DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and AgaP_AGAP013150

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_003436699.1	Gene:	AgaP_AGAP013150 / 11175624	VectorBaseID:	AGAP013150	Length:	939	Species:	Anopheles gambiae

Alignment Length:	990	Identity:	203/990 - (20%)
Similarity:	373/990 - (37%)	Gaps:	194/990 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SFVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQ----------- 73
            |::.|..|.|.:.|::.:.:  ..:.|.|.|.::..|..:.||::...:.|:..
Mosquito    54 SYIVPTHYKLYLETQVHTGN--RSYSGSVDIHLDIRQQAKTIYVHQRGLRITSNELYASNPNTNL 116

  Fly    74 ---RTWIYRWASGRKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFA 135
               .|..|...:.|:.....|:|.:...|               |.|::.|.|.|.......|.:
Mosquito   117 TFLETLRYTEDAEREFAVFAIRRALAPAS---------------YVLHLDFEGELRVDDDGFYLS 166

  Fly   136 GYYDKT-PRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEI 199
            .|.|.. .|.:.::|:.:...|...|||.|:|..:....:.:.|...|.|:||||...|.  .::
Mosquito   167 SYLDANGTRKYVASTQFQAISARAAFPCLDEPALKATVELGIKHHPSYKAVSNMPIFAEA--GDL 229

  Fly   200 ENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSK 264
            :..|.|.|..:|.::...:.:.:...  :|:...||.:.  |::||:...:.....|....:...
Mosquito   230 DGNVVTYFETTPRMSIYLLAFLVSDF--LYTENEAAAQR--VYARPNAINQTLYALEAGVRVMDA 290

  Fly   265 YETLFAYP----LPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGEDIV--DSGQNGLESLQETL 322
            .:.....|    :|       |||.|.|.:::. .....|:..|.|:::  :.|.....: |.|:
Mosquito   291 LDEHIGLPYRSYMP-------KVDQVALTQFSAGAMENWGLCKYREEVLLFEPGVTTYRA-QTTI 347

  Fly   323 AELVA----RQWNGLLVNLE------------------DSDEEYVRNGINYYLSVQVM--AMDKE 363
            ..::|    .||.|.::..|                  .:|..|.........:|||:  .:..:
Mosquito   348 TTIIAHEYVHQWFGNVITNEWWSYLWLNEGFATLYEFLGADMAYPERQYRDLFNVQVVQRVLITD 412

  Fly   364 AYNTTHLSKTRLDVLYHDSLAKVKSIATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQE 428
            |..:|..........::..|:...::|.....|            ::.|.::.|.|..:.:.|:.
Mosquito   413 AAESTRPMTFSRGATFNAILSLFDNVAYSKGGS------------VLQMFRLLLPDAAWRQMLRT 465

  Fly   429 FFK----RYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQI 489
            :.:    ...|:......|.|.|....    .||.|..:...:.||:.|.|:|:|.|:|....::
Mosquito   466 YVQGNEFGTVNTDNFVAALTEAFDGVV----SLPEGTDVERFVHSWVNQAGYPVLEVRRSYRGEM 526

  Fly   490 VTITQSRYYQKYLDNSSNDCWWVPVAYIVR---NLTLPQVEWLGCQKNSRDILELSHIANPEDWL 551
            : ::|.|:|...:.|:....|.:|...:.:   ...|.:.:|:    .|:.:...|...|.| |:
Mosquito   527 I-LSQDRFYGNKIVNNDFTVWVIPYTMMEQGDAQDALLEWQWM----TSKAVRVPSSTPNNE-WI 585

  Fly   552 LINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISY 616
            |:||:.....||.||..|..::...|.:|...||..||.||:||:..|:.|.||...:.|.::.|
Mosquito   586 LVNVNQTGFYRVNYDPSNWYMLIRTLLEDTAAIPMHSRAQLIDDSFHLARSNRLDLEIALELLGY 650

  Fly   617 LSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPIN 681
            :.:|.....||.|...|......||....:.:::|::..||...|.|.
Mosquito   651 VRHEREYPPWEAANRVLSYFHGRMRGQPDYILYELFVDTLIGDVFVTL----------------- 698

  Fly   682 TKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAIL 746
                                                         ..||.:||....:..|..::
Mosquito   699 ---------------------------------------------DITTVAPDERLLEKYLRQVI 718

  Fly   747 YRLACQFEIKECLT---DAQQR--FQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMF 806
            ...||:.||:.|:|   ||.:|  |.|       ..:..::..:|.|.|:|....|.:..:....
Mosquito   719 SSWACRMEIESCMTATRDALEREVFDA-------EPVHPDVSAVVYCYGLRTAPTVAFQYLFGKL 776

  Fly   807 FESENDKERSILLNSLSCTTEYWAMQKLLSWALDSK---KVPRTMTASLLSAVLRSPLGYYVGKQ 868
            ..|:|..||.:|:|:|.|..:...:...|..|:..:   ........|:|.:||.|..|.....:
Mosquito   777 LGSDNRGERQLLINALGCANDTEQLSSYLLAAIGGELQVNFNAEERLSILQSVLSSRQGVDALIE 841

  Fly   869 FLIDHSKEILR-------SKDVKLILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESG 926
            ||.::...::.       :..|:.|.|. .|.:..:....||.:.|:..||:::.:...:|....
Mosquito   842 FLTENYTYVVSLLGPNALANLVQSIATS-TNTLDEEQMLIALLEQLNSVLPANVSASARTTASIN 905

  Fly   927 LDRVNWRNNL---YF 938
            |...:.|..|   ||
Mosquito   906 LAWPSTREGLLLRYF 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	94/501 (19%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	86/392 (22%)
AgaP_AGAP013150	XP_003436699.1	Peptidase_M1	51..443	CDD:279741	80/419 (19%)
		M1_APN_2	59..514	CDD:189008	94/501 (19%)
		ERAP1_C	585..892	CDD:288671	83/376 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820