DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and trhde

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_002939988.3	Gene:	trhde / 100489066	XenbaseID:	XB-GENE-1013649	Length:	1020	Species:	Xenopus tropicalis

Alignment Length:	975	Identity:	243/975 - (24%)
Similarity:	429/975 - (44%)	Gaps:	159/975 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQFE--GIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGR 84
            ::||.|||.:...:      |.|.  |.|:::||....:|.|.:::..:|:.|.:.     |..|
Frog   140 LRPLHYNLMVTAFM------NNFTFCGEVNVEIECLNSSRYIVVHAHRLTVERVQV-----AEDR 193

  Fly    85 KIGALQIKRII--KKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYF-AGYYDKTPRVFY 146
            ..|.:::....  .:..::.:|:...|.:.:.|.|.:::|..:: ::..|:| :.|.....|...
Frog   194 VAGEVKVSHYFPYPQNQVLVVVLNRSLEAQKSYNLKIIYSAIIE-NELLGFFRSSYVLHGERRSL 257

  Fly   147 SATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMGSP 211
            :.|:..|.:|...|||||:|.::..:.|::.|...|::|||| |||...::| ..:|:..|..:|
Frog   258 AVTQFSPIHARKAFPCFDEPIYKATFKISIRHQTSYLSLSNM-PVETSVFEE-GGWVTDHFSQTP 320

  Fly   212 PLATQQVMWTLHQL---EKVYSGPAAAGENITVWSRPHLAEKLA--KVPEMTPNLFSKYETLF-- 269
            .::|..:.|.:...   |.|    ..:|..:.:::||....:.:  ....:|..|...||..|
Frog   321 LMSTYYLAWAVCNFTFKEAV----TQSGVVVRLYARPDAIRRGSGDYALNITKRLLEFYEDYFRV 381

  Fly   270 AYPLPKGADWGGKVDHVVLPR--YTEMYSGQGIMVYGED--IVDSGQNGLESLQE---TLAELVA 327
            .|.||       |:|.:.:|:  |..| ...|:.|:.|.  ::|...:.:..|.:   .:...:.
Frog   382 PYSLP-------KLDLLAVPKHPYAAM-ENWGLSVFVEQRILLDPSISSISYLLDVTMVIVHEIC 438

  Fly   328 RQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTHLSKTRL--DVLYH----DSLAKV 386
            .||.|.||.....::.:::.|:.:|.  :.:..| ..|...::.|.|.  |||:.    |.||..
Frog   439 HQWFGDLVTPIWWEDVWLKEGLAHYF--EFVGTD-YLYPGWNMEKQRFLTDVLHEVMLLDGLASS 500

  Fly   387 KSI------ATDVKESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKELWE 445
            ..:      |||: :.....:..||...||.||...:|.|:|.:|||::...:...:|:..:||.
Frog   501 HPVSQEVLKATDI-DRVFDWIAYKKGAALIRMLANFMGHKVFQRGLQDYLTTHKYGNAARNDLWN 564

  Fly   446 EFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDD-AKQIVTITQSRYYQKYLDNSSND- 508
            ...:..:...:|   :::..||:.|..|.|:|::|:.|:| ...|:||||..:... :|..:.|
Frog   565 TLTKVLKNEGKL---LNIREVMDQWTLQMGYPVITILRNDTTDDIITITQEHFLYN-IDKRTRDK 625

  Fly   509 -------CWWVPVAYIVRNLT--LPQ-VEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRV 563
                   .|.:|:...|.|.:  .|| :.|:..:.....|..|    :..:|:|.|:|.....||
Frog   626 EFRNKSSLWQIPLTIAVGNTSHISPQAIIWVSNKSEYHRIPSL----DESNWVLGNLDQIGYFRV 686

  Fly   564 FYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWET 628
            .||..|.:|:::.|.::...|...:|..|:|||.:|:.:|.|..|:.|.:|.|||.|...|.|..
Frog   687 NYDVRNWRLLTDQLMRNSEVISVSNRAALIDDAFNLARAGYLTQNIPLEIIRYLSEEKDFLPWHA 751

  Fly   629 ALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTKSPVTTESSGT 693
            |...|..|..::..|..:.||..|:.|.:...:...  ...|..:.||.:|
Frog   752 ASRALYPLDKLLDRTEDYSIFSEYILKQVSTMYFRL--GWPTNGQNGSAVP-------------- 800

  Fly   694 TESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKEC 758
                                :|..||                   :|....|:  |||.|..|:|
Frog   801 --------------------TSYQTE-------------------ELRREVIM--LACSFGNKQC 824

  Fly   759 LTDAQQRFQAAMDQKSSSS---IPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLN 820
                .|:....:....||:   ||..:|:||.|.|:....|..|..:...|..|....|:.|||.
Frog   825 ----HQKAATMISDWISSNRNRIPPNVRDIVYCTGVSLMDEDVWEFIWMKFHSSTAVSEKKILLE 885

  Fly   821 SLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSK---- 881
            :|:|:.....:.:||:.:|:|:.|.......::..|.|:|.|..:..:|..|..| ||.::
Frog   886 ALTCSDNRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWK-ILNARYGEA 949

  Fly   882 ---DVKLI--LTPFINAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRNNLYFDLL 941
               :.|||  :|.|:|   |:.|.:.|.|.:.::...|.|:.||...|:....|.|: :||.|.|
Frog   950 LFMNSKLISGVTEFLN---TEEELNELKDFIQQHKGGSAVASLSRATETVDANVRWQ-HLYRDEL 1010

Fly 942 941
Frog 1011 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	115/482 (24%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	100/389 (26%)
trhde	XP_002939988.3	M1_APN-Q_like	143..588	CDD:341064	113/477 (24%)
trhde	XP_002939988.3	ERAP1_C	673..998	CDD:403137	101/389 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020