DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and AgaP_AGAP004860

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_314331.4	Gene:	AgaP_AGAP004860 / 1275101	VectorBaseID:	AGAP004860	Length:	915	Species:	Anopheles gambiae

Alignment Length:	1047	Identity:	232/1047 - (22%)
Similarity:	407/1047 - (38%)	Gaps:	281/1047 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLSAKLAESFVKPLRYNLTILT----RLGSEDEQNQFE--GIVSIDIEATQPTRVIYLNSLNITI 70
            ::|.:..:|:..|   |.|:.|    ||.::..:..|:  |.|.|.|...:.|..|.|:|
Mosquito    30 IVSRRAFDSYRLP---NTTVPTHYTLRLDTDIHREIFDYTGNVQIRINVLEATDQIVLHS----- 86

  Fly    71 SRQRTWIYRWASGRKIG-ALQIKRI----IKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQ 130
            ||......:..:|  :| ::.:|..    .|:..::.:...|...:| .|||.:.|:.::.|:.|
Mosquito    87 SRSEITHVQLRNG--VGLSVPVKNFEFDEDKEFLVVNVGTTLQPNTG-TYTLEIDFTNSIARNDQ 148

  Fly   131 YGYFAGYYD--KTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEE 193
            .|::...||  ...|.:...|:.|...|.|.|||:|:|..:|.|:|.:|....|.|.||
Mosquito   149 AGFYRSSYDDENGVRRYLGLTQFESVDARTSFPCYDEPGIKTTYDILIVCGIDYHARSN------ 207

  Fly   194 KPYKEIE----NYVSTTFMGSPPLATQQVMWTLHQLE---KVYSGPAAAGENITVWSRPHLAEKL 251
            .|.:.|:    ....:||..:|.:.|..|.|.:...:   :|.:.|..|   |..||:|.....|
Mosquito   208 APLRGIQLLEGGKKLSTFATTPRMQTYLVAWLVSDFKYEREVLTDPQLA---IASWSKPSSVHLL 269

  Fly   252 AKVPEMTPNLFSKYETLF--AYPLPKGADWGGKVDHVVLPRYTEMYS-----GQGIMVYGEDIVD 309
            :...:.:.......|..|  .|.:       .|:|:|.:.  .|.|:     ..|::.|.|..:.
Mosquito   270 SYSVDASKRFMRAMEEYFDQLYSM-------SKIDNVAIK--DEDYAAGAMENWGLVTYKESAIS 325

  Fly   310 SGQNGLESLQETLAELVARQ--------------WNGLLVNLEDSDEEYVRNGINYYL------S 354
            .|....|..|..:..:|..:              |:.|.:|     |.:.|. ..|||      .
Mosquito   326 YGPEDGEQRQVGVVTIVGHEFTHQFFGNLLAPKWWSYLWLN-----EGFARL-YQYYLGAISHPE 384

  Fly   355 VQVMAMDKEAYNT------------------THLSKTRLDVLYHDSLAKV-KSIATDVKESGHQK 400
            :|:    :|.:.|                  |:.::||      .|:::: .|||.|
Mosquito   385 LQL----RERFVTGPFQTALRADNSLTVRPMTYYTETR------PSISRLFDSIAYD-------- 431

  Fly   401 LRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSS-ASSKELWEEFQRGARRSHQLPTGVSLP 464
               |..|:| .|:..|||::.|.|||:.:.::..... .....|::..::.|:....||..:|:.
Mosquito   432 ---KSACVL-RMMNYALGERTFQKGLRYYLQQNKERGVVEESNLFDSLEQAAKEDAVLPISLSIH 492

  Fly   465 TVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYY-----QKYLDNSSNDCWWVPVAYIVRNLT-- 522
            .:..||..|||.||:.|:||..:.:  .||.||.     ::..:||    ||:|:::...:..
Mosquito   493 EIFGSWSHQPGVPLVKVRRDGNEYL--FTQERYIANTPPEEPFENS----WWIPISFSTPSNNAF 551

  Fly   523 --LPQVEWLGCQKNSRDILELSH-IANPEDWLL-INVDAAVPLRVFYDSYNLQLISEALRQDFTQ 583
              ||.. |:     ..::.|::: |...:|.:: .|..:....||.|:...|:.:.|.:.:|.|.
Mosquito   552 EKLPAF-WM-----PPNVSEVAYTIETVQDEVVSFNPHSTGYYRVEYEESMLRELIERINKDHTG 610

  Fly   584 IPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRI 648
            ....:|.:|:||.|:::.|....|:|.|.:::||..||..:.|..|..||..:||::|  |...:
Mosquito   611 FEPATRARLIDDTLNIAQSRGGNYDVVLQLLNYLQRETDYVPWAVAYENLRHMQSMLR--TNDAV 673

  Fly   649 FKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTE 713
            .:| :::.||......|.......|||                                     |
Mosquito   674 SQL-LERFIEKIASPLLERYGVDHRTG-------------------------------------E 700

  Fly   714 SSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSI 778
            |::..|                      |..|...|||... :.|..|||...::...:|..:.
Mosquito   701 SASVGE----------------------LRTIAIDLACSGS-QSCNDDAQSAVRSLASKKHYTM- 741

  Fly   779 PEEIREIVLCRGI-------RNGLEVHWIMV---RDMFFESENDKERSILLNSLSCT-TEYWAMQ 832
             |:  ..:||.|:       |..|:..:..|   :::    :|...:..||.||||. .:...:|
Mosquito   742 -ED--NALLCHGLQQSNAEQRKALQAQFSQVLSDKNL----DNPSAKQFLLQSLSCLGGDMTKVQ 799

  Fly   833 KLLSWALDSKKVPRTMTASLLSAVLRSPLG------------------YYV-GKQFLIDHSKEIL 878
            ....:.|...:..||.....|...|..||.                  ||. |.:.:.:.::.:.
Mosquito   800 SFAKYLLALSESDRTKALHRLLVELNVPLAEIVQSLQSELSQRRSNSVYYKHGPKLIFEIARYVT 864

  Fly   879 RSKDVKLILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESGLD-RVNW--------RN 934
            ...||:|:                      .::.||..|.::|.:|..:: .:||        :|
Mosquito   865 DPSDVQLL----------------------SSVASSYDSWVASEIEQQVNANLNWVEQNVEPLKN 907

  Fly   935 NL--YFD 939
            .|  |||
Mosquito   908 ALTRYFD 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	120/518 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	82/409 (20%)
AgaP_AGAP004860	XP_314331.4	Peptidase_M1	40..433	CDD:279741	100/448 (22%)
		M1_APN_2	48..505	CDD:189008	118/510 (23%)
		ERAP1_C	580..>680	CDD:288671	30/102 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920