DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and AgaP_AGAP003077

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_003436384.1	Gene:	AgaP_AGAP003077 / 1273751	VectorBaseID:	AGAP003077	Length:	1054	Species:	Anopheles gambiae

Alignment Length:	988	Identity:	231/988 - (23%)
Similarity:	402/988 - (40%)	Gaps:	200/988 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNS--LNITISRQRTWIYRWASGR 84
            ::|:.|.|.:...|    ::..|.|.|.|::..::.|..|.|:|  |:||.:..||      .|.
Mosquito   177 IRPVHYELWLQPDL----QRETFSGRVGIELNVSESTNYIVLHSKKLSITETVLRT------LGT 231

  Fly    85 KIGALQIKRIIKKTSLIKIVIELPLRSGEI----YTLNMLFSGNL-DRSQQYGYFAGYYDKTP-R 143
            ....:.|.|..:.......|||   ..|||    |.|::.|:|:| ||...: |.:.|.|||. |
Mosquito   232 GAEEVTIARAYELPEHEYWVIE---TQGEIGAGAYRLSVQFNGSLADRIIGF-YSSKYLDKTTNR 292

  Fly   144 VFYSAT-RLEPDYAHTVFPCFDDPRFRTPYNITLVHDR--KYVALSNMPPVEEKPYKEIENYVST 205
            ....|| :.||.:|...|||||:|..:..|.|.:||..  .|.|||||...|....|......:|
Mosquito   293 TRTIATSKFEPTFARQAFPCFDEPHLKAEYTIHMVHPSGDGYAALSNMNVKETVADKPSAGLSTT 357

  Fly   206 TFMGSPPLATQQVMWT----LHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYE 266
            ||..|..::|..|::.    ||| |.:......:...:.|::.|...|..|........:...|.
Mosquito   358 TFERSVSMSTYLVVFIVSDFLHQ-EVLIVPEHGSSFPLRVYATPFQQENTAYALATARTIIEYYV 421

  Fly   267 TLF--AYPLPKGADWGGKVDHVVLPRYTEMYSGQ----GIMVYGE-DIVDSGQNGLESLQETLAE 324
            ..|  |||||       |:|...:|   :..||.    |::.|.| .|:.:.:....:.::.:|.
Mosquito   422 KYFGIAYPLP-------KLDMAAIP---DFVSGAMETWGLVTYRETSILYNSETSSTANKQRVAG 476

  Fly   325 LVARQ----WNGLLVNLEDSDEEYVRNGINYYLSVQVMAMD--------KEAYNTTHLSKTRLDV 377
            ::|.:    |.|.||.::..:|.::..|...|  ::...||        :|.:....|.    .|
Mosquito   477 VIAHELAHMWFGNLVTMKWWNELWLNEGFASY--IEYKGMDAAHPDWGIEEQFIIDDLH----GV 535

  Fly   378 LYHDSLAKVKSIATDVKESGH-----QKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSS 437
            |..|:......|...|:....     ..:...|...:|.||:..:...:|.:|::.:.::.|.::
Mosquito   536 LNLDATLGSHPIVMSVENPNQITEIFDTITYSKGASVIRMLEDFVTPPVFQQGVKRYLEKLAYAN 600

  Fly   438 ASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYL 502
            :.|::|..|..       :|...||:..||:::.:|.|.|::|| .::|.|.| :.|.|:   ..
Mosquito   601 SVSEDLMRELD-------ELVPDVSVTDVMDTFTRQKGLPVVTV-AENALQYV-LRQQRF---LA 653

  Fly   503 DNSSNDC--------WWVPVAYIVRN----LTLPQVEWLGCQKNSRDILELSHIANP--EDWLLI 553
            |..:|:.        |::|:.|:...    ...|:..|.....:..:::    |..|  ..|:.:
Mosquito   654 DQDANETEESPYGYRWYIPITYLASTDDPATAAPRRIWFPNDASRPELV----IDKPAGSSWIKL 714

  Fly   554 NVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLS 618
            |.......||.|.....|...||||::........|..|::||.:|:.:..|.||..|.:..|||
Mosquito   715 NYRQIGYYRVNYPIAMWQQFGEALRKEVNTFTIGDRTGLLNDAFALADASLLAYNHALELTRYLS 779

  Fly   619 NETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTK 683
            .||..:.|......|:.:::::.....:.....|.|.|::.|.|:          .|.|:|
Mosquito   780 GETEYVPWSAIASKLKNIRNLLYNYQSYDDITTYTQTLVDAAVKS----------VGWEVP---- 830

  Fly   684 SPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYR 748
                                  ||....|....||                           :..
Mosquito   831 ----------------------AEGGHMTNLLRTT---------------------------ILD 846

  Fly   749 LACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEV-HWIMVRDMFFESEND 812
            |||.|....||.:|.::|:..::  :.:.|..::|.:|...||::|:.| .|..|.:.|.:..:.
Mosquito   847 LACSFGHPACLEEASKQFRGWLN--AGAVIHPDLRSVVYTYGIQSGVTVADWDKVLERFRQENDA 909

  Fly   813 KERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYV-----GKQFLID 872
            .|::.|:.:|:...:...|::.|..:.|:..|   .|...||.:      .|:     |:|...:
Mosquito   910 NEKTKLMVALASYPDQRTMRRFLDLSWDTALV---RTQDQLSCI------QYIAANRAGEQAAWE 965

  Fly   873 HSKE-----ILR----SKDVKLILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSST-----L 923
            |.:|     :.|    .:::..::.......:|:|..:.|.|...| .|.   ||..:|     |
Mosquito   966 HVRENWPRLVARFGIGERNLGRMIPSVTGRFTTQARLTELEDFFAR-YPE---SGAGATARRQAL 1026

  Fly   924 ESGLDRVNW--RN 934
            |:..:.::|  ||
Mosquito  1027 ENIQNNISWLERN 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	126/490 (26%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	83/397 (21%)
AgaP_AGAP003077	XP_003436384.1	Peptidase_M1	172..569	CDD:279741	110/422 (26%)
		M1_APN_2	180..633	CDD:189008	126/490 (26%)
		ERAP1_C	712..1028	CDD:288671	82/393 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920