DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Anpep

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	961	Identity:	218/961 - (22%)
Similarity:	394/961 - (40%)	Gaps:	144/961 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 FEGIVSIDIEATQPTRVIYLNS--LNITISRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIE 106
            |:|..::.....|.|.||.::|  ||.|:......:.|...|.....:....::::|..:.:.::
Mouse   103 FQGNSTVRFTCNQTTDVIIIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQ 167

  Fly   107 LPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTP 171
            ..|..|..|.::..|.|.|.......|.:.|.:...:...:.|:::...|...|||||:|..:..
Mouse   168 GSLVEGRQYEMDSQFQGELADDLAGFYRSEYMEGDVKKVVATTQMQAADARKSFPCFDEPAMKAM 232

  Fly   172 YNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAG 236
            :||||::....:|||||.|.|.|||.|..:...|.|..:|.::|..:.:.:.:.:.: |..:|.|
Mouse   233 FNITLIYPNNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNI-SSVSANG 296

  Fly   237 ENITVWSRPHLAEK-----LAKVPEMTPNLFSK-YETLFAYPLPKGADWGGKVDHVVLPRYTE-M 294
            ..|.:|:||...::     ...|.....|.|:: |.|  :|||||.       |.:.||.:.. .
Mouse   297 VQIGIWARPSAIDEGQGDYALNVTGPILNFFAQHYNT--SYPLPKS-------DQIALPDFNAGA 352

  Fly   295 YSGQGIMVYGED--IVDSGQNGL---ESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLS 354
            ....|::.|.|.  :.||..:.:   |.:...:|..:|.||.|.||.:...::.::..|...|
Mouse   353 MENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASY-- 415

  Fly   355 VQVMAMD--KEAYNTTHLSKTRLDVLYH----DSLAK---VKSIATDVKESGH-----QKLRKKK 405
            |:.:..|  :..:|...|..  |:.:|.    |:||.   :.|.|.::|....     ..:...|
Mouse   416 VEYLGADYAEPTWNLKDLMV--LNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSK 478

  Fly   406 MCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESW 470
            ...:|.||...|.:.||.|||..:...|..|:....:|||..|:...:...:....::.|:|:.|
Mouse   479 GASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRW 543

  Fly   471 MKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSS--------NDCWWVPVAYIVRNLTLPQVE 527
            :.|.|||::||..:..:    |:|..:   .||:.|        |..|..|:.:    |...|.:
Mouse   544 ILQMGFPVITVNTNTGE----ISQKHF---LLDSKSNVTRPSEFNYIWIAPIPF----LKSGQED 597

  Fly   528 --WLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRI 590
              ||..:||.....:.|    ..:|:|:|::......|.||..|.:.:...|:.|.:.||.::|.
Mouse   598 HYWLDVEKNQSAKFQTS----SNEWILLNINVTGYYLVNYDENNWKKLQNQLQTDLSVIPVINRA 658

  Fly   591 QLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQK 655
            |::.|:.:|:.:..:|..:.|:...:|..|...:.|:.||.:|.....:...:..:...|.|::|
Mouse   659 QIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKK 723

  Fly   656 LIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTES 720
            .:.|.|....|      ||.:.:                           ...|...|..|...:
Mouse   724 QVTPLFFYFQN------RTNNWV---------------------------NRPPTLMEQYNEINA 755

  Fly   721 PDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREI 785
            ..|                          ||...:|||.....:.:...|...::::|...:|..
Mouse   756 IST--------------------------ACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRST 794

  Fly   786 VLCRGIRNGLEVHWIMVRDMF----FESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPR 846
            |.|..|..|.|..|....:.|    ..:|.||.||    :|:|:.:.|.:.:.||:.|:...:.:
Mouse   795 VYCNAIAFGGEEEWNFAWEQFRNATLVNEADKLRS----ALACSKDVWILNRYLSYTLNPDYIRK 855

  Fly   847 TMTASLLSAVLRSPLGYYVGKQFLIDHSKEILR-----SKDVKLILTPFINAMSTKAEFSALNDH 906
            ..|.|.:.::..:..|:.:...|:..:.|::..     |.....::.......|::.|...|...
Mouse   856 QDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQF 920

  Fly   907 LHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLLKAIRDFTLDDGPKNSS 957
            ...|..:...:| :..||..|::.  |.|:  |.:|..:|.......:|||
Mouse   921 KADNSATGFGTG-TRALEQALEKT--RANI--DWVKENKDAVFKWFTENSS 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	116/460 (25%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	74/386 (19%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64
		Metalloprotease	69..966		216/959 (23%)
		M1_APN-Q_like	84..545	CDD:341064	114/455 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		0/3 (0%)
		ERAP1_C	618..945	CDD:403137	75/392 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940