DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and cfap91

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001120893.1	Gene:	cfap91 / 100151718	XenbaseID:	XB-GENE-995086	Length:	1038	Species:	Xenopus tropicalis

Alignment Length:	793	Identity:	149/793 - (18%)
Similarity:	273/793 - (34%)	Gaps:	230/793 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ESFVKPLRYNLTILTRLGSEDEQNQFE-GIVSIDIEATQPTRVIYLNSL---------NITISRQ 73
            |:.:.||.....:..|....|||.:.| .....:||..|..|:..|..|         .|...|.
Frog   229 EATLPPLSDTSQLEKRRKMMDEQERKEWAFREKEIEKLQEARLEVLQKLLQKREEKQKEIDTKRL 293

  Fly    74 RTWIYRWASGRKIGALQIKRIIKK--TSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAG 136
            .:   ||:..:.....:||:|.|:  |::.|:       :|::..:    .|.|:|......|:.
Frog   294 DS---RWSKLQAEKEERIKQIRKQHITAIRKL-------TGKMNNV----EGKLERRDIIKEFSD 344

  Fly   137 YYDKT----PRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVAL----SNMPPVEE 193
            ...:|    .|:.|...||...|.           .::|:.      ..|..|    :|:|....
Frog   345 CASQTYAPLSRIGYFPDRLSEQYV-----------VKSPFL------NSYQGLLELEANLPDFVT 392

  Fly   194 KPYKEIENYVSTTFMGSPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRP-HLAEKLAKVPEM 257
            :|..::....:||..|.  |....|:  ..:||:|::...|.........:| ...||:.| |..
Frog   393 QPRVKVPKVRTTTRSGF--LKRTAVL--DRELEQVHAALLANKTKTPTSKKPLRFLEKIEK-PAP 452

  Fly   258 TPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYTEMYSGQGIMVYGEDIVDSGQNGLESLQETL 322
            .|      ||......|:| |...::..::|.|   :..|:||           ||.:...:|..
Frog   453 RP------ETPRVQDPPEG-DEERELAVILLQR---LIRGRGI-----------QNTMFEGKEKC 496

  Fly   323 AELV-------ARQWNGLLVNLEDSDEEYVRNGINYYLSVQ---VMAMDKEAYNTTHLSKTRLDV 377
            .||:       |.|..|.|  |:.::::..       |::|   .:...|.:...:|||:....|
Frog   497 VELIQELRTTHALQEEGQL--LKKAEKQAT-------LALQRQRELGEHKASVLDSHLSELEGGV 552

  Fly   378 L--YHDSLAK----------VKSIA---------TDVKESGHQKLRKKK-------MCLLIHMLK 414
            |  ..|.|:|          :.:.|         .:.:|||.::|.:::       ...|:|:.:
Frog   553 LSDMFDFLSKELVRLQEERRIHAFAMLAERQRRIREAEESGLRQLEERRRREEDEIFRQLVHVQQ 617

  Fly   415 VALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFPLL 479
            ..:...|      |.....|..:.:.::..:|.||.|...:      .:...|||
Frog   618 STVDSYL------EEIILSATETTAEEQARQEIQRKAEEIN------DIAYQMES---------- 660

  Fly   480 TVQRDDAKQIVTITQSRYYQKYLDNSSNDCWWVPVAYIVRNLTLPQVEWLG----CQKNSRDILE 540
                         ::||...:.:           ||.:|.:..:|:|:...    .:::.|..::
Frog   661 -------------SRSRIQSEEI-----------VAELVYSFLIPEVQKTSVRDRVRRSQRRHIQ 701

  Fly   541 LSH-IANPEDWLLINVDAAVPLRVFYDSYNLQLISEALRQD----FTQIP--ELSRIQLVDDALS 598
            .:| :...:...|:..:.|  |:..:...|...:|:|..||    .|.:|  ::...:.......
Frog   702 AAHRVICQDTQALLEQNGA--LQSTFGGNNSASVSKATLQDPRGTETGVPAQDIRGTERDTQPQD 764

  Fly   599 LSWSGRLPYNVTLNVISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKT 663
            ..|. ..||:..:     |::|...:..:|
Frog   765 TRWI-ETPYSGNI-----LASEREAMPQDT----------------------------------- 788

  Fly   664 TLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSD 728
              :...|:|...:.....|::|...:....||:|....|....|:|....|...||:|.......
Frog   789 --HGTETEALAQNLCGTETETPAPDQCGTETEAPAQDLSGTEREAPAQDLSGTETEAPAPDLCGT 851

  Fly   729 TTESPDTTKSDLS 741
            .||:|   ..|||
Frog   852 ETEAP---AQDLS 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	102/510 (20%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	36/197 (18%)
cfap91	NP_001120893.1	PaaSYMP	169..321	CDD:291408	23/94 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910