Protein Alignment Akr1B and AKR1C3

DIOPT Version :9

• Sequence 1: NP_001261716.1
• Gene: Akr1B / 39304
• FlyBaseID: FBgn0086254
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_001240837.1
• Gene: AKR1C3 / 8644
• HGNCID: 386
• Length: 323
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 156/318 - (49%)
• Similarity: 216/318 - (67%)
• Gaps: 10/318 - (3%)

  Fly    42 CL---DGNEIPVIGLGTF---NSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKE 100
            ||   ||:.:||:|.||:   ..|:.:..|..|:||:||:||||.|::|.||::||..:.:||.:
Human     7 CLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIAD 71

  Fly   101 GVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGK 165
            |.|||||:|.|||||:|||||:||:.||||:|...:|.|:||||||.||..|.|.:|.|||::||
Human    72 GSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGK 136

  Fly   166 TLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATI--PPVTNQIECHPYLTQKK 228
            .::..||...||:||||..:.||.||||||||||||:|.:|....:  .||.||:|||||..:.|
Human   137 VIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSK 201

  Fly   229 LIDFCKSKDITITAYSPLGSP-NRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANI 292
            |:||||||||.:.|||.|||. ::.|.....||:||:..:..:|.|.|:||..|.:|||:||..:
Human   202 LLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVV 266

  Fly   293 VIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLVPLLNQYGHPHHPFEKDEY 350
            |:.||..:.||..|.|||:|:||.|:::.|:..:.|.......:...||::|: .|||
Human   267 VLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPY-SDEY 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	146/282 (52%)
		Tas	45..>248	CDD:223739	114/207 (55%)
AKR1C3	NP_001240837.1	ARA1	9..305	CDD:223729	148/295 (50%)
		Tas	17..297	CDD:223739	144/279 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	1	1.100	-	-	O	PTHR11732
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830