DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and AgaP_AGAP013146

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_003436568.1	Gene:	AgaP_AGAP013146 / 11175863	VectorBaseID:	AGAP013146	Length:	941	Species:	Anopheles gambiae

Alignment Length:	1036	Identity:	206/1036 - (19%)
Similarity:	370/1036 - (35%)	Gaps:	248/1036 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CTLLSAKLAESF----------------VKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPT 58
            ||.|.::|.:..                |.|..|::.|......|.|:..|    :.|...|...
Mosquito    25 CTPLHSQLFDEVDLQSRAQLEEYRLNDDVWPTHYDIEIKPYFEPEPEKEAF----TFDATTTIAV 85

  Fly    59 RVIYLNSLNITISRQRTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELPLRSGEI-----YTLN 118
            .|:..|...|.:.:....:..|...||..::.:.::.:..:....:..|.|:..|:     |.:.
Mosquito    86 TVLKDNVTQIKLHKAHMNVTDWRVMRKSNSMPVGKVNETYNEETQIWTLNLKPSELVKNVEYNIV 150

  Fly   119 MLFSGNLDRSQQYGYFAGYYD-KTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRK- 181
            :.:.|.::.... |::..|:. ...:|:..:|:.|...|...|||||:||::|.:.:.|  |.|
Mosquito   151 VNYVGRMEEDMG-GFYRSYFKVNGKQVWLGSTQFEQTEARRAFPCFDEPRYKTTFTLKL--DYKP 212

  Fly   182 --YVALSNMPPVEEKPYKEIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSR 244
              |...:|.|.|...|.:  .|....||..:|.::|..:.:.:...|      ..:.:.:.|.:|
Mosquito   213 DEYNVYANTPIVNSVPTR--YNRTLATFGITPKMSTYLLAFIVAPYE------LKSSDVMGVLAR 269

  Fly   245 PHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVV--LPRYTEMY------------ 295
            |....:            :.|.......|.|..  |..||:..  :|..|.||
Mosquito   270 PEALNQ------------TDYSVQEGLKLLKAL--GNWVDYPFNSVPEITRMYMAAIPDFAAGAM 320

  Fly   296 SGQGIMVYGEDIVDSGQNGLESL-QETLAELV----ARQWNGLLVNLEDSDEEYVRNGINYY--- 352
            ...|::.|.|..:...|....|: |:.:|.::    |.||.|.||..|..|..::..|...|
Mosquito   321 ENWGLITYRESSLLYVQEDATSMQQQRIASIISHELAHQWFGNLVTCEWWDVTWLNEGFATYFEY 385

  Fly   353 -----------LSVQVM------AMDKEAYNTTH-LSKTRLDVLYHDSLAKVKSIATDVKESGHQ 399
                       |.||.:      ||..:....|| ::.|    :|..:.|.....|....:.|
Mosquito   386 FGTALVEPLWELDVQFVVEKLQAAMQTDGSLATHPMTHT----VYTQTQAAAMFDAISYNKGG-- 444

  Fly   400 KLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEF-QRGARRSHQLPTGVSL 463
                    :::.||:..|....|...::|:.|....::|..::|:... :|.|..|
Mosquito   445 --------VVLRMLEHYLSPDAFQAAIREYVKDRQFATARPEQLFTVLDKRNANAS--------- 492

  Fly   464 PTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNSSNDCWWVPVAYIVR----NLTLP 524
             ..|:.|..||||||:||....  ..|.:||.|:.....|......|.:|:.:..:    ..|.|
Mosquito   493 -AFMKPWTTQPGFPLVTVTSHG--NGVKLTQKRFIANGTDAEEKLLWPLPITFATKESEFESTTP 554

  Fly   525 QVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALR-QDFTQIPELS 588
            .:  :..:.::..:..:|.:|    :.::|.......||.||....:.|..||| :.|..|..|:
Mosquito   555 TI--VSSESHNITLANMSDVA----YFILNNQQVGYYRVNYDEALWEKIGAALRSRAFGGIHVLN 613

  Fly   589 RIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGF------- 646
            |.|:|||.|:|:.:..|.|...|:::|||..|.....|..|.             .||
Mosquito   614 RAQIVDDLLNLAKADVLGYGKVLDLLSYLKQEMEYAPWLAAF-------------NGFASLAPRI 665

  Fly   647 -----RIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTA 706
                 ::|..|:..::...::.                :..::|
Mosquito   666 HPDDEKLFTQYLMDILTDVYEY----------------VKFQAP--------------------- 693

  Fly   707 ESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRL----ACQFEIKECLTDAQQRFQ 767
                                         |:.|..|...|.||    .|::...:|...|.:.|:
Mosquito   694 -----------------------------TQYDRRLHTYLRRLVLDWTCRYGHDDCSKSAVKEFE 729

  Fly   768 AAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQ 832
            ...........| ::|::|.|.|:|.|....:..:.::|..:....|:.:.|..:||..:...:.
Mosquito   730 RFRTYPGVKVHP-DLRQVVYCEGVRKGSSEQFDFLLNIFLTTNVATEQQLTLFGMSCAPKEETVN 793

  Fly   833 KLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRS----KDVKLILTPF--- 890
            |.:: .:.|..|.....||.||.:|.:.........:|:.:|.....:    :.|.:.|...
Mosquito   794 KFMN-LVSSADVRSQDKASALSMLLNNQHALEPAASYLVQNSARWAEAHGGYRHVAMALGGILGR 857

  Fly   891 INAMSTKAEF----SALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLLKAIRDF 947
            :|.:|.:...    .|..|.|.|.        ....:.|||.:.::..|...:..:.||.|
Mosquito   858 VNDVSVRTSIEQFAEASKDVLGRE--------AYELIASGLIQFDYNQNFTMNHREEIRGF 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	104/501 (21%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	76/405 (19%)
AgaP_AGAP013146	XP_003436568.1	Peptidase_M1	48..443	CDD:279741	89/427 (21%)
		M1_APN_2	56..505	CDD:189008	104/501 (21%)
		ERAP1_C	575..879	CDD:288671	71/384 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020