DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6083 and GRE3

DIOPT Version :9

Sequence 1:	NP_648485.1	Gene:	CG6083 / 39305	FlyBaseID:	FBgn0036183	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_011972.1	Gene:	GRE3 / 856504	SGDID:	S000001146	Length:	327	Species:	Saccharomyces cerevisiae

Alignment Length:	313	Identity:	118/313 - (37%)
Similarity:	179/313 - (57%)	Gaps:	27/313 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSNGKNMPMLGLGTWRSPPEVVTQAVKDAIDIGYRHFDCAHIYGNEAQVGAALREKMDEGVVTRD 72
            |:||..||::|||.|:...:|....:.:||.:|||.||.|..||||.:||..:|:.:.||:|:|.
Yeast     7 LNNGLKMPLVGLGCWKIDKKVCANQIYEAIKLGYRLFDGACDYGNEKEVGEGIRKAISEGLVSRK 71

  Fly    73 ELFITSKLWNTHHKPDLVRPACETSIRNLGVKYLNLYLMHWPMAYK------SGSDNLYPTCPDT 131
            ::|:.|||||..|.||.|:.|.:.::.::|:.||:||.:|:|:|:|      ......|....|.
Yeast    72 DIFVVSKLWNNFHHPDHVKLALKKTLSDMGLDYLDLYYIHFPIAFKYVPFEEKYPPGFYTGADDE 136

  Fly   132 NKAAFED--IDYVDTWRAMENLVDEGLCQAIGVSNFNEQQMNRLLSVAKLKPVVLQIECHPYLSQ 194
            .|....:  :..:||:||:|..|||||.::||||||....:..||...::|||.||||.||||:|
Yeast   137 KKGHITEAHVPIIDTYRALEECVDEGLIKSIGVSNFQGSLIQDLLRGCRIKPVALQIEHHPYLTQ 201

  Fly   195 KPLITLCYDNAIAVTAYSCLG-----------SGHTPYEKPGAYPLLQHPTILAIAEKYE-RTAA 247
            :.|:..|..:.|.|.|||..|           :..||       .|.::..|..:::.:. .|.:
Yeast   202 EHLVEFCKLHDIQVVAYSSFGPQSFIEMDLQLAKTTP-------TLFENDVIKKVSQNHPGSTTS 259

  Fly   248 QVLLRFQTQSGIIVIPRSVSKQHMLDNFKRIWDFELAVDDIQAINELDCNGRF 300
            |||||:.||.||.|||:|..|:.:|.|.:....|.|...:::.|:.|:.|.||
Yeast   260 QVLLRWATQRGIAVIPKSSKKERLLGNLEIEKKFTLTEQELKDISALNANIRF 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6083	NP_648485.1	ARA1	1..300	CDD:223729	116/311 (37%)
CG6083	NP_648485.1	Tas	17..293	CDD:223739	109/295 (37%)
GRE3	NP_011972.1	AKR_SF	3..318	CDD:412396	118/313 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	211	1.000	Inparanoid score	I806
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		otm46528
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X51
TreeFam	1	0.960	-	-
	9	8.730