DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and AgaP_AGAP003695

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_313478.5	Gene:	AgaP_AGAP003695 / 1274368	VectorBaseID:	AGAP003695	Length:	920	Species:	Anopheles gambiae

Alignment Length:	955	Identity:	209/955 - (21%)
Similarity:	385/955 - (40%)	Gaps:	202/955 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KPLRYNLTI-LTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKI 86
            :||.|:|.: :|    :...:.:.|.|.|.|:.|....:..|||:::.|:.:...:.| .:|.|:
Mosquito    46 EPLYYDLYLDMT----DANFSNYAGSVDITIKYTGNGSIFSLNSVDLAINEETLRVER-MNGTKV 105

  Fly    87 GALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTPRV------- 144
             .|:...:.::...:.......|.||..|.:::.|:|.:    :...|.|.|..:.||
Mosquito   106 -PLESFTVSRQFEQLYFNCTEKLESGASYNVHLEFNGTI----KTDIFKGVYRSSYRVDGEIKYL 165

  Fly   145 ---FYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTT 206
               |::||     ||.|||||:|:|..:..:|:.:.|...:.||||||.:..   ..|:.|..||
Mosquito   166 ATTFFAAT-----YARTVFPCYDEPGHKARFNVKIRHRSHHTALSNMPVIRS---TMIDGYSETT 222

  Fly   207 FMGSPPLATQQV------MWTLHQLEKVYSGPAAAGE-NITVWSRPHLAEKLAKVPEMTPNLFSK 264
            |..:|.::|..|      |.||..:::::...|...: |.||::. ..|.:..:..|   |.|.:
Mosquito   223 FDTTPLMSTYLVAFVVSEMKTLSSVDELFRVYAPENKVNYTVYAH-DFAVRAVRALE---NHFGR 283

  Fly   265 YETLFAYPLPKGADWGGKVDHVVLPRYT-EMYSGQGIMVYGED--IVDSGQNGLESLQETLAELV 326
            ...:            .|:|.|.:|.:. ......|::.:.||  |....:......::.:|.::
Mosquito   284 QNQM------------RKIDLVGIPDFAMGAMENWGMITFREDYLIYQDEEETTALAKQKIASVI 336

  Fly   327 ARQ--------------WNGLLVNLEDSDEEYVRNGINYYLSVQV----MAMDKEAYNTTH--LS 371
            ..:              |..:.:|      |...|...||::.|:    ...|:...:..|  ||
Mosquito   337 THELVHMWFGNEVTPEWWTYVWLN------EGFANFFEYYITSQLEPAWRLWDQFILDNVHWALS 395

  Fly   372 KTRLDVLYHDSLAKVKSIATD--VKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYA 434
            |..     |.|:..:...|||  |....:..:..:|...:|.|::..:|...|.:.:.::.:..:
Mosquito   396 KDS-----HSSVRPMNYYATDPAVLNGLYDYVVYQKSASVIRMIQNVIGFDTFQQAINDYLRSRS 455

  Fly   435 NSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQ 499
            ..:...:.|:...::  .|:..||..|.:  :.|||...||:|::||..|...:.:|.:|.|::.
Mosquito   456 YLTTRPQYLYTSIEK--FRTVDLPASVEV--IFESWANTPGYPVVTVSIDRTTRTLTASQKRFWM 516

  Fly   500 -KYLDN-SSNDCWWVPVAYIVRNLTLPQVE------WLGCQKNSRDI-LELSHIANPEDWLLINV 555
             ..||. ..|..:::||.|.....|....|      ||..|..:..: ||..     .:|:::|.
Mosquito   517 PNELDTPPQNMLFYIPVNYGSNVPTSTDFEDTTPTFWLTPQDPTATVSLEAG-----VEWVVVNK 576

  Fly   556 DAAVPLRVFYDSYNLQLISEALRQD--FTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLS 618
            ......||.||..:...:.|.|..|  ..|:|.::|.|||||..:|:.:|.:.|:|.|:::.||.
Mosquito   577 QQTGYYRVNYDDESWHKLIEVLNSDQFEDQLPVINRAQLVDDVANLARAGEVGYDVALSLMQYLE 641

  Fly   619 NETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTK 683
            .||..:.|.||...|:.|..:......:..|:.|:..|....|    |.::.
Mosquito   642 RETEYIPWATAYNALQHLDRMFSSHKEYNRFENYVGMLASHVF----NEMNL------------- 689

  Fly   684 SPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYR 748
                                                       .||....:....|.|:     .
Mosquito   690 -------------------------------------------FDTESHLNRLHRDKSV-----Y 706

  Fly   749 LACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIR--------NGLEV---HWIMV 802
            |||.|.::.||..|.:..:.|:.:: :.:||:|::..|.|...:        .|||:   :|:..
Mosquito   707 LACYFGVEACLDAATKIIEEALAEE-TLNIPKELQNAVFCALHKYDLLVEGDYGLEIFQKYWLAT 770

  Fly   803 RDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPL-GYYVG 866
            ..  ::...||    .:|:|.|:... ||.:.....::..:....:|.|:.:.:|.|.: |....
Mosquito   771 DQ--YQPLMDK----FINALGCSRNL-AMNEFYLQMIEINETALPITVSMKNNILNSMIKGGPAT 828

  Fly   867 KQFLIDHSKEILRSKDVKLILTPFINAMSTKAEFSAL---NDHLH 908
            :.....:.||::.:....|      |..|.:|...||   .::||
Mosquito   829 RSAAFRYLKELIHTHQTSL------NPSSMQAATRALAQAEENLH 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	109/494 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	78/375 (21%)
AgaP_AGAP003695	XP_313478.5	Peptidase_M1	40..427	CDD:279741	95/425 (22%)
		M1_APN_2	50..494	CDD:189008	108/492 (22%)
		ERAP1_C	572..>838	CDD:288671	68/338 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920