DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Arfgef2

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_851597.2	Gene:	Arfgef2 / 296380	RGDID:	631430	Length:	1791	Species:	Rattus norvegicus

Alignment Length:	1293	Identity:	225/1293 - (17%)
Similarity:	416/1293 - (32%)	Gaps:	507/1293 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVLFCTLLS-----AKL-AESFVKPLRYN---------------LTILTRLGSEDEQNQFEGIVS 49
            |.:|.||||     .|: .|.|.|.:..|               :..|||: ..|.|...:..|:
  Rat   463 LAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRI-CADAQCVVDIYVN 526

  Fly    50 IDIEATQPTRVIYLNSLNI--TISRQRTWIYRWASGRKIG--ALQIKRIIKK-----TSLIKIVI 105
            .|.:         ||:.||  .:....:.|.:..||.::|  .||...:.||     .|::|.::
  Rat   527 YDCD---------LNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMV 582

  Fly   106 ELPLRSGEIYTLNMLFSGNLDR----SQQYGYFAGYYDKTPRVFYSATRLEPDYA---HTVFPCF 163
            |.   |.::| :|......|.:    .|:.|...| .|...|.  |.|.:|...:   .|..|
  Rat   583 EW---SKDLY-VNPNHQATLGQERLPDQEMGDGKG-LDMARRC--SVTSVESTVSSGTQTAIP-- 638

  Fly   164 DDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQLEKV 228
            |||.     ...::..:|.:....:....:||.:.|:.......:|:   |.:.:...|||.|::
  Rat   639 DDPE-----QFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGA---AVEDIAQFLHQEERL 695

  Fly   229 YSGPAAAGENITVWSR---------------------------------PHLAEKLAKVPEMTPN 260
            .|  ...||.:...:|                                 |..|:|:.::.|   .
  Rat   696 DS--TQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLME---K 755

  Fly   261 LFSKY------ETLFAYPLPKGADWGGKVDHVVLPRYTEMYSGQ---------------GIMVYG 304
            ..::|      :||||     .||....:.:.::...|:::|.|               ||
  Rat   756 FAARYIECNQGQTLFA-----SADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGI---- 811

  Fly   305 EDIVDSGQNGLESLQE---------------TLAELVARQ------------------------- 329
            .|..|..:..|.|:.|               |:|....:|
  Rat   812 NDSKDLPEEYLSSIYEEIEGKKIAMKETKEHTMATKSTKQNVASEKQRRLLYNVEMEQMAKTAKA 876

  Fly   330 ----------------------------WNGLL----VNLEDSDEEYVRN----GINYYLSVQV- 357
                                        |..||    :.|::.|:..|.:    ||...:.:..
  Rat   877 LMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACI 941

  Fly   358 --MAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDVKE----------------------SGH 398
              |.::::||         :..|...||....|..|::|:                      |.|
  Rat   942 FGMQLERDAY---------VQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWH 997

  Fly   399 QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLP----T 459
            :.|:    |  |..|::|   :|...|::   .||.:.|...:|       |:.:.|.|.    .
  Rat   998 EILK----C--ISQLELA---QLIGTGVK---TRYLSGSGRERE-------GSLKGHSLAGEEFM 1043

  Fly   460 GVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDCWWVPVAYIVR----- 519
            |:.|..::...:             |.:|:.:      :|:.:..:|:....|.|..|..
  Rat  1044 GLGLGNLVSGGV-------------DKRQMAS------FQESVGETSSQSVVVAVDRIFTGSTRL 1089

  Fly   520 --NLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQL---------- 572
              |..:..|.|| |      .:.:..:|:|....:.::...|.:. :|:...::|
  Rat  1090 DGNAIVDFVRWL-C------AVSMDELASPHHPRMFSLQKIVEIS-YYNMNRIRLQWSRIWHVIG 1146

  Fly   573 -----------------ISEALRQ---DFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYL 617
                             ..::|||   .|.:..||:..:...|.|.       |:.      ..:
  Rat  1147 DHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLR-------PFE------HIM 1198

  Fly   618 SNETSVLVWETALLNLEKLQS--IMRMTTGFR-IFKLYMQ-------KLIEPAFKTT-------- 664
            ....|..:.:..:..:.::.|  ...:.:|:: ||.::.|       .::|.||:||
  Rat  1199 KKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIF 1263

  Fly   665 -------LNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESS------- 715
                   ::|.....:..||...|                        |..|||:..:
  Rat  1264 QHHFPAAIDSFQDAVKCLSEFACN------------------------AAFPDTSMEAIRLIRFC 1304

  Fly   716 --NTTESPDTTESSDTTESPDTTKSDLSLS-----------AILYRLACQFEIKECLTDAQQRFQ 767
              ..:|.|...:        :.|..|::::           .||:.|:|  .|..|..|.:.|..
  Rat  1305 GKYVSERPRVLQ--------EYTSDDMNVAPGDRVWVRGWFPILFELSC--IINRCKLDVRTRGL 1359

  Fly   768 AAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMF------FES----ENDKERSILLNSL 822
            ..|.:              :.:...:....||  .:|:|      |::    |...|:|..:.:
  Rat  1360 TVMFE--------------IMKSYGHTFAKHW--WQDLFRIVFRIFDNMKLPEQQSEKSEWMTT- 1407

  Fly   823 SC-----------TTEYWAMQKL--------LSWAL--DSKKVPRTMTASLLSAVLRSPLGYYVG 866
            :|           |..|.|:.::        |.|.:  |::::.|:.|..|.:.|:.:      |
  Rat  1408 TCNHALYAICDVFTQFYEALHEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISN------G 1466

  Fly   867 KQF-----------LIDHSKEILRSKDVKLILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLS 920
            ::|           ::|    |.|:....::||.....|..:.....|:..|.|...||:....|
  Rat  1467 EKFSPAVWDETCNCMLD----IFRTTIPHVLLTWRPAGMEEEVSDRHLDVDLDRQSLSSIDRNAS 1527

  Fly   921 STLESGLDRV---NWRNNLYFD-------LLKAIRDF----TLDD---GPKNSSDSDS 961
            ...:|.|...   :|:...|.:       |:|.:...    |:|:   .|..|...|:
  Rat  1528 ERGQSQLSNPTDDSWKGAPYANQKLLASLLIKCVVQLELIQTIDNIVFYPATSKKEDA 1585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	113/641 (18%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	79/494 (16%)
Arfgef2	NP_851597.2	DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250	2..224
		PLN03076	11..1718	CDD:215560	225/1293 (17%)
		DCB	28..198	CDD:292830
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..292
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..350
		Sec7_N	377..531	CDD:289549	18/77 (23%)
		HUS, DCB:HUS domain interaction. /evidence=ECO:0000250	515..535		6/28 (21%)
		Sec7	650..834	CDD:279680	35/200 (18%)
		DUF1981	1174..1255	CDD:286414	15/93 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910