DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and lnpep

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_021331684.1	Gene:	lnpep / 322814	ZFINID:	ZDB-GENE-030131-1534	Length:	1026	Species:	Danio rerio

Alignment Length:	944	Identity:	205/944 - (21%)
Similarity:	373/944 - (39%)	Gaps:	199/944 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            |.|:.||:::...|.|    ..|:|.|||.:.....|:.|.|:|.::.|
Zfish   182 VHPVHYNISLHPDLNS----MTFQGNVSIVVLVMHETKNIILHSSDMNI---------------- 226

  Fly    87 GALQIK--------RIIKKTSLIKIVIELP--LRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDK- 140
                ||        |.::.....:|.|:.|  |:.|: |.|...:..||..|....|.:.|.|.
Zfish   227 ----IKVTFDDKEYRFLEYKPWQQIAIKFPEDLKKGQ-YVLKFSYKANLSNSYDGFYNSSYVDTA 286

  Fly   141 -TPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVS 204
             |.||. :||:.||..|...|||||:|.|::.:.:.:..:.||::|||||.::.....| .....
Zfish   287 GTKRVL-AATQFEPLAARKAFPCFDEPAFKSTFVVKMTREAKYISLSNMPKIKTTDLNE-NGLQE 349

  Fly   205 TTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLF 269
            ..|..|..::|..|.:.:.:...  .....:...::|::.|...:::....|....|...|.|.|
Zfish   350 DEFESSVKMSTYLVAFIVAEFSS--HSKNVSKTTVSVYAVPDKKDQVHYALETACKLLKFYNTFF 412

  Fly   270 --AYPLPKGADWGGKVDHVVLPRY-TEMYSGQGIMVYGEDIV----DSGQNGLESLQETLAELVA 327
              .|||       .|:|.|.:|.: .......|::.:.|..:    .|.:...:.:...:|..:|
Zfish   413 EIEYPL-------SKLDLVAIPDFLAGAMENWGLITFRETTLLVGNQSSRFDKQLVTSVIAHELA 470

  Fly   328 RQWNGLLVNLEDSDEEYVRNGINYY-------------------LSVQVMAMDKEAYNTTHLSKT 373
            .||.|.||.:...::.::..|...|                   |:|:..|:.|:|.|::|...|
Zfish   471 HQWFGNLVTMRWWNDLWLNEGFATYMQYMSIENVFPDLDIDIEFLNVRFKALAKDALNSSHPVST 535

  Fly   374 RLDVLYHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSA 438
            .:            |....|:|.......:|...:|: ||...|.|..|.||:.|:.:.|..|:.
Zfish   536 FV------------STPEQVEEMFDSVSYEKGASILL-MLNATLRDGEFHKGVIEYLQNYNLSNT 587

  Fly   439 SSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLD 503
            .||:||....:.:::|      :::..:|.:|....||||:||:|:..:  ||::|..:... .:
Zfish   588 ESKDLWNSLSQVSKQS------LNVSEMMNTWTVHKGFPLVTVKRNGPQ--VTLSQEHFLLN-AE 643

  Fly   504 NSSND--CWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPE---------DWLLINVDA 557
            |.::|  .|.:|:.|:..:.::           .|...::.|:.:.|         .||..|..:
Zfish   644 NGTDDSSLWHIPLTYVNDSCSV-----------LRSCKQVFHLKDKEATLQLPGQVKWLKFNFRS 697

  Fly   558 AVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETS 622
            .....|.||......:..||:.|...:|...:..|:::..:||..|::.:...||::.|:.|||
Zfish   698 DGFYIVHYDEQGWSDLISALKVDVNVLPSEDKAALINNIFALSRLGKVSFRQVLNLMDYIRNET- 761

  Fly   623 VLVWETALLN--LEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSP 685
                |||.|.  |.:|..|.|:                                     ::.:|.
Zfish   762 ----ETAPLTEALSQLGQIYRL-------------------------------------LDKRSD 785

  Fly   686 VTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLA 750
            :...||.||                      ..||...:.....:...:|:.|.::|.:.|...|
Zfish   786 LNLASSMTT----------------------YIESHFGSLMESQSWEVETSVSKMTLRSALLETA 828

  Fly   751 CQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKER 815
            |......|.|.|::.|...:....:..||.::...|.  .:....:..|..:...:..|..|.|:
Zfish   829 CALNRPNCTTQARRLFDQWLASNKTLQIPSDLMRTVF--KVAAKTDEGWSKLLGSYKHSIYDTEK 891

  Fly   816 SILLNSLSCTTE----YWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKE 876
            ..:|.:|:.|.:    .|.:||    :||..::.......::..|.|...||.....|:.::.::
Zfish   892 RKMLEALASTQDVRKIIWVLQK----SLDGSEIQNQEFPLVIHTVCRDFAGYLYAWDFMKENWEK 952

  Fly   877 I-----LRSKDVKLILTPFINAMSTKAEFSALND 905
            |     :.|..::.|:|...:..|||...:.:.:
Zfish   953 ITQKFPIGSFAIQSIITSTTSQFSTKTHLAEVQN 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	114/489 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	71/366 (19%)
lnpep	XP_021331684.1	M1_APN_2	185..620	CDD:189008	114/489 (23%)
lnpep	XP_021331684.1	ERAP1_C	690..1009	CDD:314669	72/367 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950