DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6071 and ANPEP

DIOPT Version :9

Sequence 1:NP_648488.1 Gene:CG6071 / 39308 FlyBaseID:FBgn0036186 Length:962 Species:Drosophila melanogaster
Sequence 2:NP_001141.2 Gene:ANPEP / 290 HGNCID:500 Length:967 Species:Homo sapiens


Alignment Length:962 Identity:223/962 - (23%)
Similarity:384/962 - (39%) Gaps:142/962 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VKPLRYNLTILTRLGSEDE-QNQFEGIVSIDIEATQPTRVIYLNS--LNITISRQRTWIYRWASG 83
            :||..|.:|:...|...|. ...|:|..::.....:.|.||.::|  ||.|:|:....:.|...|
Human    80 LKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGG 144

  Fly    84 RKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVFYSA 148
            .:...:....:::.|..:.:.::..|.....|.::..|.|.|.......|.:.|.:...|...:.
Human   145 SQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVAT 209

  Fly   149 TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNM-PPVEEKPYKEIENYVSTTFMGSPP 212
            |:::...|...|||||:|..:..:||||:|.:...||||| |.....|..|..|:..|.|..:|.
Human   210 TQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPK 274

  Fly   213 LATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHL-----AEKLAKVPEMTPNLFS-KYETLFAY 271
            ::|..:.:.:.:.:.| ...|:.|..|.:|:||..     .:....|.....|.|: .|:|  .|
Human   275 MSTYLLAFIVSEFDYV-EKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDT--PY 336

  Fly   272 PLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGE-----DIVDSGQNGLESLQETLAELVARQW 330
            ||||.       |.:.||.:.. .....|::.|.|     |.:.|..:..|.:...:|..:|.||
Human   337 PLPKS-------DQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQW 394

  Fly   331 NGLLVNLEDSDEEYVRNGINYYLSVQVMAMD--KEAYNTTHLSKTRLDVLYH----DSLAKVKSI 389
            .|.||.:|..::.::..|...|  |:.:..|  :..:|...|..  |:.:|.    |:||....:
Human   395 FGNLVTIEWWNDLWLNEGFASY--VEYLGADYAEPTWNLKDLMV--LNDVYRVMAVDALASSHPL 455

  Fly   390 ATDVKESG--------HQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEE 446
            :|...|..        ...:...|...::.||...|.:.:|.:||..:...:|..:.....||:.
Human   456 STPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDH 520

  Fly   447 FQRGA-RRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSS---- 506
            .|... .||.||||.|.  .:|..|..|.|||::||.....    |::|..:   .||..|    
Human   521 LQEAVNNRSIQLPTTVR--DIMNRWTLQMGFPVITVDTSTG----TLSQEHF---LLDPDSNVTR 576

  Fly   507 ----NDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDS 567
                |..|.||:..| |:....|..||...:...|:...|    ..:|:|:|::.....||.||.
Human   577 PSEFNYVWIVPITSI-RDGRQQQDYWLIDVRAQNDLFSTS----GNEWVLLNLNVTGYYRVNYDE 636

  Fly   568 YNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLN 632
            .|.:.|...|::|.:.||.::|.|:::||.:|:.:.::|..:.||...:|..|...:.||.||.:
Human   637 ENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSS 701

  Fly   633 LEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESP 697
            |...:.:...:..:...|.|::|.:.|.|....|:    .....|||.|.....:..::.:|   
Human   702 LSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNN----TNNWREIPENLMDQYSEVNAIST--- 759

  Fly   698 DTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDA 762
                                                                ||...:.||....
Human   760 ----------------------------------------------------ACSNGVPECEEMV 772

  Fly   763 QQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMF----FESENDKERSILLNSLS 823
            ...|:..|:..:::.|...:|..|.|..|..|.|..|....:.|    ..:|.||.|:    :|:
Human   773 SGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRA----ALA 833

  Fly   824 CTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILR-----SKDV 883
            |:.|.|.:.:.||:.|:...:.:....|.:.::..:.:|..:...|:..:.|::..     |...
Human   834 CSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSF 898

  Fly   884 KLILTPFINAMSTKAEFSALNDHLHRNLPSSMVSG---LSSTLESGLDRVNW 932
            ..::.......||:.|...|......|..:...||   |...||.....:.|
Human   899 SNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKW 950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6071NP_648488.1 GluZincin 25..477 CDD:301352 120/482 (25%)
ERAP1_C 551..929 CDD:288671 79/389 (20%)
ANPEPNP_001141.2 Cytosolic Ser/Thr-rich junction 33..68
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 40..62
Metalloprotease 69..967 223/962 (23%)
M1_APN-Q_like 84..545 CDD:341064 118/476 (25%)
Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485 288..295 1/7 (14%)
Substrate binding. /evidence=ECO:0000269|PubMed:22932899 352..356 0/3 (0%)
ERAP1_C 619..946 CDD:403137 80/389 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155435
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

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