DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and AgaP_AGAP004809

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_318000.4	Gene:	AgaP_AGAP004809 / 1278415	VectorBaseID:	AGAP004809	Length:	1020	Species:	Anopheles gambiae

Alignment Length:	1012	Identity:	227/1012 - (22%)
Similarity:	403/1012 - (39%)	Gaps:	182/1012 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQR-TWIYRWASGRK-- 85
            |:.|:|.:.|.:  ...:..|.|.|.|.::..|.|..:.:::..:.:|..: :.:....:|..
Mosquito    71 PIHYDLHLRTEI--HRNERTFTGTVGIQLQVVQATDKLVMHNRGLVMSSAKVSSLPNGVTGAPTL 133

  Fly    86 IGALQIKRIIKKTSLIKIVIELP--LRSGEIYTLNMLFSGNLDRSQQYGYFAGYY-DKTPRVFYS 147
            ||.:|..   ..|:...|....|  |:.| .|.|.:.|.|.|..:....|.:.|. |...|.:.:
Mosquito   134 IGDVQYS---TDTTFEHITFTSPTILQPG-TYLLEVAFQGRLATNDDGFYVSSYVADNGERRYLA 194

  Fly   148 ATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFM-GSP 211
            .|:.|...|...|||:|:|..:..:.:::.|...|.|:||||   :|...:||..:.|||. .:|
Mosquito   195 TTQFESTSARMAFPCYDEPGLKATFTVSITHSLSYKAISNMP---QKTTTDIETDMRTTFFEKTP 256

  Fly   212 PLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPH----------LAEKLAKVPEMTPNLFSKYE 266
            .::|..:.:.:...:...||..      .|:.||:          ...|:.||  :..:|...|:
Mosquito   257 AMSTYLLAFVVSDFQLRLSGAQ------RVYVRPNAFNEATFALEAGVKILKV--LDDHLGIPYD 313

  Fly   267 TLFAYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGEDIV-----DSGQNGLESLQETLAEL 325
            |.    :|       |:|.:.:|.:.. .....|::.|.|..:     .|...|..::..|:|..
Mosquito   314 TY----MP-------KLDQIAIPDFAAGAMENWGLVTYREQALLFNPAVSTYRGKTNVATTIAHE 367

  Fly   326 VARQWNGLLVNLEDSDEEYVRNGIN--YYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKS 388
            .|.||.|.||:.|..:..::..|..  |......||...:.|......:.....:..|..|..:.
Mosquito   368 YAHQWFGNLVSPEWWEYIWLNEGFATLYEFYALDMAYPGQEYWELFNQQVIQYAMGQDGQASTRP 432

  Fly   389 IATDVKESGH-----QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQ 448
            :..:....|.     .::...|...:::|::..|||..:..||:.:....|...|..::|:...|
Mosquito   433 MNWNAATPGEISALFDRVAYDKSGSVLNMMRHVLGDDNWKAGLKAYLTDRALQGAVDEQLYAGLQ 497

  Fly   449 RGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDCWWVP 513
            ........||.||::..:|.:|..:.|:|:|.|:|......|.|:|.|:|......::| .|.:|
Mosquito   498 SAIEGKGVLPNGVTVAQIMRTWTNEAGYPVLNVRRSYDTGDVIISQERFYNDRKVPNTN-IWMIP 561

  Fly   514 VAYIVRNLT----LPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLIS 574
            ..|:.:...    ....:|| ..|.:|  :|.:..||  :|::.|.......||.||.:|.:||:
Mosquito   562 YNYVHQAKADFNEFDDFQWL-ATKAAR--IETTVPAN--EWIVFNKQQVGYYRVNYDEHNWELIT 621

  Fly   575 EALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSI 639
            .||.:::..|..|:|.||:|||..|:.||||...|.|..::||.||.....|..|.:.|....:.
Mosquito   622 NALHENWASIHRLNRAQLIDDAYWLARSGRLDLRVALRFMTYLRNEREYAPWTAANVALTYFNNR 686

  Fly   640 MRMTTGFRIFKLYMQKLIEPAFK-TTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESP 703
            :|.|..:..|.:::..|||..:. .|::::
Mosquito   687 LRGTAEYHNFLIFVDALIEDIYSLLTIDAV----------------------------------- 716

  Fly   704 DTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQA 768
                                        |||.|.....|...:...||.....:||    .:..|
Mosquito   717 ----------------------------SPDDTLLHKYLVQTISTWACSMGYTDCL----MKTAA 749

  Fly   769 AMDQKSSSSIP---EEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWA 830
            .:..::|.:.|   .:|..:..|.|:|:.||..:..:......|:|..||::|::||.|:.....
Mosquito   750 LLKAEASGTGPAVHPDIASVTYCYGMRSALESEFQYLYRKMMNSKNLAERTMLIDSLGCSNNKEF 814

  Fly   831 MQKLLSWALDS-KKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSKDVKLILTPFINAM 894
            ::..|:.||.| ..|.....|.....|:::   .|.|.:..:|...|.|..   ..::..|::.:
Mosquito   815 LKAFLTTALGSGTGVEINYRADERRRVVQA---IYSGGRTGVDALIEFLMD---PALVNEFVSTL 873

  Fly   895 STKAEFSAL-------NDHLHRNLPSSMVSGLSS------------TLESGLDRVNWRNNLYFDL 940
            ||....|||       |:....|..:::::.|.|            |.::.||.||....|.  |
Mosquito   874 STSTLNSALSAIASRTNNVEEMNKLNALITALGSRVNSQTAANLRTTAQANLDWVNGFEGLM--L 936

  Fly   941 LKAIRDF---------------TLDDGPKNSSDSDSN 962
            ...:.:|               |:..||..::.:.|:
Mosquito   937 SNFLAEFAAETLLTTTAAPETTTVTAGPTTTTTTPSS 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	106/481 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	89/401 (22%)
AgaP_AGAP004809	XP_318000.4	Peptidase_M1	64..455	CDD:279741	89/411 (22%)
		M1_APN_2	72..526	CDD:189008	106/481 (22%)
		ERAP1_C	598..923	CDD:288671	88/397 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820