DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and AgaP_AGAP013393

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_003436571.1	Gene:	AgaP_AGAP013393 / 11176044	VectorBaseID:	AGAP013393	Length:	914	Species:	Anopheles gambiae

Alignment Length:	960	Identity:	191/960 - (19%)
Similarity:	357/960 - (37%)	Gaps:	218/960 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQ--FEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGR 84
            |.|..|::.|...|..|..:.|  |:|...|.: :||..     |.:.|.:...|..|..|:..|
Mosquito    51 VWPTHYDIEIKPYLEQEGNKAQFTFDGSAKITV-STQKQ-----NVMQIKLHMARMDITAWSVTR 109

  Fly    85 KIGALQIKRI----IKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYY-DKTPRV 144
            |.....|..:    .::|.::.:.:...|::...|.|:..:.||:| ...:|::..|| :...:|
Mosquito   110 KSDNTIIPTLPQTYDQETQILTLPLSSALQANVEYVLSFTYVGNMD-DDMHGFYRSYYWEDGVKV 173

  Fly   145 FYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMG 209
            :..:|:.:..:|...|||||:|||:..:.:.:.|..:|...|| ..:......|:...: |||..
Mosquito   174 WMGSTQFQQTHARRAFPCFDEPRFKATFQLKINHKTQYNVYSN-TAIVGTAVAEVGRSL-TTFGV 236

  Fly   210 SPPLATQQVMWTL--HQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYP 272
            :|.:::..:.:.:  :|:..        .:.:.:.:||....:.....::...|....|....||
Mosquito   237 TPSMSSYLIAFIVAPYQIND--------RDGMGILARPQAQNQTQYSLDVGIKLLKALEEWIDYP 293

  Fly   273 LPKGADWGGKVDHVVLPRYTEMY------------SGQGIMVYGEDIVDSGQNGLESLQE----- 320
                        :..:...|.||            ...|::.|.|..:....:...|:|:
Mosquito   294 ------------YASVAGMTRMYMAAVPDFSAGAMENWGLLTYRETNILYRSDDSTSMQQHRIAA 346

  Fly   321 TLAELVARQWNGLLVNLEDSDEEYVRNGI-NYYLSVQVMAMDKEAYNTTHLSKTRLDVLYHDSLA 384
            .::..:|.||.|.||..|..|..::..|. .||           .|..|.|.:|..|:.:...:.
Mosquito   347 VISHEIAHQWFGDLVTCEWWDVTWLNEGFARYY-----------QYYGTALVETEWDLDHQFVVE 400

  Fly   385 KVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQR 449
            ::::..:.:.::    :...|..:::.|::..|..:.|...|:.:.|..|..:...::|:....|
Mosquito   401 QLQAQTSGIFDN----ISYNKGAVMLRMMEHYLTTETFKTALRAYIKDRAFKTTRPEDLFNALNR 461

  Fly   450 ---GARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDCWW 511
               .||            :.||.|..|||:||:||...|..  .||||.|:.....|::....|.
Mosquito   462 YDPNAR------------SYMEPWTVQPGYPLVTVTSHDTG--FTITQKRFLVNEPDHNEQTAWP 512

  Fly   512 VPVAYIVR----NLTLP--------QVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVF 564
            :|:.:..:    ::|.|        ::...|              |:..::.::|.......||.
Mosquito   513 LPITFATKASEFSITRPAFYTGMTFEIPMQG--------------ASDVEYFILNNQQVGYYRVN 563

  Fly   565 YDSYNLQLISEALRQD-FTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWET 628
            ||:.....||:||..: |..|..|:|.|:|||..:|:....:||...|.::.||..||....|..
Mosquito   564 YDAILWGKISKALHSEGFGGIHVLNRAQIVDDLFNLARGDVVPYGTALEILEYLKEETEYAPWLA 628

  Fly   629 ALLNLEKLQSIMRMTTGFRIF----KLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTE 689
            |:..|..|..        ||.    ||:...::: .|....:.:..:|.|.:|..|.|
Mosquito   629 AVNGLTTLSR--------RIHADDEKLFTAHILD-IFSKAYDIVKFQAPTATERRIFT------- 677

  Fly   690 SSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFE 754
                                                               .:...:.:.||.:.
Mosquito   678 ---------------------------------------------------YMRQNVLQWACNYG 691

  Fly   755 IKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILL 819
            .:||...|...|. ...|..|..:..::|::|.|.|||.|....:..:.:.:..:....|:.::|
Mosquito   692 HEECSKAAVAEFH-RYHQNPSVKVHPDLRQVVYCEGIRKGSTEEFEFLWNQYLTTNVATEQILIL 755

  Fly   820 NSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRS-----PLGYYVGKQFLIDHSKEILR 879
            ..|.|              :.|.::...|...:.|..:||     ...|.:...:.:.|....|:
Mosquito   756 QGLGC--------------VSSSELITDMLNGIASPHVRSQDKNNAFTYVINNPYTLPHVSRYLQ 806

  Fly   880 SKDVKLILTPFINAMSTKAEF----SALNDHLHRNLPSSMVSGLSSTLES 925
            ....        |..::...:    ||.|:.|.|....|....:|:.:||
Mosquito   807 QNHA--------NWAASHGSYTNVASAFNNVLARLKSDSERDAISAFIES 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	96/481 (20%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	76/389 (20%)
AgaP_AGAP013393	XP_003436571.1	Peptidase_M1	46..418	CDD:279741	81/410 (20%)
		M1_APN_2	54..480	CDD:189008	96/481 (20%)
		ERAP1_C	550..867	CDD:288671	76/389 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920