DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and AgaP_AGAP000131

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_311016.5	Gene:	AgaP_AGAP000131 / 1272138	VectorBaseID:	AGAP000131	Length:	1080	Species:	Anopheles gambiae

Alignment Length:	1020	Identity:	195/1020 - (19%)
Similarity:	378/1020 - (37%)	Gaps:	213/1020 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQP-TRVIYLNSLNITISRQRTWIYR------ 79
            |.|..|.|.|.......|....:.|||.:.:.:.:| .:.|.||..|:.|..:...:.:
Mosquito   149 VIPKHYRLFIHPVFNETDHPFSYTGIVWVTVTSKKPNNKRIELNVKNLKIRLENVTVLKSIRLTN 213

  Fly    80 --------WASGRK----------------------------------IGALQIKRIIKKTSLIK 102
                    |....:                                  ...::|..|....|..|
Mosquito   214 NDFDEDLDWDLSEEDLYSLPRLNRRRRRRRQADLPSKFYHHPVFPADDFVTIKILDIEFDESNEK 278

  Fly   103 IVIEL--PLRSGEIYTLNMLFSGNLDRSQQYGYFAGYYDKTP-RVFYSATRLEPDYAHTVFPCFD 164
            ::|.|  .::....|.:.:.|.||:...:.. |:..|.|..| ...::||.|||:.|..::||.|
Mosquito   279 MIIFLGTEMKKDIYYIVKVNFFGNMTNDKGL-YYTHYEDDGPDHRHFAATVLEPNNARRLYPCMD 342

  Fly   165 DPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQL--EK 227
            |..||:|:.:.:.........|:|.....:| .|..:.|..|:..:..:...::.:.:..:  |:
Mosquito   343 DHNFRSPFELNIARKSDMNTASSMNLEMSEP-METGDIVVDTYNTTDMVRASEIGFVVTDMVPER 406

  Fly   228 VYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYT 292
            .   ...|..::..::|....|.:.....:.......||.....|.|...     :.:|.:|...
Mosquito   407 Y---RITARVSLLAFTRTRYDENIKNATSVFSRALQIYEQYLGVPFPYEV-----IRYVTIPNID 463

  Fly   293 -EMYSGQGIMVYGEDIVDSGQNGL-----------ESLQETLAELVARQWNGLLVNLEDSDEEYV 345
             :.|.      ..|.:|.|.:..|           :|:...:|..:|:.:...|.:.::.:..::
Mosquito   464 HQTYE------IKEGMVLSSEKRLIKTADYFPPLDKSINREVANELAKLFIHKLADYKNKETYWL 522

  Fly   346 RNGINYYLSVQVMAMDKEAYNTT---HLSKTRLDVLYHDSLAKVKSI---ATDVKESGHQKLRKK 404
            ...:..||....:.....|.:||   .|.:.||..:..:...|..::   ....:|..|.:|.|.
Mosquito   523 HESLPLYLEALALRNMTTANSTTLDDFLLEGRLRSMREEMNTKTSALNIFTNHWEEDTHFELVKY 587

  Fly   405 KMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMES 469
            |...::.|:...||.:.|.:.::|:| ||...| .|.::.:....|:........|| ..:.:.|
Mosquito   588 KGLSVLRMMNYTLGQRTFDRFVREYF-RYRMES-ESIDVIDILNGGSGEGASRTDGV-FHSFLYS 649

  Fly   470 WMKQPGFPLLTVQRDDAKQIVTITQSRYYQ------KYLDNSSNDCWWVPVAYI---VRNLTLPQ 525
            |.....:|::.::|::|        :.||:      .:.:..:...|.|||.:|   .:.|.:.:
Mosquito   650 WSSLEKYPIINIRRNNA--------TGYYELRQIPLPFEEEPAEQLWTVPVTFINDTNQRLFVEK 706

  Fly   526 VEWLGCQKNSRDILELSHIAN-PEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSR 589
            |.||..::|...:......:| ...|:::|.......||.|:..:...::..|..:|..:|..:.
Mosquito   707 VRWLTDEENLLTVQSDCSTSNGSASWIIVNPSGIGYYRVNYEPAHWIKLAHVLYGNFHYLPYTTL 771

  Fly   590 IQLVDDALSLSWSGRLPYNVTLNVISYLS-NETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYM 653
            ..:|||||:|:..|.|.|:|..||:|:|. |......|:.||.|||.:.........||..:.::
Mosquito   772 AIIVDDALNLARLGLLNYSVAFNVVSFLKHNNEHYQPWKLALSNLEFVYHATEDLPSFRHVERFL 836

  Fly   654 QKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTT 718
            :.||...::        :.:.|:|
Mosquito   837 EYLILSKYE--------EIQRGNE----------------------------------------- 852

  Fly   719 ESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIR 783
                            |...:..:..::.:.||:..:..|:...:..|||.:..::.|  |.|.|
Mosquito   853 ----------------TAHYNPLIKELIVQWACKLGVTSCIEQHKALFQAILRNQTVS--PFEQR 899

  Fly   784 E----IVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKV 844
            |    .:||..|:......|..|...:.|:.:...:.||:.||.||.|...:::.|...    |.
Mosquito   900 EERLHRILCTTIKYSGLAEWKRVEQQYRETTDINYQRILIKSLGCTREISMIKRYLGLL----KH 960

  Fly   845 P--RTMTASLLSAVLRSPLGYYVGKQFLIDHSKEI---LRSKDVKLILTPFINAMSTKAEFSALN 904
            |  |..:..:|:|:..:.:.......||.:...::   |..:|:.::|    .::|...||....
Mosquito   961 PHFRMYSKEILTAISENKVALKYTLDFLFNEWLDVRLYLTLQDISILL----RSISNMNEFKMYE 1021

  Fly   905 DHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLLKAIRDFTL 949
            ....|         .|.|.:: :|:         ::||.:||..:
Mosquito  1022 QIFFR---------YSYTFQT-MDK---------EILKRMRDIII 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	95/523 (18%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	76/387 (20%)
AgaP_AGAP000131	XP_311016.5	GluZincin	153..614	CDD:301352	86/477 (18%)
AgaP_AGAP000131	XP_311016.5	ERAP1_C	733..1025	CDD:288671	73/366 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810