DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG40470

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	1011	Identity:	219/1011 - (21%)
Similarity:	402/1011 - (39%)	Gaps:	210/1011 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KILVLFCTLLSAKLAESFVK------------------PLRYNLTILTRLGSEDEQNQFEGIVSI 50
            :.|.:...||:|...|:||.                  ||.|.:.|...:   |.|| |||.:.:
  Fly    21 RTLFILTILLTAPGLEAFVNDFSSLHVISEVRLPKEVLPLSYEVLIEPHM---DNQN-FEGSIRM 81

  Fly    51 DIEATQPTRVIYL---NSLNITISRQRTWIYRWASG---RKIGALQIKRIIKKTSLIKIVIELPL 109
            .:.....::.:|.   ::|.|.:|:..........|   :.:..|:..|:.:|...: :.::..:
  Fly    82 HLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNMGDGTLDKNVIILRGVRLPRKPVFV-LYLKDKI 145

  Fly   110 RSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKT---PRVFYSATRLEPDYAHTVFPCFDDPRFRTP 171
            :.|....|::.|.||:..::: |.|..||..:   ....|.||.|:|:.|..:|||||:|..:.|
  Fly   146 KKGSECLLDIYFQGNISETEE-GLFRSYYTNSGNDGEEIYLATNLKPNNARRLFPCFDEPGIKVP 209

  Fly   172 YNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQV--------MWTLHQLEKV 228
            :|:::...:.|:.|.|.|......:.::.:|....|..:.|::|...        ||..|::.|.
  Fly   210 FNVSIARPKGYITLFNTPLHNTINHPKLRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIVKS 274

  Fly   229 YSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYTE 293
            ...||     |.:||....:..|..:........:..:..|..|||.     .|:|.:.:|....
  Fly   275 SDIPA-----INIWSNNLSSTNLLDIQNKLNVAHTTIQHFFNIPLPL-----TKLDVIAIPSLAT 329

  Fly   294 M--YSGQGIMVYGEDIVDSGQNGLESLQETLAEL---VARQWNGLLVNLEDSDEEYVRNG-INYY 352
            :  .|..||::..|.         |.|::.:.|:   :..||.|:.:..|...:..|... |::.
  Fly   330 LPFISASGILIARES---------EILKKDVFEISRELIYQWIGIWITPEWWTDANVNKALISFI 385

  Fly   353 LSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAK--VKSIATDVKESGHQKLRKKKMCLLIHMLKV 415
            .|..|..::...........|.|..||:: |:|  ..|..|.:|    .:....|:.|:|.||.:
  Fly   386 ASEIVFEINGGIEFNGKYPMTILYSLYYE-LSKRYPNSHITGIK----HEFASIKVQLIIRMLSL 445

  Fly   416 ALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLT 480
            .:|...|..|:|.|...|...:..|.:.|......|:..:.|.:.:|:.::.|||::....||:|
  Fly   446 TVGKYTFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVT 510

  Fly   481 VQRDDAKQIVTITQSRYYQKYL---DNSSNDCWWVPVAYIVRNLTLPQV-----EWLGCQKNSRD 537
            :.||...:...:.|..|.::.|   .:..|..||:|:| :.|..:|..|     :|:   ..:|.
  Fly   511 IIRDYDSETAIVQQKVYLRERLHDVPDQDNMLWWIPIA-LKRQDSLSFVNTGSFKWM---NKTRQ 571

  Fly   538 ILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQ--IPELSRIQLVDDALSLS 600
            :| :|::.:...::::|.:...|..|.||..|..::|:.||.:..:  ||..:|.:|:.||.:|:
  Fly   572 ML-ISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLA 635

  Fly   601 WSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTL 665
            ::|.|.::..|||..:|..|.:.:||......|:::...:..::..:.|:||:.:|:.|.:
  Fly   636 YAGELNFSTALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLY---- 696

  Fly   666 NSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTT 730
                                   |..||..               ..|..|.||....|.|
  Fly   697 -----------------------EYLGTAH---------------FNEDINITELRKLTTS---- 719

  Fly   731 ESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQ---KSSSSIPEEIREIVLCRGIR 792
                              ..|:.....|..:|::.|...::.   ...:.:|.|    .:|...:
  Fly   720 ------------------FLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNE----YICSIFK 762

  Fly   793 NGLEVHWIMVRDM---FFESENDKERSILLNSLS-CTTE--------YWAMQKLLSWALDSKKVP 845
            .|....|:...|.   |.:|....:|:.||..|: |..:        ..|:.|.:|...|:.|:
  Fly   763 WGSMKEWMFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKM- 826

  Fly   846 RTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSKDVKLILTPFINAMSTKAEFSALNDHLHRN 910
                 .::|.|....:||.....||.::..:|...         |.|           |.::...
  Fly   827 -----LIISTVTSRSIGYTTLLDFLSNNWDDIHHK---------FYN-----------NTNIWTK 866

  Fly   911 LPSSMVSGLSSTLESGLDRVNWRNNLYFDLLKAIRD 946
            |.|| .:|:.||.|.            :||:|...|
  Fly   867 LISS-ATGMFSTQEG------------YDLVKKFYD 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	108/476 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	79/394 (20%)
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	108/472 (23%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	83/413 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920