DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and anpep

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	901	Identity:	209/901 - (23%)
Similarity:	353/901 - (39%)	Gaps:	201/901 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SGNLDRSQQYGYF-----------AGYY------DKTPRVFYSATRLEPDYAHTVFPCFDDPRFR 169
            :.||...:|||.:           ||:|      |...::..:.....|| |...|||||:|..:
Frog   174 AANLVPGKQYGLYTEFVGELADDLAGFYRSEYLEDGVTKIIATTQMQAPD-ARKAFPCFDEPAMK 237

  Fly   170 TPYNITLVHDRKYVALSNMPPVEEKPYKEI-ENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPA 233
            ..:||||.:.:.|.|:|||..::.....|. :.:..:.|..:|.:::..|.:.:.:.|.|.....
Frog   238 ATFNITLKYRQPYKAMSNMREIDRSTVTEDGQQWTVSKFDKTPKMSSYLVAFIVSEFEAVGDPGN 302

  Fly   234 AAGENITVWSR------PHLAEKLAKVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYT 292
            |....:.:|.|      .:..|....|.:...:.|::|... .|||||.       |.|.||.::
Frog   303 ATVTGVQIWGRKKAIQDENQGEYALSVTKPILDFFAEYYRT-PYPLPKS-------DQVALPDFS 359

  Fly   293 E-MYSGQGIMVYGE------DIVDSGQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGIN 350
            . .....|::.|.|      |.|.|..| .|.:...:|..:|.||.|.||.:...::.::..|..
Frog   360 AGAMENWGLVTYRETALLFDDQVSSIGN-KERVVTVIAHELAHQWFGNLVTIRWWNDLWLNEGFA 423

  Fly   351 YYLSV----------------------QVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIATDV 393
            .|:..                      :|||:|  |..::|...:|.|.:  :|.:::.::...:
Frog   424 SYVEYLGADKAEPNWNIKDLIVLNDVHRVMAVD--ALASSHPLTSREDEV--NSPSEISALFDSI 484

  Fly   394 KESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLP 458
            ..|        |...:|.||...|.:.||:.||..:.|.:..|:....:||...|......
Frog   485 AYS--------KGASVIRMLSEFLTEPLFVDGLASYLKGFEYSNTVYSDLWTHLQWAVNNQ---- 537

  Fly   459 TGVSLP----TVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKY--LDNSS--------NDC 509
            |.|.||    .:|::|:.|.|||::.:  |.|..:||       ||:  ||..|        :..
Frog   538 TAVKLPLPIKDIMDTWVLQMGFPVVKI--DTATGVVT-------QKHFLLDPDSVVTRPSPFDYK 593

  Fly   510 WWVPVAYIVR----NLTLPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRVFYDSYNL 570
            |.||::|.:.    |:      ||  |..|..:.:.....|  ||||:|::.....||.||..|.
Frog   594 WKVPISYKISSKEDNI------WL--QNESETVEDFKITGN--DWLLVNLNVTGYYRVNYDDNNW 648

  Fly   571 QLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEK 635
            ..:...|:.....||.::|.|::|||.:|:.:.::.....|:...|:|.:...:.|:.||..|..
Frog   649 SRLLNQLQTSHQAIPVINRAQIIDDAFNLARAKQITTIQALDTTKYISADREYMPWQAALSGLSY 713

  Fly   636 LQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTT 700
            ...:...|..|...|.||:..:.|.|:      ..|..||:.    |..||:.
Frog   714 FTQMFDRTEVFGPMKKYMKMQVNPLFE------YFKQETGNW----TNRPVSL------------ 756

  Fly   701 ESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQR 765
                    .|.....||..:                             ||.::|::||..|.:.
Frog   757 --------TDQYCEINTLST-----------------------------ACSYDIEDCLKFASEL 784

  Fly   766 FQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSLSCTTEYWA 830
            |...|.....::|...:|..|.|..:..|.|..|..|.|.|..::..:|:..|..:|:|:.|.|.
Frog   785 FSQWMATPQQNNIHPNLRTNVYCTAVAQGGEQEWNFVWDRFQLTDIAQEQDKLRAALACSKEPWI 849

  Fly   831 MQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSKDVKL---------- 885
            :.:.|.::||...:.|....|.:|:|:.:|:|..:...|        :|:|...|
Frog   850 LNRFLEYSLDPTMIRRQDAVSTISSVVNNPIGQSLAWDF--------VRAKWKTLYSMFGESSFS 906

  Fly   886 ---ILTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESGLDR----VNWRN 934
               ::.......||:.|...|......|......:. |..||..:::    :||.|
Frog   907 FGNLIERVTRRFSTEFELQQLLQFKADNQNPGFGTA-SQALEQAIEKTKANINWVN 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	98/411 (24%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	85/390 (22%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	96/406 (24%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	86/394 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110