DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Lnpep

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_766415.1	Gene:	Lnpep / 240028	MGIID:	2387123	Length:	1025	Species:	Mus musculus

Alignment Length:	950	Identity:	215/950 - (22%)
Similarity:	389/950 - (40%)	Gaps:	214/950 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIGA 88
            ||.|.|::...|.|    ..|.|.|:|.::|.|.||.|.|:|....|||. |::...:|..|
Mouse   174 PLCYELSLHPNLTS----MTFRGSVTISLQALQDTRDIILHSTGHNISRV-TFMSAVSSQEK--- 230

  Fly    89 LQIKRIIKKT--SLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFA-GYYDKT-PRVFYSAT 149
             |:: |::..  ..|.:|...||.:|..|||.:.:|.|:..| .||::. .|.||: .:.:::||
Mouse   231 -QVE-ILEYPYHEQIAVVAPEPLLTGHNYTLKIEYSANISNS-YYGFYGITYTDKSNEKKYFAAT 292

  Fly   150 RLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLA 214
            :.||..|.:.|||||:|.|:..:.|.:..:..:.||||||.....|.:  |..:...|..|..::
Mouse   293 QFEPLAARSAFPCFDEPAFKATFIIKITRNEHHTALSNMPKKSSVPAE--EGLIQDEFSESVKMS 355

  Fly   215 TQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVP---EMTPNLFSKYETLF--AYPLP 274
            |..|.:.:.::..:  .....|..::|::.|   ||:.:|.   :.|..|...|:|.|  .|||.
Mouse   356 TYLVAFIVGEMRNL--SQDVNGTLVSVYAVP---EKIGQVHHALDTTIKLLEFYQTYFEIQYPLK 415

  Fly   275 KGADWGGKVDHVVLPRY-TEMYSGQGIMVYGED--IVDSGQNGL---ESLQETLAELVARQWNGL 333
                   |:|.|.:|.: .......|::.:.|:  :.|:..:.:   :.:.:.:|..:|.||.|.
Mouse   416 -------KLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGN 473

  Fly   334 LVNLEDSDEEYVRNG---INYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDVKE 395
            ||.::..::.::..|   ...|.||:.:..:..:|.  .....|...:..|||.....|::.|:.
Mouse   474 LVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYE--DFLDARFKTMRKDSLNSSHPISSSVQS 536

  Fly   396 SGH-----QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSH 455
            |..     ..|...|...|:.|||..|.:.:|...:..:...::.::..|.:||:.|.....::
Mouse   537 SEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFRHAVILYLHNHSYAAIQSDDLWDSFNEVTDKT- 600

  Fly   456 QLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNS----SNDCWWVPVAY 516
                 :.:..:|::|..|.||||:||||...:  :.:.|.|::.:....|    ::..|.:|::|
Mouse   601 -----LDVKKMMKTWTLQKGFPLVTVQRKGTE--LLLQQERFFLRMQPESQPSDTSHLWHIPISY 658

  Fly   517 I--------------------VRNLTLPQVEWLGCQKNSRD--ILELSHIANPEDWLLINVDAAV 559
            :                    |.||| .||:|:....|...  |:..:|    :||
Mouse   659 VTDGRNYSEYRSVSLLDKKSDVINLT-EQVQWVKVNSNMTGYYIVHYAH----DDW--------- 709

  Fly   560 PLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNET--- 621
                      ..||::..|..:. :.:..|..|:::...|:..|::|..:..::|.||.|||
Mouse   710 ----------TALINQLKRNPYV-LSDKDRANLINNIFELAGLGKVPLRMAFDLIDYLKNETHTA 763

  Fly   622 --SVLVWETALLN--LEKLQSI---MRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIP 679
              :..:::|.|:.  ||||..:   .|:..  |:.||...::
Mouse   764 PITEALFQTNLIYNLLEKLGHMDLSSRLVA--RVHKLLQNQI----------------------- 803

  Fly   680 INTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSA 744
                                                           ...|.:.:.|.|...|.:
Mouse   804 -----------------------------------------------QQQTWTDEGTPSMRELRS 821

  Fly   745 ILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFES 809
            .|...||...::.|.|.|...|.:.|....:.|:|.::...|...|.|.  |..|:.:..|:...
Mouse   822 ALLEFACAHSLENCTTMATNLFDSWMASNGTQSLPTDVMVTVFKVGART--EKGWLFLFSMYSSM 884

  Fly   810 ENDKERSILLNSLSCTTE----YWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFL 870
            .::.|::.:|.:|:.:.:    ||.|:.    :||. .:.||..   ||.::|:...::.|....
Mouse   885 GSEAEKNKILEALASSEDVHKLYWLMKS----SLDG-DIIRTQK---LSLIIRTVGRHFPGHLLA 941

  Fly   871 IDHSKE---------ILRSKDVKLILTPFINAMSTKAEFS 901
            .|..||         .|.|..::.|:....:..|||...|
Mouse   942 WDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLS 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	121/474 (26%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	67/373 (18%)
Lnpep	NP_766415.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	107/404 (26%)
		M1_APN_2	177..617	CDD:189008	120/472 (25%)
		Substrate binding. /evidence=ECO:0000250	428..432		0/3 (0%)
		ERAP1_C	690..1005	CDD:288671	72/397 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845854
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850