DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and SPCC1322.05c

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_588133.1	Gene:	SPCC1322.05c / 2538917	PomBaseID:	SPCC1322.05c	Length:	612	Species:	Schizosaccharomyces pombe

Alignment Length:	722	Identity:	126/722 - (17%)
Similarity:	230/722 - (31%)	Gaps:	259/722 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EQNQFEGIVSIDIEATQPTRVI--------YLNSLNITISRQRTWIYRWASGRKIGALQIKRIIK 96
            :|....|.||..|::.:.::.:        ||...|:||:...|..               |:.|
pombe    30 DQELLHGKVSFVIQSARVSQALSHIILDTSYLEIKNVTINDIPTPF---------------RVDK 79

  Fly    97 KT----SLIKIVIELPLRSGEIYTLNMLFSGNLD--------RSQQYGYFAGYYDKTPRVFYSAT 149
            :.    |.:.||....:.|.:...|.:|:|...|        ..|..|      .|.|.||   :
pombe    80 RRGFLGSALHIVPADEIPSSKSCILTILYSTTKDCTALQFLKPEQTIG------GKFPYVF---S 135

  Fly   150 RLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLA 214
            ..:..:|.:..||.|.|..:.|.... :..:..|..|.:|                  .|:....
pombe   136 ECQAIHARSFIPCQDTPSVKVPCTFK-IRSKLPVIASGIP------------------CGTANFC 181

  Fly   215 TQQVMWTLHQ-------LEKVYSGPAAA---GENITVWSRP-----------HLAEKLAKVPEM- 257
            ...:.:...|       |..:.||..|:   |...:|::.|           |..|...:..|.
pombe   182 NGSLEYLFEQKNPIPSYLFCILSGDLASTNIGPRSSVYTEPGNLLACKYEFEHDMENFMEAAEQL 246

  Fly   258 -TPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYTEMYSGQGIMVYGEDIVDSGQNGLESLQET 321
             .|..:::|:.:.   ||....:||..:    |..|          :....:.:|.   .|....
pombe   247 TLPYCWTRYDFVI---LPPSFPYGGMEN----PNAT----------FATPTLIAGD---RSNVNV 291

  Fly   322 LAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKV 386
            :|..:|..|:|.||..|.....::..|:..:|..:::..                 ||.:...:.
pombe   292 IAHELAHSWSGNLVTNESWQCFWLNEGMTVFLERKILGR-----------------LYGEPTRQF 339

  Fly   387 KSI------ATDVK----ESGHQKL-----------------RKKKMCLLIHMLKVALGDKLFLK 424
            ::|      ...||    :|.:.||                 .:|....|..:.:|..|..:|..
pombe   340 EAIIGWGELEESVKLLGEDSEYTKLIQNLEGRDPDDAFSTVPYEKGSNFLYEIERVIGGPSVFEP 404

  Fly   425 GLQEFFKRYANSSASSKE----LWEEFQRGARRSHQLPTGVS--LPTV-MESWMKQPGFPLLTVQ 482
            .|..:|:::|.|:.:..:    |:|.|.         |.|::  |.:: .::|...||.|.:
pombe   405 FLPFYFRKFAKSTVNEVKFKHALYEYFS---------PLGLASKLDSIDWDTWYHAPGMPPV--- 457

  Fly   483 RDDAKQIVTITQSRYYQKYLDNSSND-CWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIAN 546
                            :.:.|.:..| |:.:..:            |....|||.|..:.|. .:
pombe   458 ----------------KPHFDTTLADPCYKLAES------------WTNSAKNSDDPSKFSS-KD 493

  Fly   547 PEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTL 611
            .|:|      :|....:|.|                         :|.:|:|      .|:|...
pombe   494 IENW------SAGQKSLFLD-------------------------VVYEAVS------FPHNYIK 521

  Fly   612 ---NVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKAR 673
               :|.|:..::.:.|                    .||.|||.::...:|.:.|....:.:..|
pombe   522 RMGDVYSFAESKNAEL--------------------SFRFFKLALKSKYKPLYNTIAERVGSVGR 566

  Fly   674 TGSEIPI 680
            .....||
pombe   567 MKFVRPI 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	93/513 (18%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	21/133 (16%)
SPCC1322.05c	NP_588133.1	leuko_A4_hydro	6..608	CDD:274120	126/722 (17%)
		M1_LTA4H	6..450	CDD:189006	91/508 (18%)
		Leuk-A4-hydro_C	468..607	CDD:286244	30/176 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900