DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and ape2

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_595998.1	Gene:	ape2 / 2540648	PomBaseID:	SPBC1921.05	Length:	882	Species:	Schizosaccharomyces pombe

Alignment Length:	1025	Identity:	209/1025 - (20%)
Similarity:	382/1025 - (37%)	Gaps:	276/1025 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITI-------SRQRTWIYR 79
            |||:.|:|::...|    |...:.|.|.:.::..:.:..|.|:.:|:.|       ..|..|...
pombe    24 VKPIHYDLSLYPDL----ETFTYGGKVVVTLDVLEDSNSITLHGINLRILTAALEWGSQTVWASE 84

  Fly    80 WASGRKIGALQIKRIIKKTSLIKIVIELP--LRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTP 142
            .:.|.:                :||::.|  :.:..:..|.:.|:..:....:..|.:.|.|...
pombe    85 VSYGDE----------------RIVLQFPSTVPANSVAVLTLPFTARISSGMEGFYRSSYVDSDG 133

  Fly   143 RVFYSA-TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTT 206
            ...|.| |::||..|...|||:|:|..:..:.|.:.....|..||||..|||    .:::.:.|.
pombe   134 NTKYLATTQMEPTSARRAFPCWDEPALKATFTIDITAKENYTILSNMNAVEE----TVKDGLKTA 194

  Fly   207 -FMGSPPLATQQVMWTLHQLEKV-YSGPAAAGEN-----ITVWSRPHLAEKLAKVPEMTPNLFSK 264
             |..:..::|..:.|.:.:||.| |..|   |::     :.|::.|..:|:.....|:.......
pombe   195 RFAETCRMSTYLLAWIVAELEYVEYFTP---GKHCPRLPVRVYTTPGFSEQGKFAAELGAKTLDF 256

  Fly   265 YETLFA--YPLPKGADWGGKVDHVVLPRY-TEMYSGQGIMVYGEDIV----DSGQNGLESLQETL 322
            :..:|.  ||||       |.|.|.:|.: .......|::.|....:    ||....:|.:.|.:
pombe   257 FSGVFGEPYPLP-------KCDMVAIPDFEAGAMENWGLVTYRLAAILVSEDSAATVIERVAEVV 314

  Fly   323 AELVARQWNGLLVNLEDSDEEYVRNGI----------NYYLSVQVMAMDKEAYNTTHL-SKTRLD 376
            ...:|.||.|.||.::..|..::..|.          ::|...:|.    |:|.|.:| |...||
pombe   315 QHELAHQWFGNLVTMQFWDGLWLNEGFATWMSWFSCNHFYPEWKVW----ESYVTDNLQSALSLD 375

  Fly   377 VL----------YHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFK 431
            .|          .||  .::..|...:..|       |..| :|.|:...:|:..|:||:|::..
pombe   376 ALRSSHPIEVPIMHD--YEINQIFDAISYS-------KGSC-VIRMVSKYVGEDTFIKGIQKYIS 430

  Fly   432 RYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSR 496
            ::...:..:::||...        ...:|..:.:.|.:|.|:.|:|:|:|...:..::: |.|.|
pombe   431 KHRYGNTVTEDLWAAL--------SAESGQDISSTMHNWTKKTGYPVLSVSETNDGELL-IEQHR 486

  Fly   497 YYQKYLDNSSND--------CWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLL- 552
            :.      |:.|        .:|.|:.             |...|:.:.:::...:.:.....:
pombe   487 FL------STGDVKPEEDTVIYWAPLK-------------LKTMKDGKAVVDEKAVLSDRSKKIK 532

  Fly   553 ----------INVDAAVPLRVFYDSYNLQLISEAL--RQDFTQIPELSRIQLVDDALSLSWSGRL 605
                      :|.:.:...||.|.:.:|:.:|:..  :.|:..:.:  |..|:.|..|||.:|..
pombe   533 VDKEALESYKLNSEQSGIYRVNYSADHLKKLSQIAVEKPDYLSVED--RAGLIADVASLSRAGYG 595

  Fly   606 PYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLST 670
            ..:.||::|....:|.:.:|:...|..|..::|.:|..:...|  ..|:||:       |...:|
pombe   596 KVSSTLDLIKTWKDEPNFVVFAEMLARLNGIKSTLRFESSDII--AAMKKLV-------LEVSAT 651

  Fly   671 KART-GSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPD 734
            ||.: |.|...|....:.
pombe   652 KAHSLGWEFKANDDHIIR----------------------------------------------- 669

  Fly   735 TTKSDLSLSAILYRLACQFEIKECLTDAQQRFQA-AMDQKSSSSIPEEIREIVLCRGIRNGLEVH 798
                  ...:.:|..|..|...:.:.||..:|.| |...|  |:|.:.:|..|....||.|....
pombe   670 ------QFKSTVYNYAGLFGDDKVVKDALSKFDAYASGNK--SAINDNLRSAVFNIAIRYGGAKS 726

  Fly   799 WIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVL------ 857
            |..:.:::.::.:...|:..|.:...|.:...:||.|...||  .:.:.....|:...|
pombe   727 WDQLLEIYTKTNDPYVRNSCLRAFGVTEDEKYIQKTLDLTLD--PIVKEQDIYLILVTLSTHKNG 789

  Fly   858 -----------------RSPL-----GYYVGKQFL---------IDHSKEILRSKDVKLILTPFI 891
                             |.|:     ||.|  :|:         ||..||....||.||
pombe   790 VLAMWKFATSNWDKLLSRLPVAGTMRGYVV--RFVTSGFTHASAIDKIKEFFADKDTKL------ 846

  Fly   892 NAMSTKAEFSALNDHLHRNLPSSM--VSGLSSTLESGLDRV-NW-RNNLY 937
                           ..|.|..|:  :|..||.::..||.: .| :.|.|
pombe   847 ---------------YERALQQSLDTISANSSFIDKSLDDITRWLKENRY 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	108/496 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	82/431 (19%)
ape2	NP_595998.1	PepN	24..871	CDD:223385	205/1013 (20%)
		M1_APN_2	27..468	CDD:189008	108/496 (22%)
		ERAP1_C	541..857	CDD:288671	78/406 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910