DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6071 and ENPEP

DIOPT Version :9

Sequence 1:NP_648488.1 Gene:CG6071 / 39308 FlyBaseID:FBgn0036186 Length:962 Species:Drosophila melanogaster
Sequence 2:NP_001968.3 Gene:ENPEP / 2028 HGNCID:3355 Length:957 Species:Homo sapiens


Alignment Length:1005 Identity:243/1005 - (24%)
Similarity:417/1005 - (41%) Gaps:226/1005 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 FVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRK 85
            ||.|:.|:|.:...|    |::.:.|.|||.|..:.|||.::|:.....|:|...  .:..||.:
Human    96 FVNPVHYDLHVKPLL----EEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPE--LKRPSGDQ 154

  Fly    86 IGALQIKRIIKKTSLIKIVI----ELPLRSGE-IYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVF 145
            :   |::|..:......:|:    ||...||: :|.|.|.|:|.|:     |...|:|    |..
Human   155 V---QVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLN-----GSLVGFY----RTT 207

  Fly   146 YS---------ATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIEN 201
            |:         ||..||..|...|||||:|..:..|.|::.|.::|.||||||..:|:...  :.
Human   208 YTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVD--DK 270

  Fly   202 YVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRP---HLAEKLAKVPEMTPNLFS 263
            :..|||..|.|::|..|.:.:||.:.| ...:.:|:.:|::.:|   |.||..|.:   |.::|.
Human   271 WTRTTFEKSVPMSTYLVCFAVHQFDSV-KRISNSGKPLTIYVQPEQKHTAEYAANI---TKSVFD 331

  Fly   264 KYETLFA--YPLPKGADWGGKVDHVVLPRY-TEMYSGQGIMVYGE-DIVDSGQNGLESLQETLAE 324
            .:|..||  |.||       |:|.:.:|.: |......|::.|.| :::...:....|.|:.:|.
Human   332 YFEEYFAMNYSLP-------KLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVAT 389

  Fly   325 LVA----RQWNGLLVNLEDSDEEYVRNGIN---YYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDS 382
            :||    .||.|.:|.::..::.::..|..   .:|.|.....|.:..:...|... |.|...||
Human   390 VVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDV-LPVQEDDS 453

  Fly   383 LAK----VKSIAT-DVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKE 442
            |..    :.::.| |...|....:...|...::.||:..:..:.|.||.|.:.::|...:|.:.:
Human   454 LMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSD 518

  Fly   443 LWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSN 507
            .|...:..:|    ||    :..||::|.:|.|:|:|.|     ..:..|||.|:   .||..:|
Human   519 FWAALEEASR----LP----VKEVMDTWTRQMGYPVLNV-----NGVKNITQKRF---LLDPRAN 567

  Fly   508 D---------CWWVPVAYIVRNLT----LPQVEWLGCQKNSRDILELSHIANPED--WLLINVDA 557
            .         .|.:||.:...|:|    ..:.|..|...||         :||..  :|.||.|.
Human   568 PSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNS---------SNPSGNAFLKINPDH 623

  Fly   558 AVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETS 622
            ....||.|:......|:.||..:........|..|:|||.:|:.:..|.|.|.||:..||..|.:
Human   624 IGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREEN 688

  Fly   623 VLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVT 687
            .|.|:..:..:..:.|:.....     :||  .:||..|:            |...||       
Human   689 FLPWQRVISAVTYIISMFEDDK-----ELY--PMIEEYFQ------------GQVKPI------- 727

  Fly   688 TESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQ 752
            .:|.|..::.|                                   ..||  |..|::| ..||:
Human   728 ADSLGWNDAGD-----------------------------------HVTK--LLRSSVL-GFACK 754

  Fly   753 FEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRN-GLEVHWIMVRDMFFESENDKERS 816
            ...:|.|.:|...|:..::  .:.|:|..:|.:|...|::| |.|:.|....:.:.::...:|:.
Human   755 MGDREALNNASSLFEQWLN--GTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKE 817

  Fly   817 ILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYV-----GK--------- 867
            .||..|:.....    .|||..||..|....:....:..|:|     |:     ||         
Human   818 KLLYGLASVKNV----TLLSRYLDLLKDTNLIKTQDVFTVIR-----YISYNSYGKNMAWNWIQL 873

  Fly   868 --QFLIDHSKEILRSKDVKLILT---PFINAMSTKAEFSALNDHLHR-------NLPSSMVSGLS 920
              .:|:  ::..|.::::..|:|   ||    :|:.:...:.....:       ..|...|    
Human   874 NWDYLV--NRYTLNNRNLGRIVTIAEPF----NTELQLWQMESFFAKYPQAGAGEKPREQV---- 928

  Fly   921 STLESGLDRVNW----RNNL---YFDLLKA 943
              ||:..:.:.|    ||.:   :|:||::
Human   929 --LETVKNNIEWLKQHRNTIREWFFNLLES 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6071NP_648488.1 GluZincin 25..477 CDD:301352 129/484 (27%)
ERAP1_C 551..929 CDD:288671 84/404 (21%)
ENPEPNP_001968.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 44..83
Peptidase_M1 92..482 CDD:279741 114/417 (27%)
M1_APN_2 100..545 CDD:189008 129/484 (27%)
Substrate binding. /evidence=ECO:0000269|PubMed:23888046, ECO:0007744|PDB:4KXA, ECO:0007744|PDB:4KXB, ECO:0007744|PDB:4KXC, ECO:0007744|PDB:4KXD 357..361 0/3 (0%)
ERAP1_C 617..931 CDD:288671 83/400 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

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