DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Trhde

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	979	Identity:	241/979 - (24%)
Similarity:	419/979 - (42%)	Gaps:	155/979 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            :|||.|||.:...:    |...|.|.|:::|.....||.:.|::..:.:.:.:.     |..|..
Mouse   187 LKPLHYNLMLTAFM----ENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQV-----AEDRAF 242

  Fly    87 GALQIKR--IIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYF-AGYYDKTPRVFYSA 148
            ||:.:..  :..:|.::.:|:...|.:...|.|.::::. |..::..|:| :.|.....|.|...
Mouse   243 GAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNA-LIENELLGFFRSSYVIHGERRFLGV 306

  Fly   149 TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPL 213
            |:..|.:|...|||||:|.::..:.|::.|...|::|||| |||...::| :.:|:..|..:|.:
Mouse   307 TQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNM-PVETSVFEE-DGWVTDHFSQTPLM 369

  Fly   214 ATQQVMWTLHQLEKVY-SGPAAAGENITVWSRPHLAEKLA--KVPEMTPNLFSKYETLF--AYPL 273
            :|..:.|.:...  .| .....:|..:.:::||....:.:  ....:|..|...||..|  .|.|
Mouse   370 STYYLAWAICNF--TYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSL 432

  Fly   274 PKGADWGGKVDHVVLPR--YTEMYS-GQGIMVYGEDIVDSGQNGLESLQE---TLAELVARQWNG 332
            |       |:|.:.:|:  |..|.: |..|.|....::|...:.:..|.:   .:...:..||.|
Mouse   433 P-------KLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFG 490

  Fly   333 LLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTRL--DVLYH----DSLAKVKSI-- 389
            .||.....::.:::.|..:|.  :.:..| ..|...::.|.|.  |||:.    |.||....:
Mouse   491 DLVTPVWWEDVWLKEGFAHYF--EFVGTD-YLYPAWNMEKQRFLTDVLHEVMLLDGLASSHPVSQ 552

  Fly   390 ----ATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRG 450
                |||: :.....:..||...||.||...:|..:|.:|||::...:...:|:..:||......
Mouse   553 EVLRATDI-DRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEA 616

  Fly   451 ARRSHQLPTGVSLPTVMESWMKQPGFPLLTV-QRDDAKQIVTITQSRYYQK--------YLDNSS 506
            .||:.:.   |::..||:.|..|.|:|::|: ....|:..:.|||..:...        .|.|||
Mouse   617 LRRNGKY---VNIQEVMDQWTLQMGYPVITILGNTTAENRILITQQHFIYDIGAKTKALQLQNSS 678

  Fly   507 NDCWWVPVAYIVRN---LTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSY 568
            . .|.:|:..:|.|   ::...:.|:..:.....|..|..    ..|:|.|::.....||.||..
Mouse   679 Y-LWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRIAYLDR----GSWILGNINQTGYFRVNYDLR 738

  Fly   569 NLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNL 633
            |.:|:.:.|.::...:...:|..|:|||.||:.:|.||.|:.|.:|.|||.|...|.|..|...|
Mouse   739 NWRLLIDQLIRNHEVLSVSNRAALIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRAL 803

  Fly   634 EKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPD 698
            ..|..::.....:.||..|:.|.:    .||...|..        |.|..:....::|...|
Mouse   804 YPLDKLLDRMENYNIFNEYILKQV----ATTYIKLGW--------PRNNFNGSLVQASYQHE--- 853

  Fly   699 TTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQ 763
                                                    :|....|:  |||.|..|.|   .|
Mouse   854 ----------------------------------------ELRREVIM--LACSFGNKHC---HQ 873

  Fly   764 QRFQAAMDQKSS--SSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTT 826
            |......|..||  :.||..:|:||.|.|:....|..|..:...|..:....|:.|||.:|:|:.
Mouse   874 QASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSD 938

  Fly   827 EYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSK-------DVK 884
            :...:.:||:.:|:|:.|.......::..|.|:|.|..:..:|..|..| ||.::       :.|
Mouse   939 DRNLLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWK-ILNTRYGEALFMNSK 1002

  Fly   885 LI--LTPFINAMSTKAEFSALNDHL--HRNLPSSMVSGLSSTLESGLDRVNWR----NNLYFDLL 941
            ||  :|.|:|   |:.|...|.:.:  :..:.|:..|....|:|:   .|.|:    :.|:..|.
Mouse  1003 LISGVTEFLN---TEGELKELKNFMKSYDGVASASFSRAVETVEA---NVRWKRFYQDELFQWLG 1061

  Fly   942 KAIR 945
            ||:|
Mouse  1062 KAMR 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	116/477 (24%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	98/390 (25%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	114/472 (24%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	98/387 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845832
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950