DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and AgaP_AGAP013001

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_003436574.1	Gene:	AgaP_AGAP013001 / 11176075	VectorBaseID:	AGAP013001	Length:	1071	Species:	Anopheles gambiae

Alignment Length:	1014	Identity:	229/1014 - (22%)
Similarity:	406/1014 - (40%)	Gaps:	204/1014 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTR--VIYLNSLNI-TISRQRTWIYRWASG 83
            ::|:.|::.::..|  .::...|.|.|.:.:...:...  .:::.:||| :.|.:|      ::|
Mosquito   163 IEPVAYDIRLIPWL--VEDNFTFLGTVEVLVNVLEDCSNVTLHVAALNIHSASVER------STG 219

  Fly    84 R--------------KIGALQIKRIIK--------KTSLIKIVIELPLRSGEIYTLNMLFSGNLD 126
            |              ..||..::.:::        ......::::.|||.||.|.:.:.:.|.|:
Mosquito   220 RGEEQHSEEATADESSEGAPLVREMVEIDHNLTVASKQFYVLMLKTPLRRGEQYVVRLRYDGVLN 284

  Fly   127 RSQQYGYFAGYYDKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPV 191
            ...|..|.:.|.......:.:.|:.:|..|...|||||:|..:..:||::...|..::|||||.:
Mosquito   285 DYLQGFYRSSYTANNETRWIATTQFQPTDARRAFPCFDEPALKARFNISIARTRDMISLSNMPRL 349

  Fly   192 EEKPYK----------EIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPH 246
              :.|:          |::.||...:..|.|::|..|.:.:.....:.||      |..||:|..
Mosquito   350 --RSYEARTIDIFSEPELQGYVWDVYQQSVPMSTYLVAFVVCDYLNLTSG------NFAVWARAD 406

  Fly   247 LAEKLAKVPEMTPNLFSKYETLF--AYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGED-- 306
            ..........:.|.|....|..|  .||||       |||.:.||.::. .....|::.|.|.
Mosquito   407 AIGSARYALSVGPKLLKFLEDFFHIEYPLP-------KVDMIALPDFSAGAMENWGLITYRETAM 464

  Fly   307 IVDSGQNGLESLQETL---AELVARQWNGLLVNLEDSDEEYVRNGI-NY--YLSVQVM-----AM 360
            :.:...:.:.:.|..:   |..:|.||.|.||......:.::..|. :|  ||.|..:     :|
Mosquito   465 LYEENVSAISNKQHVITVVAHELAHQWFGNLVTPSWWTDLWLNEGFASYMEYLGVDAVEPAWKSM 529

  Fly   361 DKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDV--KESGHQ---KLRKKKMCLLIHMLKVALGDK 420
            ::...|..|      :|...|:|:....|:.:|  .|..|:   |:...|...:|.|:...|..:
Mosquito   530 EQFVVNELH------NVFSLDALSSSHQISVEVHNPEEIHEIFDKISYGKGATIIRMMDHFLTTE 588

  Fly   421 LFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDD 485
            :|.:||..:.......|||..:|||.....|||........|:..:|::|..|.|||::.||||.
Mosquito   589 VFKRGLTNYLNDKQYQSASQDDLWEYLTNEARRGGIFDEHTSVKEIMDTWTLQTGFPVVFVQRDY 653

  Fly   486 AKQIVTITQSRY-YQKYLD-------NSSNDCWWVPVAYIVR-----NLTLPQVEWLGCQK---- 533
            ....:...|.|: :...|:       :|....||:|:.|...     ..|.|.: |:..::
Mosquito   654 ESDSIEFRQERFSFANALNGTDGVARHSERFLWWIPITYTTLGDSNFQQTKPSI-WMKAEEALVI 717

  Fly   534 NSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEAL--RQDFTQIPELSRIQLVDDA 596
            |:.||  .||     ||:::||......||.||..|.|:|...|  |..:..|...:|.||:|||
Mosquito   718 NNHDI--PSH-----DWMIVNVQQTGYYRVNYDERNWQMIVRHLQDRNKYKTIAASNRAQLIDDA 775

  Fly   597 LSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAF 661
            |:|:.:|.|.|.|.|||..||.:||..:.|:.|:..|..:.|:...|..:.:||.|...|:|..:
Mosquito   776 LNLARAGYLDYGVALNVTRYLVHETDYVPWKAAIAALNYIDSMFIRTRNYGLFKKYSMDLLENIY 840

  Fly   662 KTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTES 726
            :          ..|.|                          |..:||..|.....:
Mosquito   841 R----------EVGFE--------------------------DHRDSPLLTVYKRIS-------- 861

  Fly   727 SDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKS---SSSIPEEIREIVLC 788
                               :.:..|....|:|:....:::...|.|.:   ::.|...::..|.|
Mosquito   862 -------------------VLKAVCHLGNKDCVNHCLRKYYEWMHQPNPDINNPISPNLKSTVYC 907

  Fly   789 RGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTA--- 850
            ..|:.|.|..|....:.|.::....|:.|||:::.|:...|.:.:.|..|:..:...|...|
Mosquito   908 TAIKYGDETEWDFAWERFQKATVASEKEILLSAMGCSRVPWILARYLENAMSDEYGIRKQDAFRV 972

  Fly   851 --SLLSAVLRSPLGY-YVGKQFLIDHSKEILRSKDVKLILTPFINAMSTKAEFSALNDHLHRNLP 912
              |:...|:..|:.: |:...:....|.......::.:||.......:|::|...|.:....:|.
Mosquito   973 FISVADNVIGQPIAFDYMRNNWAKMKSYFGASMSNLNIILKYCTKRFNTESELLELKEFAEIHLK 1037

  Fly   913 SSMVSGLSSTLESGLD---------------RVNWRNNL 936
            .|     ..|::..::               .|||.|.:
Mosquito  1038 DS-----GRTIQQAIEWTESNIAWLNRNAQPIVNWLNEV 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	117/507 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	83/403 (21%)
AgaP_AGAP013001	XP_003436574.1	Peptidase_M1	158..574	CDD:279741	97/439 (22%)
		M1_APN_2	168..645	CDD:189008	117/505 (23%)
		ERAP1_C	729..1048	CDD:288671	83/386 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920