DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and AgaP_AGAP013255

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_003436572.1	Gene:	AgaP_AGAP013255 / 11175602	VectorBaseID:	AGAP013255	Length:	935	Species:	Anopheles gambiae

Alignment Length:	1014	Identity:	197/1014 - (19%)
Similarity:	364/1014 - (35%)	Gaps:	257/1014 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQ--FEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGR 84
            |.|..|::.|...|..|..:.|  |:|...|.: :||..     |.:.|.:...|..|..|:..|
Mosquito    51 VWPTHYDIEIKPYLEQEGNKAQFTFDGSAKITV-STQKQ-----NVMQIKLHMARMDITAWSVTR 109

  Fly    85 KIGALQIKRI----IKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYY-DKTPRV 144
            |.....|..:    .::|.::.:.:...|::...|.|:..:.||:| ...:|::..|| :...:|
Mosquito   110 KSDNTIIPTLPQTYDQETQILTLPLSSALQANVEYVLSFTYVGNMD-DDMHGFYRSYYWEDGVKV 173

  Fly   145 FYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMG 209
            :..:|:.:..:|...|||||:|||:..:.:.:.|..:|...|| ..:......|:...: |||..
Mosquito   174 WMGSTQFQQTHARRAFPCFDEPRFKATFQLKINHKTQYNVYSN-TAIVGTAVAEVGRSL-TTFGV 236

  Fly   210 SPPLATQQVMWTL--HQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYP 272
            :|.:::..:.:.:  :|:..        .:.:.:.:||....:.....::...|....:....||
Mosquito   237 TPSMSSYLIAFIVAPYQIND--------RDGMGILARPQAQNQTQYSLDVGIKLLKALDEWLDYP 293

  Fly   273 LPKGADWGGKVDHVVLPRYTEMY------------SGQGIMVYGE-DIVDSGQNGLESLQETLAE 324
                        :..:|..|.||            ...|::.|.| :|:....:.....|:.:|.
Mosquito   294 ------------YASMPAMTRMYMAAVPDFSAGAMENWGLLTYREANILYRSDDSTSMQQQRIAT 346

  Fly   325 L----VARQWNGLLVNLEDSDEEYVRNGI-NYYLSVQVMAMDKEAYNTTHLSKTRLD-------- 376
            :    :|.||.|.||..|..|..::..|. .||           .|..|.|.:|..|
Mosquito   347 VISHEIAHQWFGDLVTCEWWDVAWLNEGFARYY-----------EYYATALVETNWDFEDQFVVA 400

  Fly   377 ----VLYHDSLAK----VKSIATDVKESG-HQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKR 432
                |:..|||..    ...:.|..:.|. ...:...|..:::.|::..|..:.|...|:.:.|.
Mosquito   401 QLQSVMQMDSLRSTHPMTHPVYTQAESSAIFDSITYNKGAVVLRMMEHYLTTETFKTALRAYIKD 465

  Fly   433 YANSSASSKELWEEFQR---GARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQ 494
            .|..:...::|:....|   .||            :.||.|..|||:||:||...|..  .|:||
Mosquito   466 RAFKTTRPEDLFSALNRYDPNAR------------SYMEPWTVQPGYPLVTVTSHDTG--FTVTQ 516

  Fly   495 SRYYQKYLDNSSNDCWWVPVAYIVR----NLTLP--------QVEWLGCQKNSRDILELSHIANP 547
            .|:.....|::....|.:|:.:..:    ::|.|        ::...|              |:.
Mosquito   517 KRFLVNEPDHNEQTAWPLPITFATKASEFSITRPAFYTGMTFEIPMQG--------------ASD 567

  Fly   548 EDWLLINVDAAVPLRVFYDSYNLQLISEALRQD-FTQIPELSRIQLVDDALSLSWSGRLPYNVTL 611
            .::.::|.......||.||:.....||:||..: |..|..|:|.|:|||..:|:....:||...|
Mosquito   568 VEYFILNNQQVGYYRVNYDAILWGKISKALHSEGFGGIHVLNRAQIVDDLFNLARGDVVPYGTAL 632

  Fly   612 NVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIF----KLYMQKLIEPAFKTTLNSLSTKA 672
            .::.||..||....|..|:..|..|..        ||.    ||:...::: .|....:.:..:|
Mosquito   633 EILEYLKEETEYAPWLAAVNGLTTLSR--------RIHADDEKLFAAHILD-IFSKAYDIVKFQA 688

  Fly   673 RTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTK 737
            .|.:|..|.|
Mosquito   689 PTATERRIFT------------------------------------------------------- 698

  Fly   738 SDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMV 802
               .:...:.:.||.:..:||...|...|. ...|..|..:..::.::|.|.|||.|....:..:
Mosquito   699 ---YMRQNVLQWACNYGHEECSKAAVAEFH-RYHQNPSVKVHPDLGQVVYCEGIRKGSMEEFEFL 759

  Fly   803 RDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGK 867
            .:.:..:....|:.::|..|.|.:.    .:|::..||:...|...:....:|     ..|.:..
Mosquito   760 WNQYLTTNMATEQLLILQGLGCASS----SELITIMLDAITSPHVRSQDKSNA-----FTYVINN 815

  Fly   868 QFLIDHSKEI----------------------------LRSKDVKLILTPFINA----------- 893
            .:.:.|....                            |:|...:.:::.||.:
Mosquito   816 LYTLPHVSRYLQQNHAIWAASHGSYANVASAFNNVLARLKSDSERDVISAFIESNKNILGQAAYD 880

  Fly   894 --------MSTKAEFSALN-DHLHRNLPSSMVSGLSSTL 923
                    ..|..:|:..| |.:|..|.:.:..|.::.|
Mosquito   881 SIKTGLEDYETNKQFTLRNRDEIHEFLDNKINGGAATIL 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	103/498 (21%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	76/426 (18%)
AgaP_AGAP013255	XP_003436572.1	Peptidase_M1	46..439	CDD:279741	88/427 (21%)
		M1_APN_2	54..501	CDD:189008	103/498 (21%)
		ERAP1_C	571..888	CDD:288671	68/393 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920