DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and enpep

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_002934295.1	Gene:	enpep / 100494326	XenbaseID:	XB-GENE-977050	Length:	965	Species:	Xenopus tropicalis

Alignment Length:	1007	Identity:	210/1007 - (20%)
Similarity:	391/1007 - (38%)	Gaps:	252/1007 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SFVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLN--------SLNITISRQRTW 76
            :::.|:.||:    .|....||:.:.|.|||.:..::.::.::|:        .|.:|...|:..
Frog   102 TYINPVHYNV----ELHPVMEQDTYNGTVSIWLRLSKTSKHLWLHLRETKIIGQLTLTRGSQQIP 162

  Fly    77 I---YRWASGRKIGALQIKRIIKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYY 138
            |   :::.....: .|:.::::...|        |....:.|.|.:.|:|.||     |...|:|
Frog   163 IQQCFQYIPNEYL-VLEAQQVLDPNS--------PTDENDTYCLTLQFAGRLD-----GSLVGFY 213

  Fly   139 DKTPRVFY---------SATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEK 194
                |..|         :|...||..|...|||||:|..:..|.|:::|..:|.|:||||..|..
Frog   214 ----RTTYQENGVTKSIAAADHEPTDARKSFPCFDEPNKKATYTISIIHREEYDAISNMPVQESV 274

  Fly   195 PYKEIENYVSTTFMGSPPLATQQVMWTLHQLE------------KVYSGPAAAGENITVWSRPHL 247
            ...  ..:..|.|..|.|::|..|.:.:||.:            ::|..|.   :|.|
Frog   275 ALG--NGWKRTLFEKSVPMSTYLVCFAVHQFKYVERLSKRGVPLRIYVQPL---QNAT------- 327

  Fly   248 AEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRY-TEMYSGQGIMVYGED--IVD 309
            ||..|...::..:.|.:|..: .|.||       |:|.:.:|.: |......|::.|.|.  :.|
Frog   328 AEYAANTTKIVFDFFEEYFNM-PYSLP-------KLDQIAIPDFGTGAMENWGLITYRETNLLYD 384

  Fly   310 SGQNGLESLQETLA----ELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTH- 369
            ..::...:.|...|    ||| .||.|.:|.::..|:.::..|...:.....:...:..:|...
Frog   385 PNESATVNKQRVAAVIAHELV-HQWFGNIVTMDWWDDLWLNEGFASFFEYSGVDAAEPLWNMLDQ 448

  Fly   370 -LSKTRLDVLYHDSLAKVKSIATDVK-----ESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQE 428
             |....|.|:..|:|.....|...|.     .|....:...|...::.||:..:..:.|.||.|:
Frog   449 ILIDDLLPVMRDDALLSSHPIIVTVSTPAEITSVFDAISYNKGASILRMLEDWISPENFKKGCQD 513

  Fly   429 FFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTIT 493
            :.|.|...:|.:.:.|....:.        :|..:..||::|.:|.|:|:|.|:     .:.|:.
Frog   514 YLKDYVFKNAKTDDFWNSLAKA--------SGKPVKEVMDTWTRQMGYPVLNVE-----SLNTVK 565

  Fly   494 QSRYYQKYLDNSSND---------CWWVPVAYIVRNLTLPQVEWLGCQKNSRDI----------- 538
            |:|:   .||.::|.         .|.:||.:...|             ||.|.
Frog   566 QTRF---LLDPNANALEPPSEFNYMWNIPVTFYATN-------------NSVDYNLLYNKSIPAG 614

  Fly   539 LELSHIANPED-WLLINVDAAVPLRVFYD--SYN-LQLISEALRQDFTQIPELSRIQLVDDALSL 599
            |.|:...:..| :|.||.......||.|:  ::| |..:.||..:.||   :..|..|:|||.:|
Frog   615 LSLTPFNDATDGFLKINTRHLGFFRVNYELSTWNQLSALLEANHETFT---DADRAGLIDDAFAL 676

  Fly   600 SWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMR-MTTGFRIFKLYMQKLIEPAFKT 663
            :.:.:|.||::|::..||..||:.|.|..|:.:|..|..::. ..|.:..|:.|::|.::|
Frog   677 ARAEKLDYNISLDITKYLEKETNYLTWTRAISSLAYLSDMLEDDNTIYPKFQEYLRKQVKP---- 737

  Fly   664 TLNSLSTK---ARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTE 725
                ::.|   ..|||:|
Frog   738 ----ITQKHGWEDTGSDI----------------------------------------------- 751

  Fly   726 SSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRG 790
                         |..|.|.:..|:|:....:.|.:|.:.|:   |.....|||..:|::|...|
Frog   752 -------------DKLLRASVLALSCKMGDPDALNEASRLFR---DWIGGKSIPVNLRQLVYRYG 800

  Fly   791 I-RNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLS 854
            : ::|.:..|..:...:..:...:|:..||..|:.......:.:.|....::..:......:::
Frog   801 MQQSGNQESWNYMFQQYLTTSLAQEKEKLLQGLASANNIELIDRYLKLIYNTSLIKSQDALNVI- 864

  Fly   855 AVLRSPLGYYV------GKQ-----------FLIDHSKEILRSKDVKLILTPFINAMSTKAEFSA 902
                    ||:      |||           :|:|...  :..:::..|:|......:|..:...
Frog   865 --------YYISVYSQYGKQMAWDWVRINWDYLVDRYN--INDRNLGRIVTRISGTFNTATQLWQ 919

  Fly   903 LNDHLHRNLPSSMVSGL--SSTLESGLDRVNW 932
            : ::.....|::....:  ...||:..:.:.|
Frog   920 M-ENFFEKYPNAGAGEIPRKQALETVRNNIEW 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	113/497 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	76/404 (19%)
enpep	XP_002934295.1	M1_APN-Q_like	107..549	CDD:341064	111/492 (23%)
enpep	XP_002934295.1	ERAP1_C	627..946	CDD:378732	76/404 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920