DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Y67D8C.9

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001122826.1	Gene:	Y67D8C.9 / 177088	WormBaseID:	WBGene00022073	Length:	1144	Species:	Caenorhabditis elegans

Alignment Length:	989	Identity:	221/989 - (22%)
Similarity:	377/989 - (38%)	Gaps:	238/989 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FVKPLRYNLTILTRLGSEDEQNQFE------GIVSIDIEATQPTRVIYLNSL----------NIT 69
            ::.|..|:|.:        :.:||:      ..:||.:|:       |.||.          ||.
Worm   185 YILPYHYDLQL--------DFSQFDTHLFIRANISIHLES-------YGNSTEDEIQFHLGPNIK 234

  Fly    70 ISRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYF 134
            :.|.|.    ...|:|..|...||...| .|.:|.:..||:.|: |.|.|.::..:......|..
Worm   235 MERMRL----RKDGKKFYAKTFKREESK-KLGRISLRDPLQKGK-YILEMTYNMTICDEDVDGVR 293

  Fly   135 AGYYDKTP---RVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPY 196
            ....::|.   :.....|:.||..|...|||:|:|..:..:||::.|::||..||||||||...:
Worm   294 CSLDNQTNSSLKATSFTTKFEPTLARAFFPCWDEPGVKATFNISVRHNKKYTVLSNMPPVESHDH 358

  Fly   197 KEIENYVSTT-FMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPN 260
            |..|:...|| |..:||::|..:.:.:.:..|:.| ....|..:|||:.|.....:....|..|.
Worm   359 KSWEDQFKTTVFQTTPPMSTYLLAFAIGEFVKLES-RTERGIPVTVWTYPEDVMSMKFTLEYAPV 422

  Fly   261 LFSKYETL--FAYPLPK-----------GA--DWGGKVDHVVLPRYTEMYSGQGIMVYGEDIVDS 310
            :|.:.|..  ..|||||           |.  :||     :|:..:..:.....|..:..:.||.
Worm   423 IFDRLEDALEIPYPLPKVDLIAARNFHVGGMENWG-----LVVFEFASIAYTPPITDHVNETVDR 482

  Fly   311 GQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTRL 375
            ..|... :.:.:|...|.||.|.||.:.|..|.::..|...:...::|:.::..  |....
Worm   483 MYNEFR-IGKLIAHEAAHQWFGNLVTMRDWSELFLNEGFATFYVYEMMSTERPV--TAQFE---- 540

  Fly   376 DVLYHDSLAK--------------VKSIATD--VKESGHQKLRKKKMCLLIHMLKVALGDKLFLK 424
               |:||||.              |:.:||:  |:.|.|......|.|:||.||:..:.|..|..
Worm   541 ---YYDSLASLILAQSEEDHRLSLVRELATESQVESSFHPTNLYTKGCVLIRMLRDLVSDFDFKA 602

  Fly   425 GLQEFFKRYANSSASSKELWEEF----QRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDD 485
            .::.:.::.|..|.|..:|:...    ..||.:.       .|..|:|.|....|.|.:|:.|:.
Worm   603 AVRRYLRKNAYRSVSRDDLFASLPAYADHGAEQE-------KLSHVLEGWFVNEGIPEITLIRNY 660

  Fly   486 AKQIVTITQSR-----------------------------------------YYQKYLD------ 503
            ..:::||:|.:                                         |.:|..|
Worm   661 DNEMMTISQRKTVHHEYRSFLKDRKASASVRYRGSRSAEDGSTLFDDALFDGYIEKKKDRRRKHR 725

  Fly   504 ---------------------------NSSNDCWWVPVAYIVRNLTLPQVE-----WLGCQKNSR 536
                                       .:|.|.|.:|:.|:..:|...:.:     ||..:..|.
Worm   726 PIRRKTSTPPSISPISRRDELRKPRRVGASQDLWTIPITYMFGSLKTSEGQVIREFWLKNRTVSF 790

  Fly   537 DILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDA---LS 598
            ...|:|    |...:|:|.:...|.||.||..|.:|::..|.|:..:|.|.||:||:.||   ||
Worm   791 GDAEIS----PNQAVLVNPEWKYPYRVNYDLLNWKLLARTLHQNHLEINEKSRMQLILDAEYFLS 851

  Fly   599 LSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKT 663
            .|.:..|    .|.::.||::||.:.|....:..:.|...:.:.|...:...:|.:.:|. ....
Worm   852 NSVNPHL----YLYLLGYLAHETKMEVMLFGIDAVYKFIDVYKATQLNKAILVYFEPVIS-QMDH 911

  Fly   664 TLNSLSTKARTGSEIPIN----TKSPVTTESSGTTESPDTTESPDTAESPDT-TESSNT------ 717
            .||.....|.|.|...:.    .|......::|.:...:...:...:.|||. ||..:.
Worm   912 LLNESQVDAETASLWLVRPERLAKLYQMRCAAGLSSCKNDYYTQRWSRSPDEWTEDVHKQVTAVC 976

  Fly   718 ----TESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSI 778
                |.:||..::..     |...|.|..|...:.|..|  :..|..|.:      :.::::.:|
Worm   977 HQLFTNTPDEVKTVQ-----DLLDSRLQSSGAKWALTVQ--LAACSHDQK------LLRRTARAI 1028

  Fly   779 PEEIREIVLCRGIRNGLEVH---------WIMVRDM-FFE-----SENDKE----RSILLNSLSC 824
            ......:|....:::...:|         |..:..| .||     |.|..:    ..|||:|:..
Worm  1029 VSTKNAVVYASALQSDFSLHYNPTFRKYLWAEIAKMSTFEKTALFSTNSTDILPASRILLHSVKT 1093

  Fly   825 TTEYWAMQKLL-SW 837
            ..|...::.|| :|
Worm  1094 IDELQQIRGLLTNW 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	126/506 (25%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	73/325 (22%)
Y67D8C.9	NP_001122826.1	Peptidase_M1	182..584	CDD:279741	108/435 (25%)
Y67D8C.9	NP_001122826.1	M1_APN_2	190..652	CDD:189008	126/505 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020