

  Fly   212 PLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLF--AYPLP 274
            .::|..|...:.:.:.| .|.:..|..:.|::.....|:.....|:...:...|:..|  |||||
  Fly   403 IMSTYLVAVVVGEYDYV-EGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLP 466

  Fly   275 KGADWGGKVDHVVLPRYTE-MYSGQGIMVYGED--IVDSGQNGL---ESLQETLAELVARQWNGL 333
                   |:|.:.:..::. .....|::.|.|.  :||.....|   :|:..|:...:|.||.|.
  Fly   467 -------KMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGN 524

  Fly   334 LVNLEDSDEEYVRNGINY-----YLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDV 393
            ||.:|.....::..|  |     :|.|..:..:.:.: |..::......|..|||.....|...|
  Fly   525 LVTMEWWTHLWLNEG--YASFVEFLCVHHLFPEYDIW-TQFVTDMYTRALELDSLKNSHPIEVPV 586

  Fly   394 KESGH--------QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRG 450
               ||        .::...|...:|.||...:|:..|.||:..:..|:...:..:::||...|..
  Fly   587 ---GHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEA 648

  Fly   451 ARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDA---KQIVTITQSRYYQKYLDNSSNDCWWV 512
            :.:        ::..||.||.:..|||:::|:.:..   ::::.:.|.::.........|..|.|
  Fly   649 SSK--------NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVV 705

  Fly   513 PVAY--------IVRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYN 569
            |::.        |.:...|        .|:|.:: .|.:: :.:||:.||.......|..|....
  Fly   706 PISVSTSKNPTGIAKTFLL--------DKSSMEV-TLDNV-DEDDWIKINPGTVGYYRTRYSQEM 760

  Fly   570 LQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLN-L 633
            |:.:..|:.:  .::|.|.|:.|:||..::..:|.......|.::....|||:..|| ||:.| |
  Fly   761 LEQLMPAVEK--MELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVW-TAITNSL 822

  Fly   634 EKLQSIMRMTTGFRIFKLYMQKLIEP-AFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESP 697
            ..|..::..|.....|..:.:.|.|| |::     |..:.|.|.
  Fly   823 TNLHILISHTDLMEDFHRFGRNLYEPVAYR-----LGWEPRDGE--------------------- 861

  Fly   698 DTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDA 762
                                       ...||          |..|.:|.||. .|...:.:.:|
  Fly   862 ---------------------------NHLDT----------LLRSLVLTRLV-SFRSSDTIEEA 888

  Fly   763 QQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTE 827
            :.||:..::  .:..:|.::|.......:::|.|..:..:.|::..::..:|:..:..:|.|..:
  Fly   889 KIRFRRHVN--GTELLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGD 951

  Fly   828 YWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILR--------SKDVK 884
            ...:::::.:|: |.:|....:..::.||..:|.|..:..:|..:::|::|.        |:.:|
  Fly   952 LKLLRRVIDFAM-SSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQGGFLLSRLIK 1015

  Fly   885 LILTPFINAMSTK--AEFSALNDHLHRNLPSSMVSGLSSTLESGLDRV 930
            .::..|.:....|  .||..:|          .:.|...|:...::.:
  Fly  1016 YLIENFASEERAKEVEEFLQVN----------QIPGCERTVSQAVETI 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	109/477 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	71/389 (18%)
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	94/409 (23%)
		M1_APN_2	227..667	CDD:189008	109/476 (23%)
		ERAP1_C	742..1052	CDD:288671	71/389 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462110
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850