DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and F49B2.6

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_493503.2	Gene:	F49B2.6 / 173297	WormBaseID:	WBGene00009865	Length:	1082	Species:	Caenorhabditis elegans

Alignment Length:	986	Identity:	195/986 - (19%)
Similarity:	388/986 - (39%)	Gaps:	197/986 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TLLSAKLAESFVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNI-----TI 70
            |..|::|..: .:|:.|:||:...|    ...:.|..|||.|.....|:::.||:.|:     .|
Worm   194 TWYSSRLPRT-AEPIDYDLTLHPNL----TNGEVEASVSIRILIKNDTKLLILNAENLEMKSFDI 253

  Fly    71 SRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFA 135
            :::         |.|:.|..:|..:......|:...  |..|:...|.:.:|..:....|..||:
Worm   254 TKK---------GAKVKADFVKCAVMTQWAWKLAKR--LHKGDHIVLTIYYSAQMKSDLQGLYFS 307

  Fly   136 GYY----DKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPY 196
            .:.    .||..   :||:.||.:|..:.||||:|.|:..:.:.::.:..::|.|||..:..|.|
Worm   308 THLGTDGKKTKS---AATQFEPTFARKMLPCFDEPNFKATFQVAIIRNPHHIARSNMNILISKEY 369

  Fly   197 KEIENYVSTTFMGSPPLAT----------------------QQVMWTLHQLEKVYSGPAAAGENI 239
            |  ...:...|..|..::|                      :.:...|:..:.:.:|.:..|.:.
Worm   370 K--NGLIKDVFEKSVKMSTYLLAVAVLDGYGYIKRLTRNTQKAIEVRLYAPQDMLTGQSEFGLDT 432

  Fly   240 TVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVY 303
            |:           :..|...:.|:     .:|||       .|:|.:.|..::| .....|::.:
Worm   433 TI-----------RALEFFEDYFN-----ISYPL-------DKIDLLALDDFSEGAMENWGLVTF 474

  Fly   304 GEDIVDSGQN-----GLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKE 363
            .:..:...:.     ..|.:...:...:|.||.|.||.::..:|.::..|...|:..:.:
Worm   475 RDSALLFNERKASVVAKEHIALIICHEIAHQWFGNLVTMDWWNEVFLNEGFANYMEYKCV----- 534

  Fly   364 AYNTTHL--SKTRLDVLYHDSLA---------KVKSIATDVKES---GHQKLRKKKMCLLIHMLK 414
                .||  ..:.:...|.::||         ..::|.:|..:|   ....:...|...:|||:.
Worm   535 ----EHLFPDWSIMSRFYAENLAFSQEPDGFLSSRAIESDDDDSLLNLFDAINYHKAAAIIHMIA 595

  Fly   415 VALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLL 479
            ...|.|.|...|.|:..:||.|:|...:||:..::.|    .|...||:|.:.:::..|.|:|||
Worm   596 EMAGQKNFQNALVEYLNKYAYSNAIGVDLWKIVEKHA----NLQGTVSIPDLAKAYTTQVGYPLL 656

  Fly   480 TVQRDDAKQIVTITQSRYY----QKYLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILE 540
            ||:|.| :.::...|:|:.    .|..:...:..|.:|::|........:..|:  |.:.:::
Worm   657 TVERTD-EGVLVHNQTRFLFAEGDKAEEKRGDWKWPIPISYRDSEHRRKKQHWI--QADDKNV-- 716

  Fly   541 LSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRL 605
             :......|||::|.......:|.||....:.:.:.|:::.|.|..:.|..::.|:..||.:..|
Worm   717 -TWETTSNDWLILNTGGVGYFKVLYDPETYRKLVKQLQRNHTTISPIDRSMILVDSFDLSKTSLL 780

  Fly   606 PYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLST 670
            ..:|..:::.|:..||..:.|......|..:::::..:....|::.:.:.||...:
Worm   781 NISVYFDLLEYVEKETDKMTWSIVGKQLRTIEALIEESDYLDIYQDFQRSLIMRLY--------- 836

  Fly   671 KARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDT 735
                                    ||.|..|           :.:|..:.
Worm   837 ------------------------ESLDWDE-----------QGANPNQK--------------- 851

  Fly   736 TKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWI 800
                 .|...::.:||:.:||:|...|.||:   :...||.....|...|.|..|::.|....|.
Worm   852 -----RLQVDIFAVACRLQIKDCTKQAYQRY---LQWVSSGVRNPEHHMIALMEGVKQGETTAWE 908

  Fly   801 MVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSK----KVPRTMTASLLSAVLRSPL 861
            .:...:..:.:..|::.::.:|:.|.:...:.:||.:.||.|    .:||..:...|:...|:.:
Worm   909 RIWKAYKTATSPSEKNNIIGALTSTKDASLINRLLKYCLDGKIKANLIPRVFSYFSLNQSTRNIV 973

  Fly   862 GYYVGKQFLIDH---SKEILRSKDVKLILTPFINAMSTKAEFSALNDHL-HRNLPSSMVSGLSST 922
            ..:....|...|   .|..|.:..||.:..|    :||:.|...:.:.| .:......:..:..|
Worm   974 WKFFKTHFEQFHGILGKGSLMASCVKCLAEP----LSTETELEEVKEFLKSQKFAEDGLIKMEMT 1034

  Fly   923 LESGLDRVNWR 933
            .|.....:.||
Worm  1035 YEQIELNIQWR 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	103/502 (21%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	69/385 (18%)
F49B2.6	NP_493503.2	Peptidase_M1	199..586	CDD:279741	83/439 (19%)
		M1_APN_2	207..654	CDD:189008	103/502 (21%)
		ERAP1_C	726..1037	CDD:288671	68/381 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920