DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Y53F4B.20

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_497105.3	Gene:	Y53F4B.20 / 175160	WormBaseID:	WBGene00013166	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	729	Identity:	158/729 - (21%)
Similarity:	267/729 - (36%)	Gaps:	164/729 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTI---LTRLGSED------------EQNQFEGIVSIDIEATQPTR------VIYLNS 65
            :|||.|:|.:   |:.:...|            |.||..|..|..|..:...|      :|.|:.
Worm    36 LKPLSYDLQLQLPLSEVSDPDVPLFTGRCVMHFEINQQIGPESAFISDSTSNRARIKFDIIMLDH 100

  Fly    66 L-NITISRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQ 129
            . |:::.         .:|.:   |:|..:......:::.::.|:.....|||.:.....|..|.
Worm   101 FENVSLV---------MNGHE---LEIFNVQLTDDSMELSVDQPVLFPGRYTLTIHRYKGLIGSA 153

  Fly   130 QYGYFAGYYDKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVAL---SNMPPV 191
            .|...||.:    .||  .:.|.|:.|..|||.:.....:..::||:||....:||   ||
Worm   154 IYYRDAGEH----AVF--GSNLFPNRAPAVFPSYLASTEKVTFSITMVHPVGTLALTSGSN---- 208

  Fly   192 EEKPYKEIENYVSTTFMGSPPLATQQVMWTL--HQ---LEKVYSGPAAAGENITV-WSR------ 244
            |..|.|..||:..|||..:|.:....:.:.|  |:   :|..|:     |.||:| ::|
Worm   209 EGAPRKIDENWQMTTFSTTPSITPSMLCFLLLPHEYTHIESTYT-----GVNISVHYNRFRVQKE 268

  Fly   245 --PHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYTEMYSGQGIMVYGEDI 307
              .||.....:|..:..::||.     ..|:|       |:|.:.:   .|:.|   ...:|..:
Worm   269 QTKHLLHTATQVLALLKDIFSS-----LIPVP-------KIDIITM---NEVSS---TACFGSIV 315

  Fly   308 VDSGQ---NGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTH 369
            |...|   ....:..:.||..:|:||.|....:.:..|..::..:..:::      ||.....|:
Worm   316 VSEVQFFSADYANQVKMLATWLAKQWIGGYAAISEGSELCLQEDLVAFIA------DKVIKRMTN 374

  Fly   370 LSKTRLDVLYHDSLAKVKSIATD-VKESGH-------QKLRKKKMCLLIHMLKVALGDKLFLKGL 426
            ...|||..|....|::....|.| :|...|       :|...|.:.:| ..::..:|:|..:..:
Worm   375 DEFTRLGHLAKIYLSETIFTAGDTLKLDEHPNEFEIFEKCGLKGVAML-ESIESLIGEKSMISKI 438

  Fly   427 QEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVT 491
            .|........|.||:.|:     |...| .:...:.:..::..|.:..|.|.:.|.|  ....:.
Worm   439 NEMIYNSKKGSYSSRTLY-----GLLNS-TVDEDIYVSQLLHYWHEHGGLPYMNVDR--LANSIK 495

  Fly   492 ITQSRYYQKYLDNSSN-------------DCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSH 543
            |||         |.||             ..|.:|:.:....|.:..:...|.           |
Worm   496 ITQ---------NGSNMTVKNGAGTWERMPLWPLPLKFTEFKLPIQIMVSHGI-----------H 540

  Fly   544 IANPEDWLLI-NVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPY 607
            ::...|.|:. |:......||.||....:.|...|.::.|......|.|||.|.........||.
Worm   541 LSPIRDGLIFSNLGFTNYYRVNYDIDTWREIKTVLTENATSYTLRERFQLVSDFCYFYSIKSLPE 605

  Fly   608 NVTLNVISYLSNE---------TSVLVWETALLNLEKLQSIM--RMTTGFRIFKLYMQKLIEPAF 661
            ...    |.|.||         ||..:.:.|:     .|.::  ..|....:.|..|.:|....|
Worm   606 PAA----SVLRNEFVQLVRLRPTSFPICDAAI-----FQCVVTHEHTKPRHLDKSTMVQLRRKVF 661

  Fly   662 KTTLNSLSTKARTG 675
            .:..||...:.|.|
Worm   662 DSFANSSEMECRAG 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	108/501 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	33/137 (24%)
Y53F4B.20	NP_497105.3	GluZincin	39..>300	CDD:301352	70/299 (23%)
Y53F4B.20	NP_497105.3	ERAP1_C	552..>593	CDD:288671	12/40 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910