DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and anpepb

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001082794.1	Gene:	anpepb / 322533	ZFINID:	ZDB-GENE-030131-1253	Length:	965	Species:	Danio rerio

Alignment Length:	984	Identity:	217/984 - (22%)
Similarity:	384/984 - (39%)	Gaps:	164/984 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQ-FEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRK 85
            :.|..|.:|:..||....|... |.|..|:.....:.|.:|.::|..:||....|  .:...|..
Zfish    83 LSPETYKVTLWPRLQKNAEGLYIFTGDSSVVFRCVENTDLILIHSNKLTIKDSTT--LKALGGNP 145

  Fly    86 IGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRV-FYSAT 149
            ...:...::..||..:.|.::..|.:||.|.|...|.|.|.......|.:.|||:...: ..:.|
Zfish   146 APNIVSTKMYPKTQYMAIWLDRELTAGESYELYTEFVGELSDDLGGFYRSEYYDENGVLKVVATT 210

  Fly   150 RLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYK-EIENYVSTTFMGSPPL 213
            :::...|...|||||:|..:..:||.|:||...|||||...:||.|.. :..:...|||..:..:
Zfish   211 QMQATDARKAFPCFDEPAMKAVFNIVLLHDPGTVALSNGVVIEEIPVTVDGISLTKTTFAPTEKM 275

  Fly   214 ATQQVMWTLHQLEKVYSGPAAAGENITVWSR-----PHLAEKLAKVPEMTPNLFSKYETLFAYPL 273
            :|..:.:.:.  |..|.........|.:::|     .:..|....|.......|.:|.. .:|||
Zfish   276 STYLLAFIVS--EFTYIEQKLDDLQIRIFARKEAIDANQGEYALSVTGKILRFFEEYYN-SSYPL 337

  Fly   274 PKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGEDIV----DSGQNG-LESLQETLAELVARQWNG 332
            ||.       |.:.||.:.. .....|::.|.|..:    :...|| .|.:...:|..:|.||.|
Zfish   338 PKS-------DQIALPDFNAGAMENWGLITYRETALLYDEEMSSNGNKERVVTVIAHELAHQWFG 395

  Fly   333 LLVNLEDSDEEYVRNGINYYLSV----------------------QVMAMDKEAYNTTH-LSKTR 374
            .||.:...::.::..|...|:..                      :|.|:|  |..::| ||...
Zfish   396 NLVTIRWWNDLWLNEGFASYVEYLGADEAEPLWNIKDLIVLNDVHRVFAID--ALASSHPLSSKE 458

  Fly   375 LDVLYHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSAS 439
            .||...:.:::|           ...:...|...::.||...|.:.:|.:||:.:.:.:..::..
Zfish   459 EDVQRPEQISEV-----------FDTISYSKGASVLRMLSNFLSEDVFTQGLRTYLEHFKFNNTV 512

  Fly   440 SKELWEEFQRGARRSHQLPTGVSLP----TVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQK 500
            ..:||:..|.....     ||..||    .:|:.|:.|.|||::|:.        |:|.....:.
Zfish   513 YTDLWDHLQMAVDE-----TGTELPRSVKDIMDRWVLQMGFPVVTIN--------TVTGQISQEH 564

  Fly   501 YL--------DNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSR-DILELSHIANPEDWLLINVD 556
            :|        .:..|..|:||:.:.......||. || .|||:: |.::    .|..:|:|.|::
Zfish   565 FLLDPETKPEPSEFNYEWFVPITWTKNEAIKPQY-WL-LQKNTQFDDMK----TNANEWVLANIN 623

  Fly   557 AAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNET 621
            .....||.||..|.:.:..||:.....||.::|.||:|||.:|:.:|.:...:.|....:|..||
Zfish   624 TVGYYRVNYDEQNWERLLNALQTSRESIPVINRAQLIDDAFNLAKAGIIKTTLALRTTEFLDVET 688

  Fly   622 SVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPV 686
            ..:.|::||.||:....:...:..:...:.|::|.:.|.|:.
Zfish   689 EYMPWQSALNNLDYFYLMFDRSEVYGHMQAYIRKQVTPLFEY----------------------- 730

  Fly   687 TTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLAC 751
                  .||..|....||     :.||..|...:                          .|:||
Zfish   731 ------FTELTDWQGVPD-----NHTEQYNQVNA--------------------------LRVAC 758

  Fly   752 QFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERS 816
            ...:|.|.......|...|:.:..:.|...:|..|.|..|..|....|.....||.::....|:.
Zfish   759 SIGLKNCTDLVTSWFGEWMNNEDVNPIHANLRSTVYCSAIAAGGAEEWEFAWKMFEKTSVASEKD 823

  Fly   817 ILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILR-- 879
            .|..:::|.|:.|.:.:.|.:.||:.|:.:....|.:.::..:..|..:...|:..:.:.|..
Zfish   824 KLRAAMACATQPWLLNRYLEYTLDANKIRKQDATSTIVSIASNVGGQSLAWDFVRANWEYIFNQY 888

  Fly   880 ---SKDVKLILTPFINAMSTKAEFSAL----NDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLY 937
               |.....::.......||:.|...|    .|:.|....|..:: :..::|.....:.|.....
Zfish   889 GGGSFSFSNLINGVTKRFSTEFELKQLMQFKEDNEHIGFGSGSLA-IQQSIERTKANIKWVEQNK 952

  Fly   938 FDLLKAIRD 946
            .|:|:..:|
Zfish   953 ADVLQWFKD 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	114/492 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	78/386 (20%)
anpepb	NP_001082794.1	Peptidase_M1	78..479	CDD:279741	97/420 (23%)
		M1_APN_2	88..549	CDD:189008	114/490 (23%)
		ERAP1_C	618..940	CDD:288671	77/382 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.040