DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and Enpep

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_031960.1	Gene:	Enpep / 13809	MGIID:	106645	Length:	945	Species:	Mus musculus

Alignment Length:	889	Identity:	212/889 - (23%)
Similarity:	378/889 - (42%)	Gaps:	181/889 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRK 85
            |:.|:.|:|.:...:    |::::.|||:|.:..::|||.::|:.....|::...  .|..||.:
Mouse    88 FINPVHYDLEVKALM----EEDRYTGIVTISVNLSKPTRDLWLHIRETKITKLPE--LRRPSGEQ 146

  Fly    86 IGALQIKRIIKKTSLIKIVI----ELPLRSGE-IYTLNMLFSGNLDRSQQYGYFAGYYDKTPRVF 145
            :   .|:|..:......:||    :|...||: :|.|.|.|.|.|:     |...|:|..|
Mouse   147 V---PIRRCFEYKKQEYVVIQAAEDLAATSGDSVYRLTMEFKGWLN-----GSLVGFYKTT---- 199

  Fly   146 Y---------SATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIEN 201
            |         :||..||..|...|||||:|..::.|:|:::|.::|.||||||  |||.....:|
Mouse   200 YMEDGQIRSIAATDHEPTDARKSFPCFDEPNKKSTYSISIIHPKEYSALSNMP--EEKSEMVDDN 262

  Fly   202 YVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYE 266
            :..|||:.|.|::|..|.:.:|:...: ...:.:|:.:.|:.:|:..|.......:|..:|..:|
Mouse   263 WKKTTFVKSVPMSTYLVCFAVHRFTAI-ERKSRSGKPLKVYVQPNQKETAEYAANITQAVFDYFE 326

  Fly   267 TLFA--YPLPKGADWGGKVDHVVLPRY-TEMYSGQGIMVYGE-----DIVDSGQNGLESLQETLA 323
            ..||  |.||       |:|.:.:|.: |......|::.|.|     |.:.|..:..:.:...:|
Mouse   327 DYFAMEYALP-------KLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVA 384

  Fly   324 ELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTRLDVLY----HDSLA 384
            ..:..||.|..|.::..|:.::..|...:.  :.:.::....:...||:..|:.::    .|||.
Mouse   385 HELVHQWFGNTVTMDWWDDLWLNEGFASFF--EFLGVNHAEKDWQMLSQVLLEDVFPVQEDDSLM 447

  Fly   385 K----VKSIATDVK-ESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELW 444
            .    |.:::|..: .|....:...|...::.||:..:..:.|.||.|.:.|::..::|.:.:.|
Mouse   448 SSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLKKFQFANAKTSDFW 512

  Fly   445 EEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSND- 508
            :..|..:    .||    :..||::|..|.|:|::||   ..:|  .|||.|:   .||:.::.
Mouse   513 DSLQEAS----NLP----VKEVMDTWTSQMGYPVVTV---SGRQ--NITQKRF---LLDSKADPS 561

  Fly   509 --------CWWVPVAYIVRNLTLPQVEWLGCQKNSRDI---------LELSHIANPEDWLLINVD 556
                    .|.:|            |.|.. ..|||..         :.|:...:.:.:|.||.|
Mouse   562 QPPSELGYTWNIP------------VRWAD-NDNSRITVYNRLDKGGITLNANLSGDAFLKINPD 613

  Fly   557 AAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNET 621
            .....||.|:......|:|||..:.|:.....|...:|||.:|:.:..|.|.:.||:..||.:|.
Mouse   614 HIGFYRVNYEGGTWDWIAEALSSNHTRFSAADRSSFIDDAFALARAQLLNYKIALNLTMYLKSEE 678

  Fly   622 SVLVWETALLNLEKLQSIMRMTTG-FRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSP 685
            ..|.||..:.::..:.|:...... :.:.:.|.|..::|     :..|.....|||.|
Mouse   679 DFLPWERVISSVSYIISMFEDDRELYPMIETYFQGQVKP-----VADLLGWQDTGSHI------- 731

  Fly   686 VTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLA 750
                                                              ||   .|.|.:...|
Mouse   732 --------------------------------------------------TK---LLRASILGFA 743

  Fly   751 CQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRN-GLEVHWIMVRDMFFESENDKE 814
            |:...:|.|.:|.|.|.:.:  |.|:|||..:|.:|...|::| |.|..|....:.:.::...:|
Mouse   744 CKMGDREALGNASQLFDSWL--KGSASIPVNLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQE 806

  Fly   815 RSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLR 858
            :..||..|:...:.    |||:..|:..|.|..:....:..|:|
Mouse   807 KEKLLYGLASVKDV----KLLARYLEMLKDPNIIKTQDVFTVIR 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	121/482 (25%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	71/310 (23%)
Enpep	NP_031960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..77
		Peptidase_M1	84..474	CDD:279741	105/415 (25%)
		M1_APN_2	92..537	CDD:189008	121/482 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		0/3 (0%)
		ERAP1_C	608..922	CDD:288671	71/310 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910