DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and anp-1

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001041160.1	Gene:	anp-1 / 179763	WormBaseID:	WBGene00011587	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	1085	Identity:	244/1085 - (22%)
Similarity:	412/1085 - (37%)	Gaps:	271/1085 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILVLFCTLL--------------------------------SAKLAESF----------VKPLRY 27
            :|.:|||||                                :||..::.          |.|:.|
Worm    31 VLPVFCTLLGVLITAFITWHITKSQYSRNDPHDEIESENVPAAKPEDNISASELRLPTSVSPISY 95

  Fly    28 NLTILTRLG----SEDEQN-QFEGIVSIDIEATQPTRVIYLNS--LNITISRQRTWIYRWASGRK 85
            .||:.|.|.    :.|:.| .|||.|.|::..|:..:.:.|||  ||.|
Worm    96 QLTVKTYLPGYGYTADKNNLTFEGQVLIELNITKSIKKVSLNSKDLNYT---------------- 144

  Fly    86 IGALQIKRIIKKTSLI------------------KIVIEL-----PLRSGEIYTLNMLFSGNLDR 127
                  :..|||:|::                  ||...|     |..|.   ||.:.|...| |
Worm   145 ------EEFIKKSSILVNGKSIAFTLDDKQSTHEKIFFNLDETVEPTTSA---TLKVAFGAPL-R 199

  Fly   128 SQQYGYFAGYY--DKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPP 190
            :...|.:...|  .|......:.|::||.||..:.||||:|.::..:.:|::|..|.||:||  .
Worm   200 TDMSGLYQTTYTNSKGESKMAAVTQMEPVYARRMVPCFDEPAYKATWTVTVIHPNKTVAVSN--G 262

  Fly   191 VEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQLEKVYS-GPAAAGENITVWSRPHLAEKLAKV 254
            :|:|.......::.:||..:|.:::..:...:.:.|  |: ....:|....|||||.........
Worm   263 IEDKVEDGQPGFIISTFKPTPRMSSYLLAIFISEFE--YNEATTKSGVRFRVWSRPEEKNSTMYA 325

  Fly   255 PEMTPNLFSKYETLF--AYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGEDI------VDS 310
            .|........||..:  ::|||       |.|.|.||.::. .....|::.|.|..      :.|
Worm   326 VEAGVKCLEYYEKYYNISFPLP-------KQDMVALPDFSAGAMENWGLITYRESALLYDPRIYS 383

  Fly   311 GQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSK-TR 374
            |.. ...:...:|..:|.||.|.||.|:..::.::..|  :...|:.:..|:.:.....:.: ..
Worm   384 GSQ-KRRVAVVIAHELAHQWFGNLVTLKWWNDLWLNEG--FATLVEYLGTDEISDGNMRMREWFT 445

  Fly   375 LDVLYH----DSLAKVKSI------ATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEF 429
            :|.|:.    ||:|....:      |.:|.:| ...:...|...::.|::..:|::.|..|:..:
Worm   446 MDALWSALAADSVASTHPLTFKIDKAMEVLDS-FDSVTYDKGGAVLAMVRKTIGEENFNTGINHY 509

  Fly   430 FKRYANSSASSKELWEEFQRGARRSHQLPTGVSL--PTVMESWMKQPGFPLLTVQRDDAKQIVTI 492
            ..|:...:|.:..|..........|...|.||.|  ...|:.|.||.|:|||...|.:...|: :
Worm   510 LTRHQFDNADAGNLLTALGEKIPDSVMGPKGVKLNISEFMDPWTKQLGYPLLNASRINNTHII-V 573

  Fly   493 TQSRY--------YQKYLDNSSNDCW---W-VPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIA 545
            .|||:        .:||    ||..|   | |||.|.|...:..:::|:   |.:..:     |.
Worm   574 EQSRFKLLATGKEEEKY----SNPVWGFKWDVPVWYQVVGSSELEMKWM---KRNEPL-----II 626

  Fly   546 NPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVT 610
            ..:..::||.::....|..|.|...:.|||.|:::..|....:|::|:||:.:|:.:|.|.|::.
Worm   627 KSDKNVIINAESNGFYRAGYSSGLWKEISEMLKENHEQFSPQTRVRLIDDSFALARAGLLSYSIP 691

  Fly   611 LNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIE--PAFKT----TLNSLS 669
            ||:|:||.||...|.|..|:..:.:|..:........|...:|..|.|  ||.::    :.|.|.
Worm   692 LNLITYLKNEKEYLPWSGAIAKIRELIDMYGSNPEKDIVNKFMIALAENAPARRSIDFVSKNYLD 756

  Fly   670 TKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPD 734
            .|    ....:.....:...|.|..:|
Worm   757 EK----KFYEVGAAQQIILNSCGFGDS-------------------------------------- 779

  Fly   735 TTKSDLSLSAILYRLACQFEIKECLT-DAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLE-- 796
                           .||.::.:..| :...:..|.......|.||...|....|..:|||..
Worm   780 ---------------VCQADMVKMFTEEVLAKCDATRILSECSQIPAPFRAESYCEAVRNGNSDT 829

  Fly   797 ----VHWIMVRDMFFESE-NDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVP----RTMTASL 852
                .||       :::| |..|:..|:.:|:|:.:...::|||   ||:.|..    |....:.
Worm   830 FEKVFHW-------YKTERNQVEKLNLMTALTCSKDILTLKKLL---LDAMKPEGSSFRLQDCAA 884

  Fly   853 LSAVLRS-------PLGYYVG------KQFLIDHSKEILRSKDVKLILTPFINAMSTKAEFSALN 904
            |.|.:.|       .|.:.:.      |:...|||       ....:|:..:|.:.|:.....|.
Worm   885 LFAKISSNDATTDAMLNFLIDRWEDMQKRLATDHS-------GFSRVLSSIVNTLKTRGGLDQLR 942

  Fly   905 DHLHRNLPSSMVSGLSSTLESGLDRVNWR-NNLYFDLLKAIRDFT 948
             ...:..|.:...||....||....|.|| .||.| :.|.|.:.:
Worm   943 -KFRKKAPKASEFGLDKMEESAEVTVTWRETNLKF-VTKIIEEIS 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	119/506 (24%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	85/408 (21%)
anp-1	NP_001041160.1	Peptidase_M1	85..486	CDD:279741	103/441 (23%)
		M1_APN_2	93..559	CDD:189008	119/506 (24%)
		ERAP1_C	632..964	CDD:288671	85/406 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020