DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG9806

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster

Alignment Length:	961	Identity:	273/961 - (28%)
Similarity:	465/961 - (48%)	Gaps:	115/961 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SFVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGR 84
            |.::||.|||::||.:........|.|.|.|.:...:.||.|.|::..:.:......:.|...||
  Fly    25 SNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRETRTIILSNNGLQVGENVLLVRRNTGGR 89

  Fly    85 KIGALQIKRIIKKTSL--IKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYY--DKTPRVF 145
                :.::::.:.:|:  :.||....|..||.|||.:.|||.|.|:.  |||.|.|  .|....:
  Fly    90 ----VTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSGQLSRAS--GYFVGGYMDSKHHPQW 148

  Fly   146 YSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGS 210
            .:.|:|.|:.|:||||||::..|..|:.:.|.|.|...|:|||..::...: |.::||.|||..:
  Fly   149 IAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVSNMRVLKTSDH-EKDDYVWTTFQQT 212

  Fly   211 PPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPLPK 275
            |.::.|::.:::::.....|.....|..:|.|.||.:|::......:||.:...:.:||..|.|
  Fly   213 PAMSVQKLAFSINRFTNRTSAEIPKGPALTTWLRPKIADQGDYAISITPQIIVFFISLFGKPYP- 276

  Fly   276 GADWGGKVDHVVLPRYT-EMYSGQGIMVYGE-DIVDSGQNGLESLQETLAELVARQ----WNGLL 334
                ..|:|.:|||... :.:...|::.|.| ..:.|.|......::.:|..||::    |   |
  Fly   277 ----AMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTRAKQQVASHVAQEFAHHW---L 334

  Fly   335 VNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTR--LDVLYHDSLAKV--KSIATDVKE 395
            .:||::...::.||::.|:|...:...:.|:....||..|  |.||..||.:..  .|:|...|.
  Fly   335 SDLENAALYWLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQALAVLVEDSKSSAYPMSLAYASKS 399

  Fly   396 SGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKR-YANSSASSKELWEEFQRGARRSHQLPT 459
            |..|  ..:|..||..||...:|.:.||..|:.:.:| :..||::...||...|..:.....|..
  Fly   400 SDTQ--ANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHKGSSSNQAFLWHTLQEESDNQMSLRQ 462

  Fly   460 GVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQK--YLDNSSNDCWWVPVAYIVRNL- 521
            .:.:..:|:||..|||:||:.|.|:.....||:||.|:.:.  .|......|||||:.:....:
  Fly   463 DIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLRNPGKLMQKRQQCWWVPLTFATAGID 527

  Fly   522 ----TLPQVEWLGCQ-KNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALR-QD 580
                |||. |||.|| :.:...|.|:.:|.|:.|::.|:..|.|.|:.||..|.|||..||. .:
  Fly   528 SFVSTLPS-EWLTCQGRQTASPLILNEVAQPDKWVVFNLRLATPCRITYDERNWQLIGNALSGTN 591

  Fly   581 FTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTG 645
            .:.|...:|.||:.|.|:|:.:|.:.|::.||.:.:|.||...:||:.|...||.|...:|.||.
  Fly   592 ASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNEDEFIVWQAADTYLEWLHRTLRQTTI 656

  Fly   646 FRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPD 710
            ...||.:|:.|::..|.....      |.||
  Fly   657 ISTFKGFMRDLLQTKFDELFK------RDGS---------------------------------- 681

  Fly   711 TTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSS 775
            ..|::|.||                      |..|:.:|:|:.:::.|...|.:.|...  ...:
  Fly   682 AAENANITE----------------------LMVIVLQLSCRTDLESCADFALKEFAGL--TLET 722

  Fly   776 SSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALD 840
            :.||.::.|.:.|..|:.|.|..|.::|.::..|...:||.|||::::|:.|.||:.|||:.|..
  Fly   723 NRIPVDLSETIYCTAIQFGTEADWTLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFA 787

  Fly   841 SKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILR-----SKDVKLILTPFINAMSTKAEF 900
            .:.:|:.....:.|||.::||||.:.|::|:|:.|.|::     :.::..::|..:..::|:.|.
  Fly   788 GRYMPKDDVLLIFSAVAQNPLGYNIAKKYLVDNIKAIIKLYGSNTDELAQLVTVLMKEVTTEEEL 852

  Fly   901 SALNDHLH---RNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLLKAIRDFT 948
            :||...:.   :|||...:: ....||.|.|.::|.|..|.:||.|:.:.|
  Fly   853 NALRMFMRTDLQNLPGFEIA-FRRILELGEDNISWHNRQYHNLLAAVCNIT 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	134/466 (29%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	101/386 (26%)
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	98/381 (26%)
		Peptidase_M1	25..392	CDD:279741	109/381 (29%)
		GluZincin	30..480	CDD:301352	134/466 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449975
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850