DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6071 and lnpep

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_002933474.1	Gene:	lnpep / 100216271	XenbaseID:	XB-GENE-950921	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	993	Identity:	204/993 - (20%)
Similarity:	389/993 - (39%)	Gaps:	218/993 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTI---LTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASG 83
            :||:.|.||:   :|.:       .|.|.|.|.:..|..:..|.|:|..:.|.:....:..
Frog   171 IKPVHYVLTLHPDMTTM-------YFAGTVQIKLNITASSNNIVLHSSGLRIIKAHVSVTE---- 224

  Fly    84 RKIGALQIKRIIKKTSLIKIVIELP--LRSGEIYTLNMLFSGNLDRSQQYGYF-AGYYDKTPRVF 145
               |......:::..:..:|.|.||  |..|:...|.:.::.|.. |..||:: ..|.:|..:..
Frog   225 ---GTTMDAEVLEYPTFEEIAIILPESLPKGKECLLTIQYTSNFS-STYYGFYKIDYMEKGNKRS 285

  Fly   146 YSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKE------------ 198
            .:||:.||..|..||||||:|.|::.:.|.::.::..::|||||..:.....:
Frog   286 LAATQFEPLAARKVFPCFDEPAFKSTFQINIIRNQSMISLSNMPKAKTSTMSDGLLLDEYSTSVN 350

  Fly   199 IENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFS 263
            :..|:....:|.....||:...||                ::|::.|...:::....:....|..
Frog   351 MSTYLVAFIVGDIKNTTQETNDTL----------------VSVYAVPEKMDQVKYALDSAMKLLY 399

  Fly   264 KYETLF--AYPLPKGADWGGKVDHVVLPRYTEMYSG-----------QGIMVYGEDIVDSGQNGL 315
            .|...:  ||||.       |:|.|.:|   :..:|           :..::|.||  .|.....
Frog   400 FYSNYYNIAYPLK-------KLDLVAIP---DFQAGAMENWGLITFRETALLYKED--SSSVADK 452

  Fly   316 ESLQETLAELVARQWNGLLVNLEDSDEEYVRNGINYYLS-VQVMAMDKEAYNTTHLSKTRLDVLY 379
            :|:.:.:|..:|.||.|.||.:|..::.::..|...|:. |.:.::..|..:.....|.|...|.
Frog   453 QSITKVIAHELAHQWFGNLVTMEWWNDLWLNEGFATYMEYVSMSSLFPELNSENSFLKMRFTALQ 517

  Fly   380 HDSLAKVKSIATDVK-----ESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSAS 439
            .|||.....|:||::     |.....|...|...::.||:..|.:.:|...:.|:.:.:...|.:
Frog   518 KDSLNASHPISTDIQSPEQIEEMFDDLSYIKGASILLMLQAFLSEDVFHHCIMEYLQAHQYGSTT 582

  Fly   440 SKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQ----K 500
            |..||:.......::      .::..:|::|.::.|:||:|..|...:  :|:.|.|:.:    .
Frog   583 SDSLWDSMNVVTNKN------PNVKNMMKTWTQKAGYPLVTALRKGEE--ITVQQERFLRTPSPD 639

  Fly   501 YLDNSSNDCWWVPVAYIVRNLT--LPQVEWLGCQKNSRDILELSHIANPEDWLLINVDAAVPLRV 563
            :..|:|. .|.:|:.|:.|..:  .||.:.:...|   ::....::::...|:..||:......|
Frog   640 HATNAST-VWHIPLTYVTRKCSGIEPQCDNIYLLK---EVTGRINVSSEFPWVKFNVNMTGYYIV 700

  Fly   564 FYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETSVLVWET 628
            .|.:.....:.:.|.:|.|.:....|..|:.|...|:..|::|......::.||:|||:......
Frog   701 DYGADGWDALIKQLLRDHTVLHSSDRANLIHDIFMLAGVGKVPLAKAFELLGYLANETNSAPITQ 765

  Fly   629 ALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKA-RTGSEIPINTKSPVTTESSG 692
            ||.....:..|:                    .|..|:.||.|. ..|.::..|..:. |.|..|
Frog   766 ALNQFYHIHGIL--------------------LKRGLDELSDKVMERGLKLLSNLINQ-TWEDEG 809

  Fly   693 TTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYRLACQFEIKE 757
            |.                                           ::..|.:.|...||...::.
Frog   810 TL-------------------------------------------AERELRSSLLDFACSSGLQS 831

  Fly   758 CLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDKERSILLNSL 822
            |:..|.:.|.  :.:.:::.||.::.::|...|.:..  ..|..:.|.:..|..:.|:..:|.:|
Frog   832 CVDKAMELFN--IWRLNNTRIPTDVMKVVFKVGAKTA--EGWAFLWDKYTTSLYETEKRKILEAL 892

  Fly   823 SCTTE----YWAMQKLLSWAL-DSKKVPRTMTASLLSAVLRSPLGYYVGKQFLIDHSKEILRSKD 882
            :.|..    .|.||:.|...| .|:::|     ::|..:.:...||.:..:|         ..::
Frog   893 ASTDNGRKLQWLMQESLDGGLIRSQELP-----AVLGFISKGSPGYLLAWEF---------AKQN 943

  Fly   883 VKLILTPFI-------NAMSTKAEFSALNDHLHRNLPSSMVSGLSSTLESGLDRVNW-------- 932
            ..||...|:       :.:||.....:.:.||     :.:::..:||  .|..|..|
Frog   944 WDLITQKFMPGSFPIQSIVSTTTYHFSTDTHL-----NEVIAFFNST--KGKSREMWCVKEAVET 1001

  Fly   933 --------RNNLYFDLLK 942
                    :|||  |.||
Frog  1002 IKFNIEWMKNNL--DSLK 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	106/488 (22%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	71/390 (18%)
lnpep	XP_002933474.1	M1_APN-Q_like	174..609	CDD:341064	105/483 (22%)
lnpep	XP_002933474.1	ERAP1_C	687..1003	CDD:378732	74/404 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020