DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and TRHDE

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_037513.2	Gene:	TRHDE / 29953	HGNCID:	30748	Length:	1069	Species:	Homo sapiens

Alignment Length:	977	Identity:	241/977 - (24%)
Similarity:	418/977 - (42%)	Gaps:	151/977 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            :|||.|||.:...:    |...|.|.|:::|.....||.:.|::..:.:.:     .:.|..|..
Human   190 LKPLHYNLMLTAFM----ENFTFSGEVNVEIACRNATRYVVLHASRVAVEK-----VQLAEDRAF 245

  Fly    87 GALQIKR--IIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYF-AGYYDKTPRVFYSA 148
            ||:.:..  :..:|.::.:|:...|.:...|.|.::::. |..::..|:| :.|.....|.|...
Human   246 GAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNA-LIENELLGFFRSSYVLHGERRFLGV 309

  Fly   149 TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPL 213
            |:..|.:|...|||||:|.::..:.|::.|...|::|||| |||...::| :.:|:..|..:|.:
Human   310 TQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNM-PVETSVFEE-DGWVTDHFSQTPLM 372

  Fly   214 ATQQVMWTLHQLEKVY-SGPAAAGENITVWSRPHLAEKLA--KVPEMTPNLFSKYETLF--AYPL 273
            :|..:.|.:...  .| .....:|..:.:::||....:.:  ....:|..|...||..|  .|.|
Human   373 STYYLAWAICNF--TYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSL 435

  Fly   274 PKGADWGGKVDHVVLPR--YTEMYS-GQGIMVYGEDIVDSGQNGLESLQE---TLAELVARQWNG 332
            |       |:|.:.:|:  |..|.: |..|.|....::|...:.:..|.:   .:...:..||.|
Human   436 P-------KLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFG 493

  Fly   333 LLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTRL--DVLYH----DSLAKVKSI-- 389
            .||.....::.:::.|..:|.  :.:..| ..|...::.|.|.  |||:.    |.||....:
Human   494 DLVTPVWWEDVWLKEGFAHYF--EFVGTD-YLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQ 555

  Fly   390 ----ATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRG 450
                |||: :.....:..||...||.||...:|..:|.:|||::...:...:|:..:||......
Human   556 EVLQATDI-DRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEA 619

  Fly   451 ARRSHQLPTGVSLPTVMESWMKQPGFPLLTV-QRDDAKQIVTITQSRYY------QKYLDNSSND 508
            .:|:.:.   |::..||:.|..|.|:|::|: ....|:..:.|||..:.      .|.|...:|.
Human   620 LKRNGKY---VNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNS 681

  Fly   509 -CWWVPVAYIVRN---LTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYN 569
             .|.:|:..:|.|   ::...:.|:..:.....|..|    :...|||.|::.....||.||..|
Human   682 YLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYL----DKGSWLLGNINQTGYFRVNYDLRN 742

  Fly   570 LQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLE 634
            .:|:.:.|.::...:...:|..|:|||.||:.:|.||.|:.|.:|.|||.|...|.|..|...|.
Human   743 WRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALY 807

  Fly   635 KLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDT 699
            .|..::.....:.||..|:.|.:    .||...|..        |.|..:....::|...|
Human   808 PLDKLLDRMENYNIFNEYILKQV----ATTYIKLGW--------PKNNFNGSLVQASYQHE---- 856

  Fly   700 TESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQ 764
                                                   :|....|:  |||.|..|.|   .||
Human   857 ---------------------------------------ELRREVIM--LACSFGNKHC---HQQ 877

  Fly   765 RFQAAMDQKSS--SSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTE 827
            ......|..||  :.||..:|:||.|.|:....|..|..:...|..:....|:.|||.:|:|:.:
Human   878 ASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDD 942

  Fly   828 YWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSK-------DVKL 885
            ...:.:||:.:|:|:.|.......::..|.|:|.|..:..:|..|..| ||.::       :.||
Human   943 RNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWK-ILNTRYGEALFMNSKL 1006

  Fly   886 I--LTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLL-----KA 943
            |  :|.|:|   |:.|...|.:.: :|......:..|..:|:....|.|: .||.|.|     ||
Human  1007 ISGVTEFLN---TEGELKELKNFM-KNYDGVAAASFSRAVETVEANVRWK-MLYQDELFQWLGKA 1066

  Fly   944 IR 945
            :|
Human  1067 LR 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	115/477 (24%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	98/388 (25%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	113/472 (24%)
TRHDE	NP_037513.2	ERAP1_C	723..1047	CDD:403137	99/388 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155379
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850