DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and T16G12.1

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_499230.2	Gene:	T16G12.1 / 176416	WormBaseID:	WBGene00011803	Length:	1890	Species:	Caenorhabditis elegans

Alignment Length:	1035	Identity:	206/1035 - (19%)
Similarity:	372/1035 - (35%)	Gaps:	290/1035 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EQN-QFEGIVSIDIEATQPTRVIYLNSLNITISRQR------TWIYRWASGRKIGALQIKRIIKK 97
            |:| .|:|..||.:||...:....||:.|..|...:      |.:       .|.::......::
Worm   108 EKNFTFDGRASIQVEALVASDRFILNAYNFKIQSYKVVDIDGTVV-------PINSISQDDTTQQ 165

  Fly    98 TSLIK----IVIELPLRSGEIYTLNMLFSGNLDRSQQYG-YFAGYYDKTPRVFYS-ATRLEPDYA 156
            .|||.    :|      :|:||.:..:::|.::.....| |:..|.|......|. ||.:||..|
Worm   166 LSLITNANGVV------AGQIYNIEFVYTGIINPYTDGGVYYTSYNDPQGNTHYMIATHMEPFSA 224

  Fly   157 HTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVST-TFMGSPPLATQQVMW 220
            ..|||..|:|.::..:.||:.:....||||||  :|.:|.| |:|..|| ||..:|.:::..:.:
Worm   225 RKVFPSLDEPSYKAKFTITVQYPASQVALSNM--METEPTK-IDNIWSTITFPQTPKMSSYLIAF 286

  Fly   221 TL------------HQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPL 273
            .:            :.|.:.:..|..  |....::..:..|.|.::.|.|.         ..:||
Worm   287 AVGPYVNSQYVNKHNTLTRAWGWPGT--EQYLQFAAQNAGECLYQLGEYTG---------IKFPL 340

  Fly   274 PKGADWGGKVDHVVLPRYTEMYSGQ----GIMVYGEDIV-----DSGQNGLESLQETLAELVARQ 329
                   .|.|.:.:|   |..:|.    |:::|....:     ......:|:..:.:...:|.|
Worm   341 -------SKADQLGMP---EFLAGAMENWGLIIYKYQYIAYNPTTMTTRNMEAAAKVMCHELAHQ 395

  Fly   330 WNGLLVNLEDSDEEYVRNGI-NYYLSVQVMAMDKEAY--NTTHLSKTRLDVLYHDSLAKVKSIAT 391
            |.|.||.....|:.::..|. :|:::.    :.|..|  ..|:|.  .|.||  |.|.  ..:..
Worm   396 WFGDLVTTAWWDDLFLNEGFADYFMTF----IQKSVYPQQATYLD--TLQVL--DELQ--VGLTA 450

  Fly   392 DVKESGH----------QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEE 446
            ||:...|          ..:...|...::.||...||..:|.:|::.:.::...|:|:..:|:..
Worm   451 DVRYDAHPLVYPDGPAFDDITYNKGASMLRMLSDVLGADVFKQGIRAYLQKMQYSNANDFDLFST 515

  Fly   447 FQRGARRSH-----QLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSS 506
            ....|:.::     .||..|:  ..|:.::.|...||:....:......|.:|    :.:||.|.
Worm   516 LTDTAKSNNILDWCGLPLNVT--DFMQPYIHQTNHPLIRYNNNQKIGGSTFSQ----EPFLDISD 574

  Fly   507 ------NDCWWVPVAYIVRNLTLPQVEWL----GCQKNSRDILELSHIANPE----DWLLINVDA 557
                  |..|.:|:.........|..:||    ||...:.:|.| ..|..|.    .|.|.::.:
Worm   575 LTATPWNYTWSIPLTSANLRHADPYKQWLPRQQGCANMNENIQE-ERIKEPNKRAVQWELTSITS 638

  Fly   558 AVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGR-----LPYN-------VT 610
            |...|:.||......|.:.::||  .|.:..::.|:.|..:.....:     ..||       |.
Worm   639 ATYGRIIYDDIGFDRILKLIKQD--DINDNLKLTLLADEYNYMLREKKANRPFGYNRFLDLAKVI 701

  Fly   611 LNVISYLSNETSVLVWETALLNLEKLQSIMR--MTTGF--RIFKLYMQKLIEPAFKTTLNSLSTK 671
            .|..|: :|..|..|:..|...||::..:.|  :...|  |::||:        |:.:.|.|..:
Worm   702 FNTQSF-TNYPSYGVFAQAQPVLEQIAQLYRDGIDAEFVPRLYKLF--------FQNSYNQLKWQ 757

  Fly   672 ARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTT 736
                                                                    ||:.....|
Worm   758 --------------------------------------------------------DTSIWDTDT 766

  Fly   737 KSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSI------------PEEIREIVLCR 789
            .|::.|         .|.::..:.|.|.|.........|:.|            ...:|:.:.|
Worm   767 FSEVFL---------PFAVRYDIGDVQNRTLNMFANVKSACINSLNGTAWCNPYSTNLRKAIYC- 821

  Fly   790 GIRNGLEVHWIMVRDMFFESENDKERSI------------LLNSLSCTTEYWAMQKLLSWALDSK 842
                |...:.....|.||:..:...:.:            ||..:|||.....::.|:.....|.
Worm   822 ----GAAKYAPATSDYFFQMLHSYNKEVITNPYFYQEYMALLEGMSCTQSPATLKVLIRLFTTST 882

  Fly   843 KVPRTMTASL-----LSAVLRSPLGYYVGKQFLIDHSKEILRSKDVKLILTPFINAMS------- 895
            ..|.|:...|     .|.||   ..|::....|::.:           :|..:::||:
Worm   883 LNPSTIFGFLKYNPAASDVL---YNYFMANPQLVNST-----------MLDAYLDAMTYNWNSYF 933

  Fly   896 --------------TKAEFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLL 941
                          |..:|...:.:::|   .|::....||.  .|...||   ||.:|:
Worm   934 REGQLSTLMNTLTLTNDQFDIFDFYINR---VSLMFEYKSTY--ALPTYNW---LYDNLV 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	109/489 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	72/443 (16%)
T16G12.1	NP_499230.2	M1_APN_2	88..549	CDD:189008	109/489 (22%)
		ERAP1_C	640..931	CDD:314669	63/385 (16%)
		Peptidase_M1	999..1402	CDD:279741
		ERAP1_C	1542..1839	CDD:314669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920