DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG3502

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	977	Identity:	259/977 - (26%)
Similarity:	448/977 - (45%)	Gaps:	156/977 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGR-K 85
            |:||.|||.|||.|.|.|:  :|||.|:||:.|.:.|:.|.|::..:.|...||.:   .||: |
  Fly    34 VEPLHYNLRILTHLNSTDQ--RFEGSVTIDLLARETTKNITLHAAYLKIDENRTSV---VSGQEK 93

  Fly    86 IGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYD-KTPRVFYSA- 148
            .|..:|: :.:..:...:.:...|...:||.|.|.|...|:.||...|.:.|.| .|..|.:.|
  Fly    94 FGVNRIE-VNEVHNFYILHLGRELVKDQIYKLEMHFKAGLNDSQSGYYKSNYTDIVTKEVHHLAV 157

  Fly   149 TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYV---STTFMGS 210
            |:..|.:|...|||||:|.::..:||||.:.:||:.||.||.:..:.:..:.|||   ..|.:.:
  Fly   158 TQFSPTFARQAFPCFDEPSWKATFNITLGYHKKYMGLSGMPVLRCQDHDSLTNYVWCDHDTLLRT 222

  Fly   211 PPLATQQVMWTLHQLEKVYSGPAAAGENITV-------WSRPHLAEKLAKVPEMTPNLFSKYETL 268
               :|..|.:.:|.||.     ||..|:.|.       |.:|.|..:.....|:.|.|.|.||.|
  Fly   223 ---STYLVAFAVHDLEN-----AATEESKTSNRVIFRNWMQPKLLGQEMISMEIAPKLLSFYENL 279

  Fly   269 FA--YPLPKGADWGGKVDHVVLP--RYTEMYSGQGIMVYGEDIVDSGQNGLESLQE-----TLAE 324
            |.  :||       .|||.:.:|  |:|.| ...|::.|.|:.:...|......|:     |:|.
  Fly   280 FQINFPL-------AKVDQLTVPTHRFTAM-ENWGLVTYNEERLPQNQGDYPQKQKDSTAFTVAH 336

  Fly   325 LVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDK--------EAYNTTHLSKTRLDVLYHD 381
            ..|.||.|.||.:...::.:::.|.:.|..  .:|:|.        |.:    :|:...:....|
  Fly   337 EYAHQWFGNLVTMNWWNDLWLKEGPSTYFG--YLALDSLQPEWRRGERF----ISRDLANFFSKD 395

  Fly   382 SLAKVKSIATDVKESGH-----QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSK 441
            |.|.|.:|:.|||....     .:...:|..|.|.||...:|::.|..|::.|.:|::..:.:..
  Fly   396 SNATVPAISKDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFSFGNVAQA 460

  Fly   442 ELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSS 506
            :||...|..|.::..:.:..:|...|:||..|.|:||:|:.|:.....||:.|||::|::....:
  Fly   461 DLWNSLQMAALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGEVTLNQSRFFQEHGIEKA 525

  Fly   507 NDCWWVPVAYIVRNL-----TLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYD 566
            :.|||||:.::.:||     |.||. ||.|..|:: :|:|....:.::|:::|...|...||.||
  Fly   526 SSCWWVPLRFVRQNLPDFNQTTPQF-WLECPLNTK-VLKLPDHLSTDEWVILNPQVATIFRVNYD 588

  Fly   567 SYNLQLISEALRQDFTQ--IPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETA 629
            .:|.:||.|:||.|...  |.:|::.||:||.::|:......|:...:::.||..|...|.|:.|
  Fly   589 EHNWRLIIESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFDLLEYLKKEQDFLPWQRA 653

  Fly   630 LLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTT 694
            :..|.:|.:::.:....: ||.|||||:                    :|:..:.|   :.||..
  Fly   654 IGILNRLGALLNVAEANK-FKNYMQKLL--------------------LPLYNRFP---KLSGIR 694

  Fly   695 ESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECL 759
            |:....:                                     |:..:...|..||::.:.:|
  Fly   695 EAKPAIK-------------------------------------DIPFAHFAYSQACRYHVADC- 721

  Fly   760 TDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSC 824
            ||..:........:....:|.:.:::..|..:..|.:..::.|..:|..|.|..:|.||.::|.|
  Fly   722 TDQAKILAITHRTEGQLELPSDFQKVAYCSLLDEGGDAEFLEVFGLFQNSTNGSQRRILASALGC 786

  Fly   825 TTEYWAMQKLLSWAL--DSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEI---LRSKDVK 884
            ...:...::.|::.|  |.|.:......::.||:.|.|| ......::|.|:|::   .:.|::.
  Fly   787 VRNFGNFEQFLNYTLESDEKLLGDCYMLAVKSALNREPL-VSPTANYIISHAKKLGEKFKKKELT 850

  Fly   885 -LILTPFINAMST------KAEFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLLK 942
             |:|:...|..||      ||:...|.:         ....|...|..|.....|:.:...|.::
  Fly   851 GLLLSLAQNLRSTEEIDRLKAQLEDLKE---------FEEPLKKALYQGKMNQKWQKDCSSDFIE 906

  Fly   943 AI 944
            ||
  Fly   907 AI 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	142/486 (29%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	84/391 (21%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	124/418 (30%)
		M1_APN_2	37..496	CDD:189008	142/486 (29%)
		ERAP1_C	573..890	CDD:288671	83/388 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449989
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850