DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and pam-1

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001023210.1	Gene:	pam-1 / 177528	WormBaseID:	WBGene00003914	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	758	Identity:	174/758 - (22%)
Similarity:	305/758 - (40%)	Gaps:	150/758 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SFVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGR 84
            :|.:|..||:    ||.....|..|:|..:||:...:.|.|:.:::.::
Worm    82 TFAEPTHYNV----RLSPCLNQFSFDGHATIDVTIKEATDVLKVHAQSL---------------- 126

  Fly    85 KIGALQIKRIIKKTSLIK-------------------IVIELP-LRSGEIYTLNMLFSGNLDRSQ 129
                     :|:..|||.                   :.|:|| ....:...|:..|.|.|:...
Worm   127 ---------LIQSVSLITQPGDASKSLETSYDDKLNILTIKLPTTMQPQKVQLDFKFVGELNDKM 182

  Fly   130 QYGYFAGYYDKT-PRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEE 193
            :..|.:.|.||. ...|.::|:.|..||...|||||:|.::..:::||..:....|||||..:.|
Worm   183 RGFYRSQYKDKNGTEKFLASTQFESTYARYAFPCFDEPIYKATFDVTLEVENHLTALSNMNVISE 247

  Fly   194 KPYKEIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMT 258
            .|..:.:. .:.||..||.:::..|.:.:.:||.: |....:|..:.|::.|...|:.....:::
Worm   248 TPTADGKR-KAVTFATSPKMSSYLVAFAVGELEYI-SAQTKSGVEMRVYTVPGKKEQGQYSLDLS 310

  Fly   259 PNLFSKYETLF--AYPLPKGADWGGKVDHVVLPRYT-EMYSGQGIMVYGED--IVDSGQNGLESL 318
            ......|...|  .||||       |.|.:.:|.:: ......|::.|.|.  :||.|.......
Worm   311 VKCIDWYNEWFDIKYPLP-------KCDLIAIPDFSMGAMENWGLVTYREIALLVDPGVTSTRQK 368

  Fly   319 QE---TLAELVARQWNGLLVNLE-----------DSDEEYVRNGIN--------YYLSVQVMA-M 360
            ..   .:|..:|..|.|.||.::           .|..||:..|.|        ::|:.::.: |
Worm   369 SRVALVVAHELAHLWFGNLVTMKWWTDLWLKEGFASFMEYMFVGANCPEFKIWLHFLNDELASGM 433

  Fly   361 DKEAYNTTHL------SKTRLDVLYHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGD 419
            ..:|...:|.      :...||.:| ||:...||.:.:                  .||...|.:
Worm   434 GLDALRNSHPIEVEIDNPNELDEIY-DSITYAKSNSVN------------------RMLCYYLSE 479

  Fly   420 KLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTV-QR 483
            .:|.|||:.:.||:..|:|.:::||......        :|.::..:|..|.:|.|||:|.| ||
Worm   480 PVFQKGLRLYLKRFQYSNAVTQDLWTALSEA--------SGQNVNELMSGWTQQMGFPVLKVSQR 536

  Fly   484 DDA-KQIVTITQSRYYQKYLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHIANP 547
            .|. .:|:|:.|.|:.....::..|..|.||:...|.: :...|:.....|..:....:..:| |
Worm   537 QDGNNRILTVEQRRFISDGGEDPKNSQWQVPITVAVGS-SPSDVKARFLLKEKQQEFTIEGVA-P 599

  Fly   548 EDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFT--QIPELSRIQLVDDALSLSWSGRLPYNVT 610
            .:|:.:|.......||.|....|    .|:..|..  ::|.|.|..|::|..:|..:||:.....
Worm   600 GEWVKLNSGTTGFYRVEYSDEML----TAMLPDIASRRMPVLDRFGLINDLSALLNTGRVSIAQF 660

  Fly   611 LNVISYLSNETSVLVWETALLNLEKLQSIMR-------MTTGFRIFKLYMQKLIEPAF------- 661
            :.|.:..:.|...:||......:.||.:..|       .:....:.|::.|...|..|
Worm   661 VQVAASSAKEDEYVVWGAIDEGMSKLLACAREMSEDTLKSAKQLVVKMFEQTGAELGFAEQAGED 725

  Fly   662 --KTTLNSL--STKARTGSEIPINTKSPVTTE--SSGTTESPD 698
              |..|.||  :..||.|.:..|:..:.:..:  ..||...||
Worm   726 SQKMMLRSLVQARLARAGHQPTIDKFTQMFNDFLEKGTPIHPD 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	113/506 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	38/170 (22%)
pam-1	NP_001023210.1	M1_APN_2	87..529	CDD:189008	113/506 (22%)
pam-1	NP_001023210.1	ERAP1_C	602..927	CDD:314669	39/171 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020