DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and CG31198

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	913	Identity:	204/913 - (22%)
Similarity:	358/913 - (39%)	Gaps:	210/913 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KLAESFVKPLRYNLTILTRLGSEDEQNQ--FEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIY 78
            :||| .:.|:.||:|:...|...|...:  |:|.|.|::.:.|.|..|||:|.|:|.|.:..|..
  Fly    42 RLAE-HITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYWQK 105

  Fly    79 RWASGRKIGALQIKRIIK---KTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYY-- 138
            ..........:||.....   .|.::|:.....|.:...|.|:.:::| |.....:|::...|
  Fly   106 PTTEVANPTVIQISATNTTNYDTDIVKLTASTALTANTTYILHFVYTG-LMEDDMHGFYRSSYVD 169

  Fly   139 DKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYV 203
            |.....:..:|:.:..:|...||.||:|:|:..:::||...|.:.::||...:...|..| |...
  Fly   170 DNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTE-EGIF 233

  Fly   204 STTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEK--------LAKVPEMTPN 260
            |..:..:|.::|..:.:.:.:.      .|...::..|::||....:        :..:.||...
  Fly   234 SDVYKTTPKMSTYLLAFIISEF------VARKDDDFGVYARPEYYAQTQYPYNVGIQILEEMGQY 292

  Fly   261 LFSKYETLFAYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGED--IVDSGQNGLESLQETL 322
            |...|.::       |.|   |:|...:|.::. .....|::.|.|.  :||.....|.| ::::
  Fly   293 LDKDYYSM-------GND---KMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLAS-RQSI 346

  Fly   323 AELVARQ----WNGLLVNLEDSDEEYVRNGINYYL---------------------SVQ-VMAM- 360
            |.:||.:    |.|.||..:.....::..|...|.                     .|| ||||
  Fly   347 AAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMD 411

  Fly   361 ---------DKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVA 416
                     |:..|...|||:....:.|:                        |....|.|:|..
  Fly   412 STNATNPLSDENTYTPAHLSRMFNSISYN------------------------KGATFIRMIKHT 452

  Fly   417 LGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTV 481
            :|::.|.|.|||:.|:|...|:..:.|...:|.....|..   ..|...:.:|:.:|.|:||:.|
  Fly   453 MGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPNSSY---NESSKDIFKSFTEQVGYPLINV 514

  Fly   482 QRDDAKQIVTITQSRYYQKYLDNSSNDC-WWVPVAYIVRNL-----TLPQVEWLGCQKNSRDILE 540
            ...:::  |:.||.|:..|..|.|.:.. :.||::|.....     |.|:
  Fly   515 TVGNSQ--VSFTQKRFLLKESDGSDSSLKYTVPISYTTSETNNFLNTTPK--------------- 562

  Fly   541 LSHIANPE-----------DWLLINVDAAVPLRVFYDSYNLQLISEAL-RQDFTQIPELSRIQLV 593
              .|..|.           .|:::|:......||.|...|...|..|| ..::..|.|.:|.|:|
  Fly   563 --FILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRAQIV 625

  Fly   594 DDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIE 658
            ||..:|:.:|.:.||:||:||.||..||:.:.|.:|......|  .:|:......|..|:|.|..
  Fly   626 DDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYL--TIRLGNDTADFNYYIQTLTN 688

  Fly   659 PAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDT 723
            .|:              :::..|                               |:||
  Fly   689 KAY--------------NQLGFN-------------------------------EASN------- 701

  Fly   724 TESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLC 788
                       .|..|:.|...:...||::...:|::.||..||      |.:::|:.||..|.|
  Fly   702 -----------DTALDIYLRTKILSWACRYGSSDCISQAQGYFQ------SLATVPKNIRATVYC 749

  Fly   789 RGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLL 853
            .|:|.|.|..:..:.:.|.......|.::|.||..|......::|:....: |.::.|...:|:|
  Fly   750 VGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFDLII-SDEIRRQDKSSVL 813

  Fly   854 SAV 856
            :.:
  Fly   814 ATL 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	111/505 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	71/307 (23%)
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	95/443 (21%)
		M1_APN_2	50..510	CDD:189008	111/505 (22%)
		ERAP1_C	582..898	CDD:288671	71/307 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920