DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Lnpep

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001106874.1	Gene:	Lnpep / 171105	RGDID:	621752	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	216/938 - (23%)
Similarity:	387/938 - (41%)	Gaps:	182/938 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIGA 88
            |.||.|::...|.|    ..|.|.|:|.::|.|.||.|.|:|....|| ..|::...:|..|
  Rat   174 PQRYELSLHPNLTS----MTFRGSVTISLQALQDTRDIILHSTGHNIS-SVTFMSAVSSQEK--- 230

  Fly    89 LQIKRIIKKTSLIKIVIELP--LRSGEIYTLNMLFSGNLDRSQQYGYFA-GYYDKT-PRVFYSAT 149
             |:: |::.....:|.:..|  |.:|..|||.:.:|.|:..| .||::. .|.||: .:..::||
  Rat   231 -QVE-ILEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNS-YYGFYGITYTDKSNEKKNFAAT 292

  Fly   150 RLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLA 214
            :.||..|.:.|||||:|.|:..:.|.:..|..:.||||||.....|.:  |..:...|..|..::
  Rat   293 QFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTE--EGLIQDEFSESVKMS 355

  Fly   215 TQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLF--AYPLPKGA 277
            |..|.:.:.::..:  .....|..::|::.|...:::....:.|..|...|:..|  .|||.
  Rat   356 TYLVAFIVGEMRNL--SQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLK--- 415

  Fly   278 DWGGKVDHVVLPRY-TEMYSGQGIMVYGED--IVDSGQNGL---ESLQETLAELVARQWNGLLVN 336
                |:|.|.:|.: .......|::.:.|:  :.|:..:.:   :.:.:.:|..:|.||.|.||.
  Rat   416 ----KLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVT 476

  Fly   337 LEDSDEEYVRNG---INYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDVKESGH 398
            ::..::.::..|   ...|.||:.:..:..:|.  .....|...:..|||.....|::.|:.|..
  Rat   477 MQWWNDLWLNEGFATFMEYFSVEKIFKELNSYE--DFLDARFKTMRKDSLNSSHPISSSVQSSEQ 539

  Fly   399 -----QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLP 458
                 ..|...|...|:.|||..|.:.:|...:..:...::.::..|.:||:.|..        .
  Rat   540 IEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNE--------V 596

  Fly   459 TGVSLPT--VMESWMKQPGFPLLTVQRDDAKQIVTITQSRYY----QKYLDNSSNDCWWVPVAYI 517
            ||.:|..  :|::|..|.||||:||||...:  :.:.|.|::    .:..|:.::..|.:|::|:
  Rat   597 TGKTLDVKKMMKTWTLQKGFPLVTVQRKGTE--LLLQQERFFPSMQPEIQDSDTSHLWHIPISYV 659

  Fly   518 VRNLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFY--DSYNLQLISEALRQD 580
            .......:...:.......|::.|:   ....|:.:|.:......|.|  |.: ..||::..|..
  Rat   660 TDGRNYSEYRSVSLLDKKSDVINLT---EQVQWVKVNTNMTGYYIVHYAHDGW-AALINQLKRNP 720

  Fly   581 FTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNET-----SVLVWETALLN--LEKLQS 638
            :. :.:..|..|:::...|:..|::|..:..::|.||.|||     :..:::|.|:.  ||||..
  Rat   721 YV-LSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGH 784

  Fly   639 I---MRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTT 700
            :   .|:.|  |:.||...::
  Rat   785 MDLSSRLVT--RVHKLLQNQI-------------------------------------------- 803

  Fly   701 ESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQR 765
                                      ...|.:.:.|.|...|.:.|...||...::.|.|.|.:.
  Rat   804 --------------------------QQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKL 842

  Fly   766 FQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMF----FESENDKERSILLNSLSCTT 826
            |...|....:.|:|.::...|...|.|.  |..|:.:..|:    .|:|.||....|.:|.....
  Rat   843 FDGWMASNGTQSLPTDVMTTVFKVGART--EKGWLFLFSMYSSMGSEAEKDKILEALASSADAHK 905

  Fly   827 EYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQF---LI--DHSKE---------I 877
            .||.|:.    :||. .:.||..   ||.::|:     ||:||   |:  |..||         .
  Rat   906 LYWLMKS----SLDG-DIIRTQK---LSLIIRT-----VGRQFPGHLLAWDFVKENWNKLVHKFH 957

  Fly   878 LRSKDVKLILTPFINAMSTKAEFSALND 905
            |.|..::.|:....:..|||...|.:.:
  Rat   958 LGSYTIQSIVAGSTHLFSTKTHLSEVQE 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	119/473 (25%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	80/385 (21%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	102/401 (25%)
		M1_APN_2	176..617	CDD:189008	119/472 (25%)
		Substrate binding. /evidence=ECO:0000250	428..432		0/3 (0%)
		ERAP1_C	690..1005	CDD:288671	80/385 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850