DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG2111

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	1000	Identity:	275/1000 - (27%)
Similarity:	472/1000 - (47%)	Gaps:	142/1000 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILVLFCTLLSAKLA----ESFVKPLRYNLTILTRLGSEDEQNQ----FEGIVSIDIEATQPTRVI 61
            :..||..|.:.|.|    ..::.||.|.:.|:||:      ||    |.|.|.||:.:.:.|:.|
  Fly     9 LTALFFHLEANKTAVGRLPKWLVPLSYRVDIVTRI------NQPYQPFGGTVVIDLRSERSTKRI 67

  Fly    62 YLNSLNITISRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLD 126
            .||:.::.|.::|.......:|..:....|:..| |.|.:.:.::.||:....|::.:.|:..|
  Fly    68 VLNAHDLAIGKRRAVTLSDKNGNSVPVSSIQMDI-KLSRLTVSLKRPLKVNVTYSMRVAFTSVL- 130

  Fly   127 RSQQYGYFAGYY---DKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNM 188
            |:...|:::..|   :.|...:.:||:.||::|...|||||||.||||:.|.|.|...|.|||||
  Fly   131 RNDNTGFYSSNYVDHNTTLTQWLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNM 195

  Fly   189 PPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQLEKV-YSGPAAAGENITVWSRPHLAEKLA 252
            |......:..:::||.|.|:.|.|:.|..|.:.:.:.::. ::....:...|:.|:||....:..
  Fly   196 PVQRTIRHASLKDYVWTQFVESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTE 260

  Fly   253 KVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYT-EMYSGQGIMVYGED--IVDSGQNG 314
            ....:...|.|.||.||.....:     .|:|.|.||.:| :.....|:..:.|:  :.||.::.
  Fly   261 FANMVVAPLLSFYEDLFNSTYRQ-----KKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSS 320

  Fly   315 LESLQ---ETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLS-VQVMAMDKE-AYNTTHLSKTR 374
            ::..|   ..:|.:|..||.|.||::....|.:::|....||| ..|.::..| .|...|..:..
  Fly   321 IDDQQGVARAVAMMVVNQWFGNLVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLY 385

  Fly   375 LDVLYHDSLAKVKSIATDVKESGH-----QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYA 434
            |.||.:|:......:...|.:..|     .::.::|..:|..||...:|::.:|..|:.:...||
  Fly   386 LSVLDYDAHVNTDLVTASVPDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYA 450

  Fly   435 NSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYY- 498
            |.:|:|.:.|:..|....|:.:|..|:::..:|:.|:.|||:||:||.|:...:...::|.|::
  Fly   451 NRTATSSDFWDLLQLQVDRNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFI 515

  Fly   499 -QKYLDN-SSNDCWWVPVAYIVRNLTLPQVE---------WLGC------QKNSRDILELSHIAN 546
             .::.:. :.|.|||||::|     |.|..:         ||.|      .|::..:||... |.
  Fly   516 TPQFRNRWARNPCWWVPLSY-----TCPSCQHSEIISFSRWLTCPTSKPSSKSNTVLLEKLE-AE 574

  Fly   547 PEDWLLINVDAAVPLRVFYDSYNLQLISEALR--QDFTQIPELSRIQLVDDALSLSWSGRLPYNV 609
            |.||:|.||....|.||.||..|.||:::.|.  ..|..|..::|.|||||..||:|||.:.|::
  Fly   575 PTDWILFNVQHTAPFRVNYDLRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDM 639

  Fly   610 TLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKART 674
            .|.::.||.:|...:||....::.|::.::.:....:.|||.||:.|:|..||..::|
  Fly   640 ALGILGYLEHEDEFVVWVATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISS------- 697

  Fly   675 GSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSD 739
                                   |.|.|           |.|.|..|
  Fly   698 -----------------------DLTSS-----------SGNMTHRP------------------ 710

  Fly   740 LSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRD 804
                 ::.||||::|:..|::.|::.|.....:|.......| ||.|:|..::.|.|....||..
  Fly   711 -----VIIRLACEYELPACVSLARREFMKGTPEKGGWMTIRE-RETVVCTAVKFGTEGDRDMVES 769

  Fly   805 MFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQF 869
            |:..|....|:..||.:|:|:...:|:|::|.|..:|..|.:........||:.:.:||.:.|::
  Fly   770 MYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRLAKKY 834

  Fly   870 LIDHSKEI----LRSKD-VKLILTPFINAMSTKAE---FSALNDHLHRNLPSS--MVSGLSSTLE 924
            :..:.:.|    ..|.| |..::||.|..:||..|   ||.....:.|::..|  ::..|   ||
  Fly   835 VSVNMQNIRNYCSNSTDKVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIKIL---LE 896

  Fly   925 SGLDRVNWRNNLYFDLLKAIRDFTL 949
            .|.|.::|:...:..:|:||||..|
  Fly   897 RGNDNIHWQRTKFRPMLQAIRDIIL 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	131/472 (28%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	104/389 (27%)
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	110/408 (27%)
		M1_APN_2	33..493	CDD:189008	131/472 (28%)
		ERAP1_C	579..897	CDD:288671	102/385 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850