Protein Alignment CG6071 and ENPEP

DIOPT Version :10

• Sequence 1: NP_648488.1
• Gene: CG6071 / 39308
• FlyBaseID: FBgn0036186
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Alignment Length: 1005
• Identity: 243/1005 - (24%)
• Similarity: 417/1005 - (41%)
• Gaps: 226/1005 - (22%)

  Fly    21 FVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRK 85
            ||.|:.|:|.:...|    |::.:.|.|||.|..:.|||.::|:.....|:|...  .:..||.:
Human    96 FVNPVHYDLHVKPLL----EEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPE--LKRPSGDQ 154

  Fly    86 IGALQIKRIIKKTSLIKIVI----ELPLRSGE-IYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVF 145
            :   |::|..:......:|:    ||...||: :|.|.|.|:|.|:     |...|:|    |..
Human   155 V---QVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLN-----GSLVGFY----RTT 207

  Fly   146 YS---------ATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIEN 201
            |:         ||..||..|...|||||:|..:..|.|::.|.::|.||||||..:|:...  :.
Human   208 YTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVD--DK 270

  Fly   202 YVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRP---HLAEKLAKVPEMTPNLFS 263
            :..|||..|.|::|..|.:.:||.:.| ...:.:|:.:|::.:|   |.||..|.:   |.::|.
Human   271 WTRTTFEKSVPMSTYLVCFAVHQFDSV-KRISNSGKPLTIYVQPEQKHTAEYAANI---TKSVFD 331

  Fly   264 KYETLFA--YPLPKGADWGGKVDHVVLPRY-TEMYSGQGIMVYGE-DIVDSGQNGLESLQETLAE 324
            .:|..||  |.||       |:|.:.:|.: |......|::.|.| :::...:....|.|:.:|.
Human   332 YFEEYFAMNYSLP-------KLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVAT 389

  Fly   325 LVA----RQWNGLLVNLEDSDEEYVRNGIN---YYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDS 382
            :||    .||.|.:|.::..::.::..|..   .:|.|.....|.:..:...|... |.|...||
Human   390 VVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDV-LPVQEDDS 453

  Fly   383 LAK----VKSIAT-DVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKE 442
            |..    :.::.| |...|....:...|...::.||:..:..:.|.||.|.:.::|...:|.:.:
Human   454 LMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSD 518

  Fly   443 LWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSN 507
            .|...:..:|    ||    :..||::|.:|.|:|:|.|     ..:..|||.|:   .||..:|
Human   519 FWAALEEASR----LP----VKEVMDTWTRQMGYPVLNV-----NGVKNITQKRF---LLDPRAN 567

  Fly   508 D---------CWWVPVAYIVRNLT----LPQVEWLGCQKNSRDILELSHIANPED--WLLINVDA 557
            .         .|.:||.:...|:|    ..:.|..|...||         :||..  :|.||.|.
Human   568 PSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNS---------SNPSGNAFLKINPDH 623

  Fly   558 AVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETS 622
            ....||.|:......|:.||..:........|..|:|||.:|:.:..|.|.|.||:..||..|.:
Human   624 IGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREEN 688

  Fly   623 VLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVT 687
            .|.|:..:..:..:.|:.....     :||  .:||..|:            |...||
Human   689 FLPWQRVISAVTYIISMFEDDK-----ELY--PMIEEYFQ------------GQVKPI------- 727

  Fly   688 TESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQ 752
            .:|.|..::.|                                   ..||  |..|::| ..||:
Human   728 ADSLGWNDAGD-----------------------------------HVTK--LLRSSVL-GFACK 754

  Fly   753 FEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRN-GLEVHWIMVRDMFFESENDKERS 816
            ...:|.|.:|...|:..::  .:.|:|..:|.:|...|::| |.|:.|....:.:.::...:|:.
Human   755 MGDREALNNASSLFEQWLN--GTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKE 817

  Fly   817 ILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYV-----GK--------- 867
            .||..|:.....    .|||..||..|....:....:..|:|     |:     ||
Human   818 KLLYGLASVKNV----TLLSRYLDLLKDTNLIKTQDVFTVIR-----YISYNSYGKNMAWNWIQL 873

  Fly   868 --QFLIDHSKEILRSKDVKLILT---PFINAMSTKAEFSALNDHLHR-------NLPSSMVSGLS 920
              .:|:  ::..|.::::..|:|   ||    :|:.:...:.....:       ..|...|
Human   874 NWDYLV--NRYTLNNRNLGRIVTIAEPF----NTELQLWQMESFFAKYPQAGAGEKPREQV---- 928

  Fly   921 STLESGLDRVNW----RNNL---YFDLLKA 943
              ||:..:.:.|    ||.:   :|:||::
Human   929 --LETVKNNIEWLKQHRNTIREWFFNLLES 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..472	CDD:472708	127/479 (27%)
		ERAP1_C	550..930	CDD:463368	84/406 (21%)
		SSP160	691..>749	CDD:115579	7/57 (12%)
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83
		M1_APN-Q_like	100..540	CDD:341064	127/479 (27%)
		ERAP1_C	616..934	CDD:463368	84/404 (21%)