DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Lta4h

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_032543.2	Gene:	Lta4h / 16993	MGIID:	96836	Length:	611	Species:	Mus musculus

Alignment Length:	614	Identity:	124/614 - (20%)
Similarity:	225/614 - (36%)	Gaps:	141/614 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LTRLGSEDEQNQFEGIVSIDIEATQPT-RVIYLNSLNI--TISRQRTWIYRWASGRKIGALQIKR 93
            ||...:...|:|.|.:.|:.::....| ..:.:|...:  |:..        :.|.|...::|..
Mouse    35 LTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGE--------SQGYKGSPMEISL 91

  Fly    94 IIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVFYSATRLEPDYAHT 158
            .|..:...:||||:...:....:.....:......:|:.|.             .::.:..:...
Mouse    92 PIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKQHPYL-------------FSQCQAIHCRA 143

  Fly   159 VFPCFDDPRFRTPYNITLVHDRKYVALSNM-----PPVEEKPYKEIENYVSTTFMGSPPLATQQV 218
            :.||.|.|..:..|...:...::.|||.:.     .|..|.|.::|..     |....|:....:
Mouse   144 ILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYR-----FNQRVPIPCYLI 203

  Fly   219 MWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGAD--WGG 281
            ...:..||....||     ...|||.....||.|       |.||:.|::.......|..  | |
Mouse   204 ALVVGALESRQIGP-----RTLVWSEKEQVEKSA-------NEFSETESMLKIAEDLGGPYVW-G 255

  Fly   282 KVDHVVLPRYTEMYSGQGIMVYGED-----IVDSGQNGLESLQETLAELVARQWNGLLVNLEDSD 341
            :.|.:|||. :..|.|.      |:     :..:...|.:||...:|..::..|.|.||..:..|
Mouse   256 QYDLLVLPP-SFPYGGM------ENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWD 313

  Fly   342 EEYVRNGINYYLSVQVMAM---DK-----------EAYNT------TH-LSKTRLDVLYHDSLAK 385
            ..::..|...||...:...   :|           |..||      :| .:|..:|
Mouse   314 HFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVD--------- 369

  Fly   386 VKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRG 450
            :|.:..||..|...  .:|...||.::.::..|.::||..|:.:.|:::..|.::.: |:.|
Mouse   370 LKDVDPDVAYSSIP--YEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDD-WKSF--- 428

  Fly   451 ARRSHQLPTGVSLPTVME--SWMKQPGFPLLTVQRDDAKQIVTITQS--RYYQKYLDNSSNDCWW 511
             ..|| ....|.|...::  :|:..||.|.:....|     ||:|.:  ...|:::.....|...
Mouse   429 -LYSH-FKDKVDLLNQVDWNTWLYAPGLPPVKPNYD-----VTLTNACIALSQRWVTAKEEDLSS 486

  Fly   512 VPV---------------AYIVRNLTLPQVEWLGCQKNSRDILELSHIANPE---DWLLINV--- 555
            ..:               |.:::...||    ||..|..:::...:.|.|.|   .||.:.:
Mouse   487 FSIADLKDLSSHQLNEFLAQVLQKAPLP----LGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSK 547

  Fly   556 -DAAVPLRVFYDSYNLQLISEALRQDFTQ 583
             :.|:||.       |::.:|..|..||:
Mouse   548 WEEAIPLA-------LKMATEQGRMKFTR 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	98/482 (20%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	9/37 (24%)
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	124/614 (20%)
		M1_LTA4H	6..450	CDD:189006	96/477 (20%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	135..137		0/1 (0%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	267..272		2/10 (20%)
		Leuk-A4-hydro_C	468..607	CDD:286244	21/113 (19%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	564..566		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900