Protein Alignment Akr1B and AKR1C3

DIOPT Version :10

• Sequence 1: NP_729726.1
• Gene: Akr1B / 39304
• FlyBaseID: FBgn0086254
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_003730.4
• Gene: AKR1C3 / 8644
• HGNCID: 386
• Length: 323
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 156/314 - (49%)
• Similarity: 215/314 - (68%)
• Gaps: 9/314 - (2%)

  Fly    44 DGNEIPVIGLGTF---NSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKR 105
            ||:.:||:|.||:   ..|:.:..|..|:||:||:||||.|::|.||::||..:.:||.:|.|||
Human    12 DGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKR 76

  Fly   106 EDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSP 170
            ||:|.|||||:|||||:||:.||||:|...:|.|:||||||.||..|.|.:|.|||::||.::..
Human    77 EDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDI 141

  Fly   171 VDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATI--PPVTNQIECHPYLTQKKLIDFC 233
            ||...||:||||..:.||.||||||||||||:|.:|....:  .||.||:|||||..:.||:|||
Human   142 VDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFC 206

  Fly   234 KSKDITITAYSPLGSP-NRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKS 297
            |||||.:.|||.|||. ::.|.....||:||:..:..:|.|.|:||..|.:|||:||..:|:.||
Human   207 KSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKS 271

  Fly   298 VTKDRIESNFQVFDFELTPEEIEIIESFECNGRLVPLLKDA-GTHKYYPFHDEY 350
            ..:.||..|.|||:|:||.|:::.|:..:.|  |.....|: .:|..||:.|||
Human   272 YNEQRIRQNVQVFEFQLTAEDMKAIDGLDRN--LHYFNSDSFASHPNYPYSDEY 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_729726.1	AKR_SF	45..350	CDD:444925	153/311 (49%)
AKR1C3	NP_003730.4	AKR_AKR1C1-35	6..306	CDD:381334	149/295 (51%)