DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and R03G8.6

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_510175.1	Gene:	R03G8.6 / 181438	WormBaseID:	WBGene00011000	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	164/736 - (22%)
Similarity:	289/736 - (39%)	Gaps:	158/736 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLKILVLFCTLLSAKLAE-------SFVKPLRYNLTILTRL---GSEDEQNQ--FEGIVSI--DI 52
            :|.|:..|.:.|.|::|:       ..|.|..|::.|.|.|   |.:.::|:  |||.|:|  ||
Worm     9 ILAIIKPFASELDARIADVASYRLPRHVSPSHYDIHIKTYLPGYGWKADENKITFEGNVNILLDI 73

  Fly    53 EATQPTRVIYLNSLNITIS-----RQRTWIYRW--ASGRKIGALQIKRIIKKTSLIKIVIELPLR 110
            :.|....|::.:||||..:     .|...|..|  .:..:.....:...:|..|...|.|..
Worm    74 KETTDKLVLHSSSLNIISATFQSDEQNVSISHWNVQTESQFLTFYLNNTVKVQSSAGIQINF--- 135

  Fly   111 SGEIYTLNM-LFSGNLDRSQQYGYFAGYYDKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNI 174
            .|::.|..: ||:.|..|.          |.|....: ||:.|..:|..:.||||:|.|:..:|:
Worm   136 QGKVRTDGLGLFATNSTRE----------DGTVMTNF-ATQFETIFARNMIPCFDEPEFKATWNV 189

  Fly   175 TLVHDRKYVALSNMPPVEEK--------PYK---EIENYVSTTFMGSPPLATQQVMWTLHQLEKV 228
            :|.|.....||||...||.|        .||   ::.:|:...|:|.           :...|.:
Worm   190 SLEHPTGSTALSNGIEVESKVNDDWKTTTYKKTLKMSSYILALFIGD-----------IQFKETI 243

  Fly   229 YSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFA--YPLPK-----------GA--D 278
            .:.    |..|.|::.|...:::.....::..:...:|..|.  ||:.|           ||  :
Worm   244 LNN----GVRIRVYTDPVNIDRVDHALNISRIVLEGFERQFGIRYPMEKLDFVSVQNFKFGAMEN 304

  Fly   279 WGGKVDHVVLPRYTEMYSGQGIMVYGEDIVDSGQNGLESLQETLAELVARQWNGLLVNLEDSDEE 343
            ||..:.:.        ||..|      |.:|        :.|.:...:|.||.|.||.::..|..
Worm   305 WGLVIHNA--------YSLIG------DPMD--------VTEIVIHEIAHQWFGNLVTMKYWDHI 347

  Fly   344 YVRNGI-NYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHD---------SLAKVKSIATDVKESGH 398
            ::..|. :|..|..:..:|.:....|.....:.:...:|         :|:.|.:.|..|...|
Worm   348 WLNEGFASYMTSYGLTFLDPDYQRDTFYLNCQFNPQINDGGVSLNFGKNLSSVMNNAATVYMKG- 411

  Fly   399 QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTG--- 460
                    |..:.||:...|.:.|.:.::.:.::....:....:|:|.|:..   |..|.|.
Worm   412 --------CSFVRMLENIFGTEYFNEAIKFYLEKNQYDNVDDNDLYEAFRTS---SETLDTNGKP 465

  Fly   461 VSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDC---WWVPVAYIVRNLT 522
            ..:......|..|.|||.:.|..|:.  |.|:|||..|:..|  ..|:|   |.:|:.|......
Worm   466 FDIEKFARCWTHQNGFPTIQVSNDNG--IATLTQSHLYEPQL--MLNECDYKWDIPIWYQEPGEA 526

  Fly   523 LPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPEL 587
            ..|:.||.....|.:::       .:|.::||.::.....|.|.....:.|:|.:..:.::....
Worm   527 RVQMAWLNRNSTSLELV-------ADDSVIINANSIGYYEVLYSDKMYEKIAEQVAINVSRYSVN 584

  Fly   588 SRIQLVDDALSLSWSGRLPYNVTLNVISYL----SNE----TSVLVWETALLN-----------L 633
            |..:.:.|....|..|..|::... :|:|:    .||    .|||....|:.|           :
Worm   585 SLRRTLHDVFRYSRDGLTPFHNAF-IIAYVLVFGENEILRHESVLYLVDAVYNTNNKSIVNSKDI 648

  Fly   634 EKLQSIMRMTTGFRIFKLYMQ 654
            |.::.::.....|.:|...:|
Worm   649 ETVKGLVNQIENFELFPKCVQ 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	111/505 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	24/123 (20%)
R03G8.6	NP_510175.1	Peptidase_M1	31..389	CDD:279741	94/408 (23%)
		M1_APN_2	39..482	CDD:189008	111/505 (22%)
		ERAP1_C	548..>622	CDD:288671	15/74 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850