DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and AgaP_AGAP003926

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_318379.5	Gene:	AgaP_AGAP003926 / 1278754	VectorBaseID:	AGAP003926	Length:	876	Species:	Anopheles gambiae

Alignment Length:	986	Identity:	204/986 - (20%)
Similarity:	378/986 - (38%)	Gaps:	210/986 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLRYNLTI-LTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIG 87
            ||.|:|.: .|.||..|  ..:.|.|||.|.....|..:.|:::..|:  :...:.|...|..|
Mosquito    29 PLHYDLHLEATGLGLHD--YTYRGNVSIRIAIVSDTNEVVLHNVGNTL--ESICLRRCRDGEAI- 88

  Fly    88 ALQIKRIIKKTSLIKIVIELPLR--SGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRV--FYSA 148
            :.|:......:.|::|..:..||  ..::.||.::|...|...:. |::...|....|:  ..:.
Mosquito    89 SHQLLESEPASELLRIRTDRILRRADDQVITLTIVFHNTLGEDRM-GFYRTQYRGAKRIPMAVAT 152

  Fly   149 TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPL 213
            |..:|.||...|||||:|.|:|.:.||:|.:..::..|| .|:....:.: :.:.:..|..:||:
Mosquito   153 THFQPSYARLAFPCFDEPGFKTTFQITIVANGSHLVASN-APIATVTWLQ-DGHKAVRFERTPPM 215

  Fly   214 ATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGAD 278
            .|..|.:.:.....|:: .:.:|..|.:.:.|...:.|....:....|.|..|..      .|..
Mosquito   216 QTYLVTFLIANFTSVHT-VSPSGVEIGILAPPKDEKSLQFSLQAATALLSSLEEY------TGQS 273

  Fly   279 WG-GKVDHVVLPRYTEMYSGQGIMVYGED--IVDSGQNGLESLQE--TLAELVARQWNGLLVNLE 338
            .| .|:|||.:||:.......|::.|.|.  ::.:..:.|:..|.  |:....|.|..|.||...
Mosquito   274 LGLQKLDHVAIPRFGNAMENWGLVAYDEQFLVLSAKAHRLQRAQAVLTIGHETAHQLFGNLVGPA 338

  Fly   339 DSDEEYVRNGINYYLSVQVMAMD--------KEAYNTTHLSKTRLDVLY--HDSLAKVKSIATDV 393
            .....::..|...|..: ::..|        :|::...|:....:...|  |....:..|..|..
Mosquito   339 WWSYLWLSEGFATYFEL-LLGADAYPELLPLEESFAVRHMHPALMADAYEQHPLTVEPLSANTPE 402

  Fly   394 KESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLP 458
            .|:....:...|...::.|:..::|::.|..|:|.:.:::.|...:.::|:..|  ..::....|
Mosquito   403 IETLFDTITYSKAGCILRMINCSIGEEAFQAGVQNYLEQHRNGVVTPEDLYASF--SVQQQRDTP 465

  Fly   459 TGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYY-QKYLDNSSNDCWWVPVAYIVRNLT 522
            |   :..:..||:.:||:|::||:|.:. ..|...|.||: |:.........|::|:.|.. |.:
Mosquito   466 T---VEQMFRSWVDKPGYPVVTVERLNG-SFVRFRQQRYHNQEVTTQDITSRWFIPITYYT-NSS 525

  Fly   523 LPQVE-----WLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFT 582
            |.|.|     |:   |.:...|.|....|.:|.|::|.......||.||......|.:.|    |
Mosquito   526 LGQYEYQPAFWM---KETDQELVLQLEMNTQDVLVVNPRQIGFYRVEYDERGWSSIVDNL----T 583

  Fly   583 QIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALL--NLEKLQSIM----- 640
            .:|.:.:.:|:|||..|:.:|.:.|.:.|.::..|:.....:.|..|:.  |:..||.::
Mosquito   584 TLPSIMQAKLIDDAFVLARAGLVGYELCLEMLQELATSPDPVPWLIAMAEENIGYLQRVLQSAEF 648

  Fly   641 -RMTTGF--RIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTES 702
             |..|||  .:|.|
Mosquito   649 DRFLTGFVGEMFDL--------------------------------------------------- 662

  Fly   703 PDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILY----RLACQFEIKECLTDAQ 763
                       :.|...:...:::.|                :.|    |||..|
Mosquito   663 -----------AGNVGRTLLQSQALD----------------VAYDWWSRLAASF---------- 690

  Fly   764 QRFQAAMDQKSSSSI------PEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSL 822
                  ::.|..|||      |..::|:|                  ....|.:|..|..|...|
Mosquito   691 ------IESKRESSIRPRACLPTPVQEVV------------------QALVSPDDHVRERLFVRL 731

  Fly   823 SCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGK------QFLIDHSKEILRSK 881
            .|..:......:|..||:..:....:|...|.|||.|.:....|:      |||.....|  .:.
Mosquito   732 KCLPKQSNEPSVLLLALERIRAANLLTPGKLFAVLESLIKSDPGRFLPPSVQFLSSVPPE--EAS 794

  Fly   882 DV----KLILTPFINAMSTKAEFSALNDHLHRN---LPSSMVSGLSSTLESGLDRVNWRNNLYFD 939
            .|    :.:|...::.::.:.:.:.:...:.:|   ||::.:...|:.:.|   .::||    ..
Mosquito   795 PVADRFQRLLNLIVHEVTDRRQAAQVRRLMVKNSSILPANFLPHASTVMTS---TISWR----MK 852

  Fly   940 LLKAIRDFTLD 950
            .:..:|:|..|
Mosquito   853 QVPKLREFVHD 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	105/471 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	71/410 (17%)
AgaP_AGAP003926	XP_318379.5	Peptidase_M1	22..414	CDD:279741	91/400 (23%)
		M1_APN_2	30..481	CDD:189008	105/471 (22%)
		ERAP1_C	556..>721	CDD:288671	45/280 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920