DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and lvrn

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_031748993.1	Gene:	lvrn / 100496094	XenbaseID:	XB-GENE-980447	Length:	990	Species:	Xenopus tropicalis

Alignment Length:	996	Identity:	249/996 - (25%)
Similarity:	421/996 - (42%)	Gaps:	189/996 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PLRYNLTILTRLGSEDEQN-QFEGIVSIDIEATQPTRVIYLNSLNITIS-------RQRTWIYRW 80
            ||.|:|.:..|:..::|.| .|.|.|:|.|...:.|.|:.|:|:.:..|       ..:|.:|:
Frog    78 PLHYDLELWPRMEEDEEGNYPFSGQVNITISCVEDTDVVLLHSIQLNFSDVGLRLLGNKTIMYQ- 141

  Fly    81 ASGRKIG---ALQIKRIIKK------------TSLIK---------IVIELPLR--SGEIYTLNM 119
             |..|.|   |||..|..|:            .|:..         :|:||..|  :|.:|.|.:
Frog   142 -SMEKDGKHNALQEGRAYKRLQDPTYDIHGGNVSINNVWTFEDHSYVVLELNERLVAGNLYLLEL 205

  Fly   120 LFSGNLDRSQQYGYFAGYY-----DKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHD 179
            .::|.:  .|....|..:|     ||.    ..|:.|||:||..|:||||:|..:..:.|.|||:
Frog   206 NYTGFI--RQNTALFITHYKDFNIDKA----VVASLLEPEYARAVYPCFDEPALKATFKIRLVHN 264

  Fly   180 RKYVALSNMPPVEEKPYKEIEN--YVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVW 242
            ..||||||||.|.....::|:.  :..|||..:|.::|....:.:...:  |......|..|.||
Frog   265 SSYVALSNMPAVAVSEREDIDGSIWTVTTFDTTPKMSTYITAFVICDFD--YVNITERGNEIRVW 327

  Fly   243 SRPHLAEK--LAKVPEMTPNLFSKYETLF--AYPLPKGADWGGKVDHVVLPRY-TEMYSGQGIMV 302
            :|..:.:|  .:....:...|.|..|.||  :|||.       |.|.|.||.. .|.....|::.
Frog   328 ARKEVVQKGFASLALSIAGPLLSYMEDLFNVSYPLQ-------KTDFVALPDLDVEAMENWGLIT 385

  Fly   303 YGED--IVDSGQNGLESLQET---LAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDK 362
            :.|:  |.|..|....|...|   ::..:|.||.|.||.::...:.::..|...|:
Frog   386 FIEEALIYDPRQKSSNSKFRTSLIVSHEIAHQWFGNLVTMKWWTDLWLNEGFATYM--------- 441

  Fly   363 EAYNTTHL-SKTRLDVLY----------HDSLAKVKSIATDVKE-----SGH--QKLRKKKMCLL 409
            |.:..|.| ||..|:.|:          .|..|..|:::...:|     |.|  .:....|...|
Frog   442 EYFGITFLDSKLELNELFTMHNLQPIFERDVGAHAKTVSMKEEELYEADSSHMFNEFTYDKGSAL 506

  Fly   410 IHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQ----LPTGVSLPTVMESW 470
            :.||...|.:|||:||:..:.|.::.|:....:||...|...  .||    |||  :|..:|:||
Frog   507 VRMLSSFLTEKLFIKGISSYLKTFSFSNVDQDDLWNHLQMFI--DHQDEVRLPT--TLRHIMQSW 567

  Fly   471 MKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDN---SSNDCWWVPVAYIVRNLTLPQVEWLGCQ 532
            ..|.|.||||:.....:    :.:..:.....||   .||..|.|||.: ::|.|.....||..:
Frog   568 TWQRGIPLLTLDTTTGE----LAEELFKTDNTDNITSDSNHTWIVPVTW-MKNGTKQISLWLDSK 627

  Fly   533 KNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDAL 597
            .....:|..:    .::|:::|::.....|..|:..|...:::.|..:...:|.::||||::||.
Frog   628 SKVFPVLTTA----ADEWIVLNINVTGYYRTNYNKENWNRLAKQLEANPKVVPTVNRIQLIEDAF 688

  Fly   598 SLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFK 662
            .|:..|...:...|::..||..|..:.||.|.|.::......:...|.|.:||.|:.|.|.|.::
Frog   689 ILARYGYTDHGTALSLTKYLEKEEEINVWYTVLKHVTSSDYPLITYTNFPLFKKYILKRISPIYQ 753

  Fly   663 TTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESS 727
            ...||:                                                         ..
Frog   754 RFANSI---------------------------------------------------------RR 761

  Fly   728 DTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIR 792
            :..|:.|.....:.:..|| :.||.|.:::||..|.|.:...|...|.:.|||.||..:.|..|.
Frog   762 NFDEAADDYFIQVHIELIL-KTACSFGLQDCLQLAHQLYATWMKNCSGNVIPESIRNPICCYAIA 825

  Fly   793 NGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVL 857
            ||.|..|.....|..:|| :.||.:|..:||||.|.|.:.:.|.::|:..|   :...::...|:
Frog   826 NGGEKEWEFAWKMVNKSE-EIERDLLFYALSCTKEPWLLHRYLEYSLEMYK---SSAFTIFLDVI 886

  Fly   858 RSPLGYYVGKQFLIDHSK---EILRSKDV----KLILTPFINAMSTKAEFSALNDHLHRNLPSSM 915
            ::.:|.::..:||.::.:   :|...:|.    .::|..|.:..::..:|..:...::..:..:.
Frog   887 KNEIGRHIAWEFLKENWQRIHDIFGPRDTVDFYTVLLPTFASKAASDLQFQEIQLFINTTINENQ 951

  Fly   916 VSGLSSTLESGLDRVNWRNNL 936
            ...:...:|:     .||.:|
Frog   952 RERILEQVEN-----KWRKSL 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	146/524 (28%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	81/384 (21%)
lvrn	XP_031748993.1	M1_APN-Q_like	79..568	CDD:341064	143/518 (28%)
lvrn	XP_031748993.1	ERAP1_C	641..945	CDD:403137	81/365 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010